Ohtsuki S, Terasaki T: Contribution of carrier-mediated transport systems to the blood-brain barrier as a supporting and protecting interface for the brain; importance for CNS drug discovery and development. Pharm Res. 2007, 24: 1745-1758. 10.1007/s11095-007-9374-5.
Article
CAS
PubMed
Google Scholar
Leggas M, Adachi M, Scheffer GL, Sun D, Wielinga P, Du G, Mercer KE, Zhuang Y, Panetta JC, Johnston B, et al: Mrp4 confers resistance to topotecan and protects the brain from chemotherapy. Mol Cell Biol. 2004, 24: 7612-7621. 10.1128/MCB.24.17.7612-7621.2004.
Article
PubMed Central
CAS
PubMed
Google Scholar
Mori S, Takanaga H, Ohtsuki S, Deguchi T, Kang YS, Hosoya K, Terasaki T: Rat organic anion transporter 3 (rOAT3) is responsible for brain-to-blood efflux of homovanillic acid at the abluminal membrane of brain capillary endothelial cells. J Cereb Blood Flow Metab. 2003, 23: 432-440.
Article
CAS
PubMed
Google Scholar
Ose A, Kusuhara H, Endo C, Tohyama K, Miyajima M, Kitamura S, Sugiyama Y: Functional characterization of mouse organic anion transporting peptide 1a4 in the uptake and efflux of drugs across the blood-brain barrier. Drug Metab Dispos. 2010, 38: 168-176. 10.1124/dmd.109.029454.
Article
CAS
PubMed
Google Scholar
Ohtsuki S, Ito S, Matsuda A, Hori S, Abe T, Terasaki T: Brain-to-blood elimination of 24S-hydroxycholesterol from rat brain is mediated by organic anion transporting polypeptide 2 (oatp2) at the blood-brain barrier. J Neurochem. 2007, 103: 1430-1438. 10.1111/j.1471-4159.2007.04901.x.
Article
CAS
PubMed
Google Scholar
Akanuma S, Hosoya K, Ito S, Tachikawa M, Terasaki T, Ohtsuki S: Involvement of multidrug resistance-associated protein 4 in efflux transport of prostaglandin E2 across mouse blood-brain barrier and its inhibition by intravenous administration of cephalosporins. J Pharmacol Exp Ther. 2010, 333: 912-919. 10.1124/jpet.109.165332.
Article
CAS
PubMed
Google Scholar
Alix E, Schmitt C, Strazielle N, Ghersi-Egea JF: Prostaglandin E2 metabolism in rat brain: Role of the blood-brain interfaces. Cerebrospinal Fluid Res. 2008, 5: 5-10.1186/1743-8454-5-5.
Article
PubMed Central
PubMed
Google Scholar
Sugimoto Y, Narumiya S: Prostaglandin E receptors. J Biol Chem. 2007, 282: 11613-11617.
Article
CAS
PubMed
Google Scholar
Chen C, Bazan NG: Endogenous PGE2 regulates membrane excitability and synaptic transmission in hippocampal CA1 pyramidal neurons. J Neurophysiol. 2005, 93: 929-941.
Article
CAS
PubMed
Google Scholar
Kurokawa M, Imakita M, Kumeda CA, Shiraki K: Cascade of fever production in mice infected with influenza virus. J Med Virol. 1996, 50: 152-158. 10.1002/(SICI)1096-9071(199610)50:2<152::AID-JMV8>3.0.CO;2-9.
Article
CAS
PubMed
Google Scholar
Nguyen MD, Julien JP, Rivest S: Innate immunity: the missing link in neuroprotection and neurodegeneration?. Nat Rev Neurosci. 2002, 3: 216-227. 10.1038/nrn752.
Article
CAS
PubMed
Google Scholar
Erickson MA, Banks WA: Cytokine and chemokine responses in serum and brain after single and repeated injections of lipopolysaccharide: Multiplex quantification with path analysis. Brain Behav Immun in press.
Oshima S, Nemoto E, Kuramochi M, Saitoh Y, Kobayashi D: Penetration of oseltamivir and its active metabolite into the brain after lipopolysaccharide-induced inflammation in mice. J Pharm Pharmacol. 2009, 61: 1397-1400.
Article
CAS
PubMed
Google Scholar
Golovko MY, Murphy EJ: An improved LC-MS/MS procedure for brain prostanoid analysis using brain fixation with head-focused microwave irradiation and liquid-liquid extraction. J Lipid Res. 2008, 49: 893-902. 10.1194/jlr.D700030-JLR200.
Article
CAS
PubMed
Google Scholar
Sapirstein A, Saito H, Texel SJ, Samad TA, O'Leary E, Bonventre JV: Cytosolic phospholipase A2α regulates induction of brain cyclooxygenase-2 in a mouse model of inflammation. Am J Physiol Regul Integr Comp Physiol. 2005, 288: R1774-1782. 10.1152/ajpregu.00815.2004.
Article
CAS
PubMed
Google Scholar
Yamagata K, Matsumura K, Inoue W, Shiraki T, Suzuki K, Yasuda S, Sugiura H, Cao C, Watanabe Y, Kobayashi S: Coexpression of microsomal-type prostaglandin E synthase with cyclooxygenase-2 in brain endothelial cells of rats during endotoxin-induced fever. J Neurosci. 2001, 21: 2669-2677.
CAS
PubMed
Google Scholar
Bastos GN, Moriya T, Inui F, Katura T, Nakahata N: Involvement of cyclooxygenase-2 in lipopolysaccharide-induced impairment of the newborn cell survival in the adult mouse dentate gyrus. Neuroscience. 2008, 155: 454-462. 10.1016/j.neuroscience.2008.06.020.
Article
CAS
PubMed
Google Scholar
Inoue W, Somay G, Poole S, Luheshi GN: Immune-to-brain signaling and central prostaglandin E2 synthesis in fasted rats with altered lipopolysaccharide-induced fever. Am J Physiol Regul Integr Comp Physiol. 2008, 295: R133-143. 10.1152/ajpregu.90335.2008.
Article
PubMed Central
CAS
PubMed
Google Scholar
Kim SY, Chang YJ, Cho HM, Hwang YW, Moon YS: Non-steroidal anti-inflammatory drugs for the common cold. Cochrane Database Syst Rev. 2009, CD006362-
Google Scholar
Hulscher ME, Grol RP, van der Meer JW: Antibiotic prescribing in hospitals: a social and behavioural scientific approach. Lancet Infect Dis. 2010, 10: 167-175. 10.1016/S1473-3099(10)70027-X.
Article
PubMed
Google Scholar
Nilwarangkoon S, Anzai N, Shiraya K, Yu E, Islam R, Cha SH, Onozato ML, Miura D, Jutabha P, Tojo A, et al: Role of mouse organic anion transporter 3 (mOat3) as a basolateral prostaglandin E2 transport pathway. J Pharmacol Sci. 2007, 103: 48-55. 10.1254/jphs.FP0060816.
Article
CAS
PubMed
Google Scholar
Taogoshi T, Nomura A, Murakami T, Nagai J, Takano M: Transport of prostaglandin E1 across the blood-brain barrier in rats. J Pharm Pharmacol. 2005, 57: 61-66.
Article
CAS
PubMed
Google Scholar
Jones RN: Cefmetazole (CS-1170), a "new" cephamycin with a decade of clinical experience. Diagn Microbiol Infect Dis. 1989, 12: 367-379. 10.1016/0732-8893(89)90106-5.
Article
CAS
PubMed
Google Scholar
Yamaoka K, Tanigawara Y, Nakagawa T, Uno T: A pharmacokinetic analysis program (MULTI) for microcomputer. J Pharmacobiodyn. 1981, 4: 879-885.
Article
CAS
PubMed
Google Scholar
Uchida Y, Ohtsuki S, Katsukura Y, Ikeda C, Suzuki T, Kamiie J, Terasaki T: Quantitative targeted absolute proteomics of human blood-brain barrier transporters and receptors. J Neurochem. 2011, 117: 333-345. 10.1111/j.1471-4159.2011.07208.x.
Article
CAS
PubMed
Google Scholar
Kamiie J, Ohtsuki S, Iwase R, Ohmine K, Katsukura Y, Yanai K, Sekine Y, Uchida Y, Ito S, Terasaki T: Quantitative atlas of membrane transporter proteins: development and application of a highly sensitive simultaneous LC/MS/MS method combined with novel in-silico peptide selection criteria. Pharm Res. 2008, 25: 1469-1483. 10.1007/s11095-008-9532-4.
Article
CAS
PubMed
Google Scholar
Warren HS: Editorial: Mouse models to study sepsis syndrome in humans. J Leukoc Biol. 2009, 86: 199-201. 10.1189/jlb.0309210.
Article
CAS
PubMed
Google Scholar
McCuskey RS, McCuskey PA, Urbaschek R, Urbaschek B: Species differences in Kupffer cells and endotoxin sensitivity. Infection & Immunity. 1984, 45: 278-280.
CAS
Google Scholar
Inoue W, Matsumura K, Yamagata K, Takemiya T, Shiraki T, Kobayashi S: Brain-specific endothelial induction of prostaglandin E2 synthesis enzymes and its temporal relation to fever. Neurosci Res. 2002, 44: 51-61. 10.1016/S0168-0102(02)00083-4.
Article
CAS
PubMed
Google Scholar
Salkeni MA, Lynch JL, Otamis-Price T, Banks WA: Lipopolysaccharide impairs blood-brain barrier P-glycoprotein function in mice through prostaglandin- and nitric oxide-independent pathways. J Neuroimmune Pharmacol. 2009, 4: 276-282. 10.1007/s11481-008-9138-y.
Article
PubMed Central
PubMed
Google Scholar
Chung DW, Yoo KY, Hwang IK, Kim DW, Chung JY, Lee CH, Choi JH, Choi SY, Youn HY, Lee IS, Won MH: Systemic administration of lipopolysaccharide induces cyclooxygenase-2 immunoreactivity in endothelium and increases microglia in the mouse hippocampus. Cell Mol Neurobiol. 2010, 30: 531-541. 10.1007/s10571-009-9477-0.
Article
CAS
PubMed
Google Scholar
Pan W, Hsuchou H, Yu C, Kastin AJ: Permeation of blood-borne IL15 across the blood-brain barrier and the effect of LPS. J Neurochem. 2008, 106: 313-319. 10.1111/j.1471-4159.2008.05390.x.
Article
PubMed Central
CAS
PubMed
Google Scholar
van Montfoort JE, Schmid TE, Adler ID, Meier PJ, Hagenbuch B: Functional characterization of the mouse organic-anion-transporting polypeptide 2. Biochim Biophys Acta. 2002, 1564: 183-188. 10.1016/S0005-2736(02)00445-5.
Article
CAS
PubMed
Google Scholar
Ohtsuki S, Kikkawa T, Mori S, Hori S, Takanaga H, Otagiri M, Terasaki T: Mouse reduced in osteosclerosis transporter functions as an organic anion transporter 3 and is localized at abluminal membrane of blood-brain barrier. J Pharmacol Exp Ther. 2004, 309: 1273-1281. 10.1124/jpet.103.063370.
Article
CAS
PubMed
Google Scholar
Kis B, Isse T, Snipes JA, Chen L, Yamashita H, Ueta Y, Busija DW: Effects of LPS stimulation on the expression of prostaglandin carriers in the cells of the blood-brain and blood-cerebrospinal fluid barriers. J Appl Physiol. 2006, 100: 1392-1399.
Article
CAS
PubMed
Google Scholar
Fattori S, Becherini F, Cianfriglia M, Parenti G, Romanini A, Castagna M: Human brain tumors: multidrug-resistance P-glycoprotein expression in tumor cells and intratumoral capillary endothelial cells. Virchows Archiv. 2007, 451: 81-87. 10.1007/s00428-007-0401-z.
Article
CAS
PubMed
Google Scholar
Hartz AM, Bauer B, Fricker G, Miller DS: Rapid modulation of P-glycoprotein-mediated transport at the blood-brain barrier by tumor necrosis factor-α and lipopolysaccharide. Mol Pharmacol. 2006, 69: 462-470.
Article
CAS
PubMed
Google Scholar
Bauer B, Hartz AM, Miller DS: Tumor necrosis factor α and endothelin-1 increase P-glycoprotein expression and transport activity at the blood-brain barrier. Mol Pharmacol. 2007, 71: 667-675.
Article
CAS
PubMed
Google Scholar
Van Dam AM, Brouns M, Man AHW, Berkenbosch F: Immunocytochemical detection of prostaglandin E2 in microvasculature and in neurons of rat brain after administration of bacterial endotoxin. Brain Res. 1993, 613: 331-336. 10.1016/0006-8993(93)90922-A.
Article
CAS
PubMed
Google Scholar
Komiya M, Kikuchi Y, Tachibana A, Yano K: Pharmacokinetics of new broad-spectrum cephamycin, YM09330, parenterally administered to various experimental animals. Antimicrob Agents Chemother. 1981, 20: 176-183.
Article
PubMed Central
CAS
PubMed
Google Scholar
Lin JH: Species similarities and differences in pharmacokinetics. Drug Metab Dispos. 1995, 23: 1008-1021.
CAS
PubMed
Google Scholar
Ko H, Cathcart KS, Griffith DL, Peters GR, Adams WJ: Pharmacokinetics of intravenously administered cefmetazole and cefoxitin and effects of probenecid on cefmetazole elimination. Antimicrob Agents Chemother. 1989, 33: 356-361.
Article
PubMed Central
CAS
PubMed
Google Scholar
Ci L, Kusuhara H, Adachi M, Schuetz JD, Takeuchi K, Sugiyama Y: Involvement of MRP4 (ABCC4) in the luminal efflux of ceftizoxime and cefazolin in the kidney. Mol Pharmacol. 2007, 71: 1591-1597. 10.1124/mol.106.031823.
Article
CAS
PubMed
Google Scholar