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Aims and scope

Fluids and Barriers of the CNS is an open access, peer-reviewed journal that considers manuscripts on all CNS fluids and barrier systems in health and disease.

Homeostatic maintenance of the internal environment of the nervous system through normal functioning of brain fluids and barriers is vital for health of the organism. The cerebrospinal fluid (CSF), its composition, circulation and absorption, has multiple roles in both normal and abnormal brain function and is closely associated with the parenchymal interstitial fluid and the neurovascular unit at the blood-brain barrier. The CNS fluids and barrier systems including the blood-CSF barrier, the blood-brain barrier, the blood-retinal barrier and the blood-nerve barriers, perform functions such as fluid secretion, chemical signalling, physical and chemical buffering, specialised directional transport and facilitation of immune surveillance.

The fluids and barrier systems are important in neurodevelopment and neurodevelopmental disorders such as congenital and perinatal hydrocephalus and neural tube defects, in aging and aging disorders such dementia, Alzheimer's, Parkinson's and normal pressure hydrocephalus. Throughout life they have an important role in brain inflammation, brain injury and repair, and neurodegenerative diseases such as multiple sclerosis. The CSF can be used for the diagnosis of neurological diseases, and together with the blood-brain barrier, as a route for drug delivery to the brain.

Fluids and Barriers of the CNS  provides a dedicated avenue for the dissemination of research into all molecular, physiological and pharmacological aspects of brain fluids and barrier systems and their role in neurological disorders. Brain fluids and barriers in general, are subject areas that have not previously had a specialist publishing platform. Until recently, articles have been published in a variety of different journals. This journal provides a dedicated platform, offering high-quality peer-review of manuscripts. It brings together basic science and clinical experts in brain fluids and barrier systems, promotes synthesis, dialogue and translational research.


Fluids and Barriers of the CNS is an official journal for the following academic societies (members are eligible for a 15% discount on the article-processing charge):

Eligibility: Society members should request a waiver at the “APC Agreement” stage of submission before confirming they are a member of either the ISHCSF/IBBS and eligible for a 15% APC-discount (text box provided). Society members should log into the membership area of their society to obtain their institutional reference code to enter in the payment options page.

Article processing charges (APC)

Authors who publish open access in Fluids and Barriers of the CNS are required to pay an article processing charge (APC). The APC price will be determined from the date on which the article is accepted for publication.

The current APC, subject to VAT or local taxes where applicable, is: £2490.00/$3290.00/€2790.00

Visit our open access support portal and our Journal Pricing FAQs for further information.

Open access funding

Visit Springer Nature’s open access funding & support services for information about research funders and institutions that provide funding for APCs.

Springer Nature offers agreements that enable institutions to cover open access publishing costs. Learn more about our open access agreements to check your eligibility and discover whether this journal is included.

Springer Nature offers APC waivers and discounts for articles published in our fully open access journals whose corresponding authors are based in the world’s lowest income countries (see our APC waivers and discounts policy for further information). Requests for APC waivers and discounts from other authors will be considered on a case-by-case basis, and may be granted in cases of financial need (see our open access policies for journals for more information). All applications for discretionary APC waivers and discounts should be made at the point of manuscript submission; requests made during the review process or after acceptance are unable to be considered.

Open access

All articles published by Fluids and Barriers of the CNS are made freely and permanently accessible online immediately upon publication, without subscription charges or registration barriers. Further information about open access can be found here.

As authors of articles published in Fluids and Barriers of the CNS you are the copyright holders of your article and have granted to any third party, in advance and in perpetuity, the right to use, reproduce or disseminate your article, according to the BMC license agreement.

For those of you who are US government employees or are prevented from being copyright holders for similar reasons, BMC can accommodate non-standard copyright lines. Please contact us if further information is needed.

Indexing services

All articles published in Fluids and Barriers of the CNS are included in:

  • CAS
  • Citebase
  • DOAJ
  • Embase
  • OAIster
  • PubMed
  • PubMed Central
  • Scopus
  • Zetoc

The full text of all articles is deposited in digital archives around the world to guarantee long-term digital preservation. You can also access all articles published by BioMed Central on SpringerLink.
We are working closely with relevant indexing services including Web of Science (Clarivate Analytics) to ensure that articles published in Fluids and Barriers of the CNS will be available in their databases when appropriate.

Peer-review policy

Peer-review is the system used to assess the quality of a manuscript before it is published. Independent researchers in the relevant research area assess submitted manuscripts for originality, validity and significance to help editors determine whether the manuscript should be published in their journal. You can read more about the peer-review process here.

Fluids and Barriers of the CNS operates a single-blind peer-review system, where the reviewers are aware of the names and affiliations of the authors, but the reviewer reports provided to authors are anonymous.

Publication of research articles by Fluids and Barriers of the CNS is dependent primarily on their scientific validity and coherence as judged by our external expert editors and/or peer reviewers, who will also assess whether the writing is comprehensible and whether the work represents a useful contribution to the field.

Editorial policies

All manuscripts submitted to Fluids and Barriers of the CNS should adhere to BioMed Central's editorial policies.

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Citing articles in Fluids and Barriers of the CNS

Articles in Fluids and Barriers of the CNS  should be cited in the same way as articles in a traditional journal. Because articles are not printed, they do not have page numbers; instead, they are given a unique article number.

Article citations follow this format:

Authors: Title. Fluids and Barriers of the CNS [year], [volume number]:[article number].

e.g. Roberts LD, Hassall DG, Winegar DA, Haselden JN, Nicholls AW, Griffin JL: Increased hepatic oxidative metabolism distinguishes the action of Peroxisome Proliferator-Activated Receptor delta from Peroxisome Proliferator-Activated Receptor gamma in the Ob/Ob mouse. Fluids and Barriers of the CNS 2009, 1:115.

refers to article 115 from Volume 1 of the journal.

Appeals and complaints

Authors who wish to appeal a rejection or make a complaint should follow the procedure outlined in the BMC Editorial Policies.

Benefits of publishing with BMC

High visibility

Fluids and Barriers of the CNS's open access policy allows maximum visibility of articles published in the journal as they are available to a wide, global audience. 

Speed of publication

Fluids and Barriers of the CNS offers a fast publication schedule whilst maintaining rigorous peer review; all articles must be submitted online, and peer review is managed fully electronically (articles are distributed in PDF form, which is automatically generated from the submitted files). Articles will be published with their final citation after acceptance, in both fully browsable web form, and as a formatted PDF.


Online publication in Fluids and Barriers of the CNS gives you the opportunity to publish large datasets, large numbers of color illustrations and moving pictures, to display data in a form that can be read directly by other software packages so as to allow readers to manipulate the data for themselves, and to create all relevant links (for example, to PubMed, to sequence and other databases, and to other articles).

Promotion and press coverage

Articles published in Fluids and Barriers of the CNS are included in article alerts and regular email updates. Some may be highlighted on Fluids and Barriers of the CNS’s pages and on the BMC homepage.

In addition, articles published in Fluids and Barriers of the CNS may be promoted by press releases to the general or scientific press. These activities increase the exposure and number of accesses for articles published in Fluids and Barriers of the CNS. A list of articles recently press-released by journals published by BMC is available here.


As an author of an article published in Fluids and Barriers of the CNS you retain the copyright of your article and you are free to reproduce and disseminate your work (for further details, see the BMC license agreement).

For further information about the advantages of publishing in a journal from BMC, please click here.