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  1. The meninges, formed by dura, arachnoid and pia mater, cover the central nervous system and provide important barrier functions. Located between arachnoid and pia mater, the cerebrospinal fluid (CSF)-filled su...

    Authors: Diego Rossinelli, Hanspeter Esriel Killer, Peter Meyer, Graham Knott, Gilles Fourestey, Vartan Kurtcuoglu, Corina Kohler, Philipp Gruber, Luca Remonda, Albert Neutzner and Jatta Berberat
    Citation: Fluids and Barriers of the CNS 2023 20:21
    Content type: Research Published on:

  3. Choroid plexuses (ChPs) are intraventricular structures mainly composed by specialized epithelial cells interconnected by tight junctions that establish the blood-cerebrospinal fluid (CSF) barrier. ChPs are es...

    Authors: Valentina Scarpetta, Felipe Bodaleo, Chiara Salio, Amit Agarwal, Marco Sassoè-Pognetto and Annarita Patrizi
    Citation: Fluids and Barriers of the CNS 2023 20:19
    Content type: Research Published on:

  4. The mechanisms of cerebrospinal fluid (CSF) production by the ventricular choroid plexus (ChP) have not been fully deciphered. One prominent hypothesized mechanism is trans-epithelial water transport mediated ...

    Authors: Pooya Razzaghi Khamesi, Vasileios Charitatos, Eva K. Heerfordt, Nanna MacAulay and Vartan Kurtcuoglu
    Citation: Fluids and Barriers of the CNS 2023 20:18
    Content type: Research Published on:

  5. Electronic nicotine delivery systems (ENDS), also commonly known as electronic cigarettes (e-cigs) are considered in most cases as a safer alternative to tobacco smoking and therefore have become extremely pop...

    Authors: Sabrina Rahman Archie, Ali Ehsan Sifat, Yong Zhang, Heidi Villalba, Sejal Sharma, Saeideh Nozohouri and Thomas J. Abbruscato
    Citation: Fluids and Barriers of the CNS 2023 20:17
    Content type: Research Published on:

  6. In the cerebrospinal fluid (CSF) dynamics, the pulsations of cerebral arteries and brain is considered the main driving force for the reciprocating bidirectional CSF movements. However, measuring these complex...

    Authors: Shigeki Yamada, Shinnosuke Hiratsuka, Tomohiro Otani, Satoshi Ii, Shigeo Wada, Marie Oshima, Kazuhiko Nozaki and Yoshiyuki Watanabe
    Citation: Fluids and Barriers of the CNS 2023 20:16
    Content type: Research Published on:

  7. Hypertriglyceridemia is closely linked to atherosclerosis related inflammatory processes and blood–brain barrier (BBB) dysfunction. Using apolipoprotein B-100 (APOB-100) transgenic mice, an animal model of chr...

    Authors: Beáta Barabási, Lilla Barna, Ana Raquel Santa-Maria, András Harazin, Réka Molnár, András Kincses, Judit P. Vigh, Brigitta Dukay, Miklós Sántha, Melinda E. Tóth, Fruzsina R. Walter, Mária A. Deli and Zsófia Hoyk
    Citation: Fluids and Barriers of the CNS 2023 20:15
    Content type: Research Published on:

  8. Incomplete recovery of blood–brain barrier (BBB) function contributes to stroke outcomes. How the BBB recovers after stroke remains largely unknown. Emerging evidence suggests that epigenetic factors play a si...

    Authors: Chelsea M. Phillips, Svetlana M. Stamatovic, Richard F. Keep and Anuska V. Andjelkovic
    Citation: Fluids and Barriers of the CNS 2023 20:14
    Content type: Research Published on:

  9. Potential biomarkers for neuropsychiatric disorders are cerebrospinal fluid (CSF) monoamines and their corresponding precursors and metabolites. During CSF sampling, CSF flows towards the lumbar sampling site ...

    Authors: Celien Tigchelaar, Willemien D. Muller, Sawal D. Atmosoerodjo, Klaas J. Wardenaar, Ido P. Kema, Anthony R. Absalom and Martijn van Faassen
    Citation: Fluids and Barriers of the CNS 2023 20:13
    Content type: Research Published on:

  10. The three-layered meninges cover and protect the central nervous system and form the interface between cerebrospinal fluid and the brain. They are host to a lymphatic system essential for maintaining fluid dyn...

    Authors: Melanie Neutzner, Corina Kohler, Stephan Frank, Hanspeter E. Killer and Albert Neutzner
    Citation: Fluids and Barriers of the CNS 2023 20:12
    Content type: Research Published on:

  11. Regulation of cerebral blood flow (CBF) directly influence brain functions and dysfunctions and involves complex mechanisms, including neurovascular coupling (NVC). It was suggested that the serine protease ti...

    Authors: Jonathane Furon, Mervé Yetim, Elsa Pouettre, Sara Martinez de Lizarrondo, Eric Maubert, Yannick Hommet, Laurent Lebouvier, Ze Zheng, Carine Ali and Denis Vivien
    Citation: Fluids and Barriers of the CNS 2023 20:11
    Content type: Research Published on:

  12. Brain microvascular endothelial cells (BMECs) play a major role in the blood–brain barrier (BBB), and are critical for establishing an in vitro BBB model. Currently, iPSC-derived BMECs (iBMECs) have been used ...

    Authors: Hongyan Zhang, Tomoko Yamaguchi and Kenji Kawabata
    Citation: Fluids and Barriers of the CNS 2023 20:10
    Content type: Research Published on:

  13. Age-related changes in the cerebrovasculature, including blood–brain barrier (BBB) disruption and vascular dementia, are emerging as potential risks for many neurodegenerative diseases. Therefore, the endothel...

    Authors: Hyejeong Kim, Minyoung Noh, Haiying Zhang, Yeomyeong Kim, Songyi Park, Jeongeun Park and Young-Guen Kwon
    Citation: Fluids and Barriers of the CNS 2023 20:9
    Content type: Research Published on:

  14. The multidrug resistance (MDR) transporters, P-glycoprotein (P-gp, encoded by ABCB1) and breast cancer resistance protein (BCRP/ABCG2) contribute to the blood–brain barrier (BBB), protecting the brain from drug e...

    Authors: Phetcharawan Lye, Enrrico Bloise and Stephen G. Matthews
    Citation: Fluids and Barriers of the CNS 2023 20:8
    Content type: Research Published on:

  15. Idiopathic normal pressure hydrocephalus (iNPH) is a progressive and partially reversible form of dementia, characterized by impaired interactions between multiple brain regions. Because of the presence of com...

    Authors: Sara Fabbro, Daniele Piccolo, Maria Caterina Vescovi, Daniele Bagatto, Yan Tereshko, Enrico Belgrado, Marta Maieron, Maria Cristina De Colle, Miran Skrap and Francesco Tuniz
    Citation: Fluids and Barriers of the CNS 2023 20:7
    Content type: Research Published on:

  16. Pathological cerebral conditions may manifest in altered composition of the cerebrospinal fluid (CSF). Although diagnostic CSF analysis seeks to establish pathological disturbances in the brain proper, CSF is ...

    Authors: Nina Rostgaard, Markus Harboe Olsen, Maud Ottenheijm, Lylia Drici, Anja Hviid Simonsen, Peter Plomgaard, Hanne Gredal, Helle Harding Poulsen, Henrik Zetterberg, Kaj Blennow, Steen Gregers Hasselbalch, Nanna MacAulay and Marianne Juhler
    Citation: Fluids and Barriers of the CNS 2023 20:6
    Content type: Research Published on:

  17. Detecting changes in pulsatile cerebrospinal fluid (CSF) flow may assist clinical management decisions, but spinal CSF flow is relatively understudied. Traumatic spinal cord injuries (SCI) often cause spinal c...

    Authors: Madeleine Amy Bessen, Christine Diana Gayen, Ryan David Quarrington, Angela Catherine Walls, Anna Victoria Leonard, Vartan Kurtcuoglu and Claire Frances Jones
    Citation: Fluids and Barriers of the CNS 2023 20:5
    Content type: Research Published on:

  19. The Hydrocephalus Association (HA) workshop, Driving Common Pathways: Extending Insights from Posthemorrhagic Hydrocephalus, was held on November 4 and 5, 2019 at Washington University in St. Louis. The worksh...

    Authors: Jason K. Karimy, Jessie C. Newville, Cameron Sadegh, Jill A. Morris, Edwin S. Monuki, David D. Limbrick Jr., James P. McAllister II, Jenna E. Koschnitzky, Maria K. Lehtinen and Lauren L. Jantzie
    Citation: Fluids and Barriers of the CNS 2023 20:4
    Content type: Review Published on:

  20. Impaired cerebrospinal fluid (CSF) homeostasis is central to the pathogenesis of idiopathic intracranial hypertension (IIH), although the precise mechanisms involved are still not completely understood. The ai...

    Authors: Sinah Engel, Johannes Halcour, Erik Ellwardt, Timo Uphaus, Falk Steffen, Frauke Zipp, Stefan Bittner and Felix Luessi
    Citation: Fluids and Barriers of the CNS 2023 20:3
    Content type: Research Published on:

  21. The detailed mechanisms by which the transferrin receptor (TfR) and associated ligands traffic across brain capillary endothelial cells (BECs) of the CNS-protective blood–brain barrier constitute an important ...

    Authors: Simone S. E. Nielsen, Mikkel R. Holst, Kristine Langthaler, Elisabeth Helena Bruun, Birger Brodin and Morten S. Nielsen
    Citation: Fluids and Barriers of the CNS 2023 20:2
    Content type: Research Published on:

  22. Our previous study demonstrated that M1 macrophages could impair tight junctions (TJs) between vascular endothelial cells by secreting interleukin-6 (IL-6) after spinal cord injury (SCI). Tocilizumab, as a hum...

    Authors: Yang Luo, Fei Yao, Yi Shi, Zhenyu Zhu, Zhaoming Xiao, Xingyu You, Yanchang Liu, Shuisheng Yu, Dasheng Tian, Li Cheng, Meige Zheng and Juehua Jing
    Citation: Fluids and Barriers of the CNS 2023 20:1
    Content type: Research Published on:

  23. Despite the great potential of FUS-BBB disruption (FUS-BBBD), it is still controversial whether FUS-BBBD acts as an inducing factor of neuro-inflammation or not, and the biological responses after FUS-BBBD tri...

    Authors: Hyo Jin Choi, Mun Han, Hyeon Seo, Chan Yuk Park, Eun-Hee Lee and Juyoung Park
    Citation: Fluids and Barriers of the CNS 2022 19:103
    Content type: Research Published on:

  24. In patients with central nervous system (CNS) infections identification of the causative pathogen is important for treatment. Metagenomic next-generation sequencing techniques are increasingly being applied to...

    Authors: Cormac M. Kinsella, Arthur W. D. Edridge, Ingeborg E. van Zeggeren, Martin Deijs, Diederik van de Beek, Matthijs C. Brouwer and Lia van der Hoek
    Citation: Fluids and Barriers of the CNS 2022 19:102
    Content type: Research Published on:

  25. Cerebrospinal fluid (CSF) is an essential and critical component of the central nervous system (CNS). According to the concept of the “third circulation” originally proposed by Cushing, CSF is mainly produced ...

    Authors: Guojun Liu, Antonio Ladrón-de-Guevara, Yara Izhiman, Maiken Nedergaard and Ting Du
    Citation: Fluids and Barriers of the CNS 2022 19:101
    Content type: Review Published on:

  26. Cervical blood and cerebrospinal fluid (CSF) flow rates can be quantified with Phase-contrast (PC) MRI, which is routinely used for clinical studies. Previous MRI studies showed that venous and CSF flow altera...

    Authors: Maria Marcella Laganà, Sonia Di Tella, Francesca Ferrari, Laura Pelizzari, Marta Cazzoli, Noam Alperin, Ning Jin, Domenico Zacà, Giuseppe Baselli and Francesca Baglio
    Citation: Fluids and Barriers of the CNS 2022 19:100
    Content type: Research Published on:

  27. Treatment with amyloid-β (Aβ) targeting antibodies is a promising approach to remove Aβ brain pathology in Alzheimer's disease (AD) and possibly even slow down or stop progression of the disease. One of the ma...

    Authors: Ulrika Julku, Mengfei Xiong, Elin Wik, Sahar Roshanbin, Dag Sehlin and Stina Syvänen
    Citation: Fluids and Barriers of the CNS 2022 19:99
    Content type: Research Published on:

  28. Glucose transport from the blood into the brain is tightly regulated by brain microvascular endothelial cells (BMEC), which also use glucose as their primary energy source. To study how BMEC glucose transport ...

    Authors: Callie M. Weber, Bilal Moiz, Sophia M. Zic, Viviana Alpízar Vargas, Andrew Li and Alisa Morss Clyne
    Citation: Fluids and Barriers of the CNS 2022 19:98
    Content type: Research Published on:

  29. Unlike other proteins that exhibit a diffusion pattern after intracerebral injection, laminin displays a vascular pattern. It remains unclear if this unique vascular pattern is caused by laminin-receptor inter...

    Authors: Jingsong Ruan, Karen K. McKee, Peter D. Yurchenco and Yao Yao
    Citation: Fluids and Barriers of the CNS 2022 19:97
    Content type: Research Published on:

  30. A reduced amyloid-β (Aβ)42/40 peptide ratio in blood plasma represents a peripheral biomarker of the cerebral amyloid pathology observed in Alzheimer’s disease brains. The magnitude of the measurable effect in...

    Authors: Hans-Wolfgang Klafki, Barbara Morgado, Oliver Wirths, Olaf Jahn, Chris Bauer, Hermann Esselmann, Johannes Schuchhardt and Jens Wiltfang
    Citation: Fluids and Barriers of the CNS 2022 19:96
    Content type: Research Published on:

  31. Hydrocephalus is characterized by abnormal accumulation of cerebrospinal fluid in the cerebral ventricles and causes motor impairments. The mechanisms underlying the motor changes remain elusive. Enlargement o...

    Authors: Li-Jin Chen, Jeng-Rung Chen and Guo-Fang Tseng
    Citation: Fluids and Barriers of the CNS 2022 19:95
    Content type: Research Published on:

  32. Cerebral aneurysms are more likely to form at bifurcations in the vasculature, where disturbed fluid is prevalent due to flow separation at sufficiently high Reynolds numbers. While previous studies have demon...

    Authors: Nesrine Bouhrira, Brandon J. DeOre, Kiet A. Tran and Peter A. Galie
    Citation: Fluids and Barriers of the CNS 2022 19:94
    Content type: Research Published on:

  33. Disruption of brain barriers is considered to be involved in the pathogenesis of neuronal surface antibody-associated autoimmune encephalitis (NSAE), but few studies have focused on their relationship. We aime...

    Authors: Qi-Lun Lai, Meng-Ting Cai, Yang Zheng, Gao-Li Fang, Bing-Qing Du, Chun-Hong Shen, Jia-Jia Wang, Qin-Jie Weng and Yin-Xi Zhang
    Citation: Fluids and Barriers of the CNS 2022 19:93
    Content type: Research Published on:

  34. Folates are a family of B9 vitamins that serve as one-carbon donors critical to biosynthetic processes required for the development and function of the central nervous system (CNS) in mammals. Folate transport...

    Authors: Vishal Sangha, Md. Tozammel Hoque, Jeffrey T. Henderson and Reina Bendayan
    Citation: Fluids and Barriers of the CNS 2022 19:92
    Content type: Brief Report Published on:

  35. Authors: Yong Zhang, Sabrina Rahman Archie, Yashwardhan Ghanwatkar, Sejal Sharma, Saeideh Nozohouri, Elizabeth Burks, Alexander Mdzinarishvili, Zijuan Liu and Thomas J. Abbruscato
    Citation: Fluids and Barriers of the CNS 2022 19:91
    Content type: Correction Published on:

    The original article was published in Fluids and Barriers of the CNS 2022 19:46

  36. Apparent permeability of the blood brain barrier to hydrophilic markers has been shown to be higher in the developing brain. Apart from synthesis in situ, any substance detected in the brain parenchyma can origin...

    Authors: Fiona Qiu, Yifan Huang, Norman R. Saunders, Mark D. Habgood and Katarzyna M. Dziegielewska
    Citation: Fluids and Barriers of the CNS 2022 19:90
    Content type: Research Published on:

  37. Idiopathic normal pressure hydrocephalus (iNPH) is a multifactorial disease presenting with a classical symptom triad of cognitive decline, gait disturbance and urinary incontinence. The symptoms can be allevi...

    Authors: Jani Sirkka, Laura Säisänen, Petro Julkunen, Mervi Könönen, Elisa Kallioniemi, Ville Leinonen and Nils Danner
    Citation: Fluids and Barriers of the CNS 2022 19:89
    Content type: Research Published on:

  38. While aging is the main risk factor for Alzheimer´s disease (AD), emerging evidence suggests that metabolic alterations such as type 2 diabetes (T2D) are also major contributors. Indeed, several studies have d...

    Authors: Maria Vargas-Soria, Juan Jose Ramos-Rodriguez, Angel del Marco, Carmen Hierro-Bujalance, Maria Jose Carranza-Naval, Maria Calvo-Rodriguez, Susanne J. van Veluw, Alan W. Stitt, Rafael Simó, Brian J. Bacskai, Carmen Infante-Garcia and Monica Garcia-Alloza
    Citation: Fluids and Barriers of the CNS 2022 19:88
    Content type: Research Published on:

  39. The blood–brain barrier (BBB) plays a pivotal role in brain health and disease. In the BBB, brain microvascular endothelial cells (BMECs) are connected by tight junctions which regulate paracellular transport,...

    Authors: Raleigh M. Linville, Matthew B. Sklar, Gabrielle N. Grifno, Renée F. Nerenberg, Justin Zhou, Robert Ye, Jackson G. DeStefano, Zhaobin Guo, Ria Jha, John J. Jamieson, Nan Zhao and Peter C. Searson
    Citation: Fluids and Barriers of the CNS 2022 19:87
    Content type: Research Published on:

  41. Intracranial pressure (ICP) has been thought to vary diurnally. This study evaluates diurnal ICP measurements and quantifies changes in ICP occurring with changes in body posture in active idiopathic intracran...

    Authors: James L Mitchell, Rebecca Buckham, Hannah Lyons, Jessica K Walker, Andreas Yiangou, Matilde Sassani, Mark Thaller, Olivia Grech, Zerin Alimajstorovic, Marianne Julher, Georgios Tsermoulas, Kristian Brock, Susan P Mollan and Alexandra J Sinclair
    Citation: Fluids and Barriers of the CNS 2022 19:85
    Content type: Research Published on:

  43. Authors: Vincent Zuba, Jonathane Furon, Mathys Bellemain-Sagnard, Sara Martinez de Lazarrondo, Laurent Lebouvier, Marina Rubio, Yannick Hommet, Maxime Gauberti, Denis Vivien and Carine Ali
    Citation: Fluids and Barriers of the CNS 2022 19:83
    Content type: Correction Published on:

    The original article was published in Fluids and Barriers of the CNS 2022 19:80

  44. Impaired cerebrospinal fluid (CSF) dynamics may contribute to the pathophysiology of neurodegenerative diseases, and play a crucial role in brain health in older people; nonetheless, such age-related changes h...

    Authors: Yosuke Hidaka, Mamoru Hashimoto, Takashi Suehiro, Ryuji Fukuhara, Tomohisa Ishikawa, Naoko Tsunoda, Asuka Koyama, Kazuki Honda, Yusuke Miyagawa, Kazuhiro Yoshiura, Shuken Boku, Kazunari Ishii, Manabu Ikeda and Minoru Takebayashi
    Citation: Fluids and Barriers of the CNS 2022 19:82
    Content type: Research Published on:

  45. Bacterial meningitis is a life-threatening disease that occurs when pathogens such as Neisseria meningitidis cross the meningeal blood cerebrospinal fluid barrier (mBCSFB) and infect the meninges. Due to the huma...

    Authors: Leo M. Endres, Marvin Jungblut, Mustafa Divyapicigil, Markus Sauer, Christian Stigloher, Myron Christodoulides, Brandon J. Kim and Alexandra Schubert-Unkmeir
    Citation: Fluids and Barriers of the CNS 2022 19:81
    Content type: Research Published on:

  46. In the vascular compartment, the serine protease tissue-type plasminogen activator (tPA) promotes fibrinolysis, justifying its clinical use against vasculo-occlusive diseases. Accumulating evidence shows that ...

    Authors: Vincent Zuba, Jonathane Furon, Mathys Bellemain-Sagnard, Sara Martinez de Lizarrondo, Laurent Lebouvier, Marina Rubio, Yannick Hommet, Maxime Gauberti, Denis Vivien and Carine Ali
    Citation: Fluids and Barriers of the CNS 2022 19:80
    Content type: Research Published on:

    The Correction to this article has been published in Fluids and Barriers of the CNS 2022 19:83

  47. The blood brain barrier (BBB) limits the therapeutic perspective for central nervous system (CNS) disorders. Previously we found an anti-mouse transferrin receptor (TfR) VHH (Nb62) that was able to deliver a b...

    Authors: Yessica Wouters, Tom Jaspers, Laura Rué, Lutgarde Serneels, Bart De Strooper and Maarten Dewilde
    Citation: Fluids and Barriers of the CNS 2022 19:79
    Content type: Research Published on:

  48. The composition of tissue obstructing neuroprosthetic devices is largely composed of inflammatory cells with a significant astrocyte component. In a first-of-its-kind study, we profile the astrocyte phenotypes...

    Authors: Fatemeh Khodadadei, Rooshan Arshad, Diego M. Morales, Jacob Gluski, Neena I. Marupudi, James P. McAllister II, David D. Limbrick Jr. and Carolyn A. Harris
    Citation: Fluids and Barriers of the CNS 2022 19:78
    Content type: Research Published on:

  49. The hormone leptin exerts its function in the brain to reduce food intake and increase energy expenditure to prevent obesity. However, most obese subjects reflect the resistance to leptin even with elevated se...

    Authors: Yajuan Shi, Hyosung Kim, Catherine A. Hamann, Elizabeth M. Rhea, Jonathan M. Brunger and Ethan S. Lippmann
    Citation: Fluids and Barriers of the CNS 2022 19:77
    Content type: Research Published on:

  50. Mucopolysaccharidoses comprise a set of genetic diseases marked by an enzymatic dysfunction in the degradation of glycosaminoglycans in lysosomes. There are eight clinically distinct types of mucopolysaccharid...

    Authors: Onur Sahin, Hannah P. Thompson, Grant W. Goodman, Jun Li and Akihiko Urayama
    Citation: Fluids and Barriers of the CNS 2022 19:76
    Content type: Review Published on:
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  • ISSN: 2045-8118 (electronic)

Fluids and Barriers of the CNS

ISSN: 2045-8118