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Fluids and Barriers of the CNS

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  1. Content type: Research

    Many radiological signs are known for the diagnosis of idiopathic normal pressure hydrocephalus (iNPH). However, there is little information about these signs in the pre-symptomatic phase. For pathophysiologic...

    Authors: D. C. Engel, S. D. Adib, M. U. Schuhmann and C. Brendle

    Citation: Fluids and Barriers of the CNS 2018 15:5

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  2. Content type: Research

    The blood–brain barrier (BBB) severely limits the entry of systemically administered drugs including chemotherapy to the brain. In rodents, regadenoson activation of adenosine A2A receptors causes transient BBB d...

    Authors: Sadhana Jackson, Jon Weingart, Edjah K. Nduom, Thura T. Harfi, Richard T. George, Dorothea McAreavey, Xiaobu Ye, Nicole M. Anders, Cody Peer, William D. Figg, Mark Gilbert, Michelle A. Rudek and Stuart A. Grossman

    Citation: Fluids and Barriers of the CNS 2018 15:2

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  3. Content type: Correction

    After publication of the article [1], it has been brought to our attention that there are some errors in the formatting of names in the final version of the article.

    Authors: John Greenwood, Margareta Hammarlund-Udenaes, Hazel C. Jones, Alan W. Stitt, Roosmarijn E. Vandenbroucke, Ignacio A. Romero, Matthew Campbell, Gert Fricker, Birger Brodin, Heiko Manninga, Pieter J. Gaillard, Markus Schwaninger, Carl Webster, Krzysztof B. Wicher and Michel Khrestchatisky

    Citation: Fluids and Barriers of the CNS 2018 15:3

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    The original article was published in Fluids and Barriers of the CNS 2017 14:31

  4. Content type: Research

    para-Tyramine (p-TA) is a biogenic amine which is involved in multiple neuronal signal transductions. Since the concentration of p-TA in dog cerebrospinal fluid (CSF) has been reported to be ...

    Authors: Shin-ichi Akanuma, Yuhei Yamazaki, Yoshiyuki Kubo and Ken-ichi Hosoya

    Citation: Fluids and Barriers of the CNS 2018 15:1

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  5. Content type: Research

    The spinal subarachnoid space (SSS) has a complex 3D fluid-filled geometry with multiple levels of anatomic complexity, the most salient features being the spinal cord and dorsal and ventral nerve rootlets. An...

    Authors: Lucas R. Sass, Mohammadreza Khani, Gabryel Connely Natividad, R. Shane Tubbs, Olivier Baledent and Bryn A. Martin

    Citation: Fluids and Barriers of the CNS 2017 14:36

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  6. Content type: Research

    Neuroinflammation has been implicated in the pathophysiology of post-hemorrhagic hydrocephalus (PHH) of prematurity, but no comprehensive analysis of signaling molecules has been performed using human cerebros...

    Authors: Gakwaya Habiyaremye, Diego M. Morales, Clinton D. Morgan, James P. McAllister, Travis S. CreveCoeur, Rowland H. Han, Mohamed Gabir, Brandon Baksh, Deanna Mercer and David D. Limbrick Jr.

    Citation: Fluids and Barriers of the CNS 2017 14:35

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  7. Content type: Research

    We previously described inflammatory cerebrospinal fluid (CSF) alterations in a subgroup of patients with schizophreniform disorders and the synthesis of polyspecific intrathecal antibodies against different n...

    Authors: Dominique Endres, Daniela Huzly, Rick Dersch, Oliver Stich, Benjamin Berger, Florian Schuchardt, Evgeniy Perlov, Nils Venhoff, Sabine Hellwig, Bernd L. Fiebich, Daniel Erny, Tilman Hottenrott and Ludger Tebartz van Elst

    Citation: Fluids and Barriers of the CNS 2017 14:34

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  8. Content type: Review

    Opioids are currently the primary treatment method used to manage both acute and chronic pain. In the past two to three decades, there has been a surge in the use, abuse and misuse of opioids. The mechanism by...

    Authors: Charles P. Schaefer, Margaret E. Tome and Thomas P. Davis

    Citation: Fluids and Barriers of the CNS 2017 14:32

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  9. Content type: Research

    Symptomatic intracerebral haemorrhage (sICH) following tissue-type plasminogen activator (rt-PA) administration is the most feared and lethal complication of thrombolytic therapy for ischaemic stroke, creating...

    Authors: Be’eri Niego, Brad R. S. Broughton, Heidi Ho, Christopher G. Sobey and Robert L. Medcalf

    Citation: Fluids and Barriers of the CNS 2017 14:33

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  10. Content type: Review

    This is a report on the CNS barrier congress held in London, UK, March 22–23rd 2017 and sponsored by Kisaco Research Ltd. The two 1-day sessions were chaired by John Greenwood and Margareta Hammarlund-Udenaes,...

    Authors: John Greenwood, Margareta Hammarlund-Udenaes, Hazel C. Jones, Alan W. Stitt, Roosmarijn E. Vandenbroucke, Ignacio A. Romero, Matthew Campbell, Gert Fricker, Birger Brodin, Heiko Manninga, Pieter J. Gaillard, Markus Schwaninger, Carl Webster, Krzysztof B. Wicher and Michel Khrestchatisky

    Citation: Fluids and Barriers of the CNS 2017 14:31

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    The Correction to this article has been published in Fluids and Barriers of the CNS 2018 15:3

  11. Content type: Research

    Atenolol, a hydrophilic beta blocker, has been used as a model drug for studying passive permeability of biological membranes such as the blood–brain barrier (BBB) and the intestinal epithelium. However, the e...

    Authors: Xiaomei Chen, Tim Slättengren, Elizabeth C. M. de Lange, David E. Smith and Margareta Hammarlund-Udenaes

    Citation: Fluids and Barriers of the CNS 2017 14:30

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  12. Content type: Meeting abstracts

    Authors: Andrzej Małecki, Janina Skipor-Lahuta, Michal Toborek, N. Joan Abbott, David A. Antonetti, Enming Joe Su, Daniel A. Lawrence, Müge Atış, Uğur Akcan, Canan Uğur Yılmaz, Nurcan Orhan, Poyraz Düzgün, Umut Deniz Ceylan, Nadir Arıcan, Serçin Karahüseyinoğlu, Gizem Nur Şahin…

    Citation: Fluids and Barriers of the CNS 2017 14(Suppl 2):27

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    This article is part of a Supplement: Volume 14 Supplement 2

  13. Content type: Research

    Magnetic resonance imaging (MRI) does not only ascertain morphological features, but also measures physiological properties such as fluid velocity or pressure gradient. The purpose of this study was to investi...

    Authors: Ken Takizawa, Mitsunori Matsumae, Naokazu Hayashi, Akihiro Hirayama, Satoshi Yatsushiro and Kagayaki Kuroda

    Citation: Fluids and Barriers of the CNS 2017 14:29

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  14. Content type: Correction

    After publication of the article [1], it has been brought to our attention that the full funding acknowledgement is missing from the original article.

    Authors: Amauri Dalla Corte, Carolina F. M. de Souza, Maurício Anés, Fabio K. Maeda, Armelle Lokossou, Leonardo M. Vedolin, Maria Gabriela Longo, Monica M. Ferreira, Solanger G. P. Perrone, Olivier Balédent and Roberto Giugliani

    Citation: Fluids and Barriers of the CNS 2017 14:28

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    The original article was published in Fluids and Barriers of the CNS 2017 14:23

  15. Content type: Research

    Cisplatin neuro-, oto-, and nephrotoxicity are major problems in children with malignant tumors, including medulloblastoma, negatively impacting educational achievement, socioemotional development, and overall...

    Authors: Edit Dósa, Krisztina Heltai, Tamás Radovits, Gabriella Molnár, Judit Kapocsi, Béla Merkely, Rongwei Fu, Nancy D. Doolittle, Gerda B. Tóth, Zachary Urdang and Edward A. Neuwelt

    Citation: Fluids and Barriers of the CNS 2017 14:26

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  16. Content type: Research

    A classification of cardiac- and respiratory-driven components of cerebrospinal fluid (CSF) motion has been demonstrated using echo planar imaging and time-spatial labeling inversion pulse techniques of magnet...

    Authors: Ken Takizawa, Mitsunori Matsumae, Saeko Sunohara, Satoshi Yatsushiro and Kagayaki Kuroda

    Citation: Fluids and Barriers of the CNS 2017 14:25

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  17. Content type: Research

    Very little is known about the incidence and prevalence of hydrocephalus in patients with mucopolysaccharidoses (MPS). The biggest challenge is to distinguish communicating hydrocephalus from ventricular dilat...

    Authors: Amauri Dalla Corte, Carolina F. M. de Souza, Maurício Anés, Fabio K. Maeda, Armelle Lokossou, Leonardo M. Vedolin, Maria Gabriela Longo, Monica M. Ferreira, Solanger G. P. Perrone, Olivier Balédent and Roberto Giugliani

    Citation: Fluids and Barriers of the CNS 2017 14:23

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    The Correction to this article has been published in Fluids and Barriers of the CNS 2017 14:28

  18. Content type: Research

    Invasive tests measuring resistance to cerebral spinal fluid (CSF) outflow and the effect of temporary drainage of CSF are used to select candidates affected by idiopathic normal pressure hydrocephalus (iNPH) ...

    Authors: Francesco Tuniz, Maria Caterina Vescovi, Daniele Bagatto, Daniela Drigo, Maria Cristina De Colle, Marta Maieron and Miran Skrap

    Citation: Fluids and Barriers of the CNS 2017 14:24

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  19. Content type: Research

    Neoplastic invasion into leptomeninges and subarachnoid space, resulting in neoplastic meningitis (NM) is a fatal complication of advanced solid and hematological neoplasms. Identification of malignant involve...

    Authors: Catharina Conrad, Kristina Dorzweiler, Miles A. Miller, Douglas A. Lauffenburger, Herwig Strik and Jörg W. Bartsch

    Citation: Fluids and Barriers of the CNS 2017 14:22

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  20. Content type: Research

    The endothelial cells that form the lumen of capillaries and microvessels are an important component of the blood–brain barrier. Cell phenotype is regulated by transducing a range of biomechanical and biochemi...

    Authors: Jackson G. DeStefano, Zinnia S. Xu, Ashley J. Williams, Nahom Yimam and Peter C. Searson

    Citation: Fluids and Barriers of the CNS 2017 14:20

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  21. Content type: Erratum

    Citation: Fluids and Barriers of the CNS 2017 14:21

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    The original article was published in Fluids and Barriers of the CNS 2015 12:O35

    The original article was published in Fluids and Barriers of the CNS 2015 12:O12

  22. Content type: Review

    Despite decades of research, no compelling non-surgical therapies have been developed for foetal hydrocephalus. So far, most efforts have pointed to repairing disturbances in the cerebrospinal fluid (CSF) flow...

    Authors: M. Guerra, J. L. Blázquez and E. M. Rodríguez

    Citation: Fluids and Barriers of the CNS 2017 14:19

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  23. Content type: Short Paper

    There is evidence that patients with multiple sclerosis (MS) and hydrocephalus share some common pathophysiological mechanisms. Alterations in CSF pressure are known to affect cerebral venous sinus geometry. T...

    Authors: Grant A. Bateman, Jeannette Lechner-Scott, Ross Copping, Christopher Moeskops and Swee Leong Yap

    Citation: Fluids and Barriers of the CNS 2017 14:18

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