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  1. HIV associated neurocognitive disorders (HAND) are the spectrum of cognitive impairments present in patients infected with human immunodeficiency virus type 1 (HIV-1). The number of patients affected with HAND...

    Authors: Amila Omeragic, Olanre Kayode, Md Tozammel Hoque and Reina Bendayan

    Citation: Fluids and Barriers of the CNS 2020 17:42

    Content type: Review

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  2. Proper neuronal function is directly dependent on the composition, turnover, and amount of interstitial fluid that bathes the cells. Most of the interstitial fluid is likely to be derived from ion and water tr...

    Authors: Daphne M. P. Naessens, Bram F. Coolen, Judith de Vos, Ed VanBavel, Gustav J. Strijkers and Erik N. T. P. Bakker

    Citation: Fluids and Barriers of the CNS 2020 17:41

    Content type: Research

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  3. Measurement of intracranial pressure (ICP) is crucial in the management of many neurological conditions. However, due to the invasiveness, high cost, and required expertise of available ICP monitoring techniqu...

    Authors: Nicolas Canac, Kian Jalaleddini, Samuel G. Thorpe, Corey M. Thibeault and Robert B. Hamilton

    Citation: Fluids and Barriers of the CNS 2020 17:40

    Content type: Review

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  4. Elevated intracranial pressure (ICP) is observed in association with a range of brain disorders. There is limited insight into the regulatory mechanisms of ICP under physiological conditions, and consequently ...

    Authors: Sajedeh Eftekhari, Connar Stanley James Westgate, Katrine Printz Johansen, Signe Rath Bruun and Rigmor H. Jensen

    Citation: Fluids and Barriers of the CNS 2020 17:39

    Content type: Research

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  5. The United States faces a national crisis involving opioid medications, where currently more than 130 people die every day. To combat this epidemic, a better understanding is needed of how opioids penetrate in...

    Authors: Jacquelyn A. Brown, Shannon L. Faley, Yajuan Shi, Kathleen M. Hillgren, Geri A. Sawada, Thomas K. Baker, John P. Wikswo and Ethan S. Lippmann

    Citation: Fluids and Barriers of the CNS 2020 17:38

    Content type: Research

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  6. Pediatric diffuse intrinsic pontine glioma (DIPG) represents one of the most devastating and lethal brain tumors in children with a median survival of 12 months. The high mortality rate can be explained by the...

    Authors: Clémence Deligne, Johan Hachani, Sophie Duban-Deweer, Samuel Meignan, Pierre Leblond, Angel M. Carcaboso, Yasuteru Sano, Fumitaka Shimizu, Takashi Kanda, Fabien Gosselet, Marie-Pierre Dehouck and Caroline Mysiorek

    Citation: Fluids and Barriers of the CNS 2020 17:37

    Content type: Research

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  7. The blood–brain barrier (BBB) plays an important role as a biological barrier by regulating molecular transport between circulating blood and the brain parenchyma. In drug development, the accurate evaluation ...

    Authors: Misaki Yamashita, Hiromasa Aoki, Tadahiro Hashita, Takahiro Iwao and Tamihide Matsunaga

    Citation: Fluids and Barriers of the CNS 2020 17:36

    Content type: Research

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  8. The choroid plexus (CP) forming the blood–cerebrospinal fluid (B-CSF) barrier is among the least studied structures of the central nervous system (CNS) despite its clinical importance. The CP is an epithelio-e...

    Authors: Peter Solár, Alemeh Zamani, Lucie Kubíčková, Petr Dubový and Marek Joukal

    Citation: Fluids and Barriers of the CNS 2020 17:35

    Content type: Review

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  9. Sixty years have passed since neurosurgeon Nils Lundberg presented his thesis about intracranial pressure (ICP) monitoring, which represents a milestone for its clinical introduction. Monitoring of ICP has sin...

    Authors: Karen Brastad Evensen and Per Kristian Eide

    Citation: Fluids and Barriers of the CNS 2020 17:34

    Content type: Review

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  10. Symptomatic or active hydrocephalus in children is linked to an elevation in intracranial pressure (ICP), which is likely to be multifactorial in origin. The CSF outflow resistance, venous sinus resistance and...

    Authors: Grant Alexander Bateman, Swee Leong Yap, Gopinath Musuwadi Subramanian and Alexander Robert Bateman

    Citation: Fluids and Barriers of the CNS 2020 17:33

    Content type: Research

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  11. The most threatening metastases in breast cancer are brain metastases, which correlate with a very poor overall survival, but also a limited quality of life. A key event for the metastatic progression of breas...

    Authors: Carolin J. Curtaz, Constanze Schmitt, Saskia-Laureen Herbert, Jonas Feldheim, Nicolas Schlegel, Fabien Gosselet, Carsten Hagemann, Norbert Roewer, Patrick Meybohm, Achim Wöckel and Malgorzata Burek

    Citation: Fluids and Barriers of the CNS 2020 17:31

    Content type: Research

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  12. Infusion testing is a common procedure to determine whether shunting will be beneficial in patients with normal pressure hydrocephalus. The method has a well-developed theoretical foundation and corresponding ...

    Authors: Vegard Vinje, Anders Eklund, Kent-Andre Mardal, Marie E. Rognes and Karen-Helene Støverud

    Citation: Fluids and Barriers of the CNS 2020 17:29

    Content type: Research

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  13. Iron is crucial for proper functioning of all organs including the brain. Deficiencies and excess of iron are common and contribute to substantial morbidity and mortality. Whereas iron’s involvement in erythro...

    Authors: James R. Connor, Kari Duck, Stephanie Patton, Ian A. Simpson, Lynn Marie Trotti, Richard Allen, Christopher J. Earley and David Rye

    Citation: Fluids and Barriers of the CNS 2020 17:28

    Content type: Short paper

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  14. Several secreted factors have been identified as drivers of cerebral vasculature development and inducers of blood–brain barrier (BBB) differentiation. Vascular endothelial growth factor A (VEGF-A) is central ...

    Authors: Ofri Bar, Sivan Gelb, Kian Atamny, Shira Anzi and Ayal Ben-Zvi

    Citation: Fluids and Barriers of the CNS 2020 17:27

    Content type: Research

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  15. Neuroimmune communication contributes to both baseline and adaptive physiological functions, as well as disease states. The vascular blood–brain barrier (BBB) and associated cells of the neurovascular unit (NV...

    Authors: Michelle A. Erickson, Miranda L. Wilson and William A. Banks

    Citation: Fluids and Barriers of the CNS 2020 17:26

    Content type: Review

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  16. In vitro blood–brain barrier (BBB) models using human induced pluripotent stem (iPS) cell-derived brain microvascular endothelial-like cells (iBMELCs) have been developed to predict the BBB permeability of dru...

    Authors: Hiromasa Aoki, Misaki Yamashita, Tadahiro Hashita, Takahiro Iwao and Tamihide Matsunaga

    Citation: Fluids and Barriers of the CNS 2020 17:25

    Content type: Research

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  17. Post-traumatic hydrocephalus (PTH) is potentially under-diagnosed and under-treated, generating the need for a more efficient diagnostic tool. We aim to report CSF dynamics of patients with post-traumatic vent...

    Authors: Afroditi D. Lalou, Virginia Levrini, Marek Czosnyka, Laurent Gergelé, Matthew Garnett, Angelos Kolias, Peter J. Hutchinson and Zofia Czosnyka

    Citation: Fluids and Barriers of the CNS 2020 17:24

    Content type: Research

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  18. Blood removal from cerebrospinal fluid (CSF) in post-subarachnoid hemorrhage patients may reduce the risk of related secondary brain injury. We formulated a computational fluid dynamics (CFD) model to investig...

    Authors: Mohammadreza Khani, Lucas R. Sass, M. Keith Sharp, Aaron R. McCabe, Laura M. Zitella Verbick, Shivanand P. Lad and Bryn A. Martin

    Citation: Fluids and Barriers of the CNS 2020 17:23

    Content type: Research

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  19. The blood–brain barrier (BBB) is a fundamental component of the central nervous system. Its functional and structural integrity is vital in maintaining the homeostasis of the brain microenvironment. On the oth...

    Authors: Aditya Bhalerao, Farzane Sivandzade, Sabrina Rahman Archie, Ekram Ahmed Chowdhury, Behnam Noorani and Luca Cucullo

    Citation: Fluids and Barriers of the CNS 2020 17:22

    Content type: Review

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  20. The blood–brain barrier (BBB) maintains homeostasis of the brain environment by tightly regulating the entry of substances from systemic circulation. A breach in the BBB results in increased permeability to po...

    Authors: Kyeong-A Kim, Donghyun Kim, Jeong-Hyeon Kim, Young-Jun Shin, Eun-Sun Kim, Muhammad Akram, Eun-Hye Kim, Arshad Majid, Seung-Hoon Baek and Ok-Nam Bae

    Citation: Fluids and Barriers of the CNS 2020 17:21

    Content type: Research

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  21. The blood–brain barrier (BBB) is altered in several diseases of the central nervous system. For example, the breakdown of the BBB during cerebral ischemia in stroke or traumatic brain injury is a hallmark of t...

    Authors: Anna Gerhartl, Nadja Pracser, Alexandra Vladetic, Sabrina Hendrikx, Heinz-Peter Friedl and Winfried Neuhaus

    Citation: Fluids and Barriers of the CNS 2020 17:19

    Content type: Research

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  22. After ventriculoperitoneal shunt surgery for idiopathic normal pressure hydrocephalus (iNPH) with adjustable gravitational valves, a certain proportion of patients develop secondary clinical worsening after in...

    Authors: Pawel Gutowski, Sergej Rot, Michael Fritsch, Ullrich Meier, Leonie Gölz and Johannes Lemcke

    Citation: Fluids and Barriers of the CNS 2020 17:18

    Content type: Research

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  23. Syringomyelia is a serious complication of spinal cord trauma, occurring in approximately 28% of spinal cord injuries. Treatment options are limited and often produce unsatisfactory results. Post-traumatic syr...

    Authors: Joel Berliner, Sarah Hemley, Elmira Najafi, Lynne Bilston, Marcus Stoodley and Magdalena Lam

    Citation: Fluids and Barriers of the CNS 2020 17:11

    Content type: Research

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  24. Hydrocephalus is a common and major complication that affects outcome after intraventricular hemorrhage (IVH). While aging impacts the occurrence of hydrocephalus in patients with IVH this and the underlying m...

    Authors: Yingfeng Wan, Feng Gao, Fenghui Ye, Weiming Yang, Ya Hua, Richard F. Keep and Guohua Xi

    Citation: Fluids and Barriers of the CNS 2020 17:8

    Content type: Research

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  25. Elevation of the chemokine CXCL13 in CSF frequently occurs during active and acute CNS inflammatory processes and presumably is associated with B cell-related immune activation. Elevation levels, however, vary...

    Authors: Georg Pilz, Irma Sakic, Peter Wipfler, Jörg Kraus, Elisabeth Haschke-Becher, Wolfgang Hitzl, Eugen Trinka and Andrea Harrer

    Citation: Fluids and Barriers of the CNS 2020 17:7

    Content type: Research

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  26. Idiopathic normal pressure hydrocephalus (iNPH) is a neurodegenerative disease with an unknown etiology. Disturbed corticospinal inhibition of the motor cortex has been reported in iNPH and can be evaluated in...

    Authors: Jani Sirkka, Laura Säisänen, Petro Julkunen, Mervi Könönen, Elisa Kallioniemi, Ville Leinonen and Nils Danner

    Citation: Fluids and Barriers of the CNS 2020 17:6

    Content type: Research

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  27. Cerebrospinal fluid (CSF) is mainly produced by the choroid plexus (CP) located in brain ventricles. Although derived from blood plasma, it is nearly protein-free (~ 250-fold less) and contains about 2–20-fold...

    Authors: Elena Dolgodilina, Simone M. Camargo, Eva Roth, Brigitte Herzog, Virginia Nunes, Manuel Palacín and Francois Verrey

    Citation: Fluids and Barriers of the CNS 2020 17:17

    Content type: Research

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  28. The endothelial cell–cell junctions of the blood–brain barrier (BBB) play a pivotal role in the barrier’s function. Altered cell–cell junctions can lead to barrier dysfunction and have been implicated in sever...

    Authors: Kelsey M. Gray, Jae W. Jung, Collin T. Inglut, Huang-Chiao Huang and Kimberly M. Stroka

    Citation: Fluids and Barriers of the CNS 2020 17:16

    Content type: Research

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  29. The classical view of cerebrospinal fluid (CSF) production posits the choroid plexus as its major source. Although previous studies indicate that part of CSF production occurs in the subarachnoid space (SAS), ...

    Authors: Qianliang Li, Nadia N. Aalling, Benjamin Förstera, Ali Ertürk, Maiken Nedergaard, Kjeld Møllgård and Anna L. R. Xavier

    Citation: Fluids and Barriers of the CNS 2020 17:15

    Content type: Research

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  30. Idiopathic intracranial hypertension (IIH) is a neurological disorder characterised by raised cerebrospinal fluid (CSF) pressure in the absence of any intracranial pathology. IIH mainly affects women with obes...

    Authors: Zerin Alimajstorovic, Ester Pascual-Baixauli, Cheryl A. Hawkes, Basil Sharrack, A. Jane Loughlin, Ignacio A. Romero and Jane E. Preston

    Citation: Fluids and Barriers of the CNS 2020 17:10

    Content type: Research

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  31. Excitotoxicity is a central pathological pathway in many neurological diseases with blood–brain barrier (BBB) dysfunction. Kainate, an exogenous excitotoxin, induces epilepsy and BBB damage in animal models, b...

    Authors: Lilla Barna, Fruzsina R. Walter, András Harazin, Alexandra Bocsik, András Kincses, Vilmos Tubak, Katalin Jósvay, Ágnes Zvara, Patricia Campos-Bedolla and Mária A. Deli

    Citation: Fluids and Barriers of the CNS 2020 17:5

    Content type: Research

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  32. The cerebrospinal fluid (CSF)/serum quotient of albumin (QAlb) is the most used biomarker for the evaluation of blood–cerebrospinal fluid barrier (B-CSF-B) permeability. For years QAlb was considered only as a...

    Authors: Massimiliano Castellazzi, Andrea Morotti, Carmine Tamborino, Francesca Alessi, Silvy Pilotto, Eleonora Baldi, Luisa M. Caniatti, Alessandro Trentini, Ilaria Casetta, Enrico Granieri, Maura Pugliatti, Enrico Fainardi and Tiziana Bellini

    Citation: Fluids and Barriers of the CNS 2020 17:14

    Content type: Research

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  33. Choroid plexus (CP) is an important tissue not only to produce cerebrospinal fluid (CSF) but also to regulate substances that are secreted into or absorbed from CSF through blood–cerebrospinal fluid barrier (B...

    Authors: Fumiko Obata and Keishi Narita

    Citation: Fluids and Barriers of the CNS 2020 17:13

    Content type: Research

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  34. The brain barriers establish compartments in the central nervous system (CNS) that significantly differ in their communication with the peripheral immune system. In this function they strictly control T-cell e...

    Authors: Hideaki Nishihara, Sasha Soldati, Adrien Mossu, Maria Rosito, Henriette Rudolph, William A. Muller, Daniela Latorre, Federica Sallusto, Mireia Sospedra, Roland Martin, Hiroshi Ishikawa, Tobias Tenenbaum, Horst Schroten, Fabien Gosselet and Britta Engelhardt

    Citation: Fluids and Barriers of the CNS 2020 17:3

    Content type: Research

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  35. Several small cross-sectional studies have investigated cerebrospinal fluid (CSF) flow dynamics in multiple sclerosis (MS) patients and have reported mixed results. Currently, there are no longitudinal studies...

    Authors: Dejan Jakimovski, Robert Zivadinov, Bianca Weinstock-Guttman, Niels Bergsland, Michael G. Dwyer and Marcella Maria Lagana

    Citation: Fluids and Barriers of the CNS 2020 17:9

    Content type: Research

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  36. Developing novel therapeutic agents to treat amyotrophic lateral sclerosis (ALS) has been difficult due to multifactorial pathophysiologic processes at work. Intrathecal drug administration shows promise due t...

    Authors: Lucas R. Sass, Mohammadreza Khani, Jacob Romm, Marianne Schmid Daners, Kyle McCain, Tavara Freeman, Gregory T. Carter, Douglas L. Weeks, Brian Petersen, Jason Aldred, Dena Wingett and Bryn A. Martin

    Citation: Fluids and Barriers of the CNS 2020 17:4

    Content type: Research

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  37. Both aging and changes in blood flow velocity between the extracranial (intraspinal) and intracranial regions of cerebral vessels have an impact on brain hydro-hemodynamics. Arterial and venous cerebral blood ...

    Authors: Armelle Lokossou, Serge Metanbou, Catherine Gondry-Jouet and Olivier Balédent

    Citation: Fluids and Barriers of the CNS 2020 17:1

    Content type: Research

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  38. Genetic disruption of slc4a10, which encodes the sodium-dependent chloride/bicarbonate exchanger Ncbe, leads to a major decrease in Na+-dependent HCO3 import into choroid plexus epithelial cells in mice and to a...

    Authors: Inga Baasch Christensen, Qi Wu, Anders Solitander Bohlbro, Marianne Gerberg Skals, Helle Hasager Damkier, Christian Andreas Hübner, Robert Andrew Fenton and Jeppe Praetorius

    Citation: Fluids and Barriers of the CNS 2020 17:2

    Content type: Research

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  39. Communicating hydrocephalus is a disease where the cerebral ventricles are enlarged. It is characterized by the absence of detectable cerebrospinal fluid (CSF) outflow obstructions and often with increased CSF...

    Authors: P. Holmlund, S. Qvarlander, J. Malm and A. Eklund

    Citation: Fluids and Barriers of the CNS 2019 16:40

    Content type: Research

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  40. This article highlights the scientific achievements, professional career, and personal interactions of Malcolm B. Segal who passed away in July this year. Born in 1937 in Goodmayes, Essex, UK, Segal rose to th...

    Authors: Adam Chodobski, Jean-François Ghersi-Egea, Jane Preston-Kennedy, Zoran Redzic, Nathalie Strazielle, Joanna Szmydynger-Chodobska and Robert G. Thorne

    Citation: Fluids and Barriers of the CNS 2019 16:41

    Content type: Letter to the Editor

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  41. A growing body of evidence suggests that the accumulation of amyloid-β and tau (HPτ) in the brain of patients with the dementia subtype idiopathic normal pressure hydrocephalus (iNPH) is associated with delaye...

    Authors: Md Mahdi Hasan-Olive, Rune Enger, Hans-Arne Hansson, Erlend A. Nagelhus and Per Kristian Eide

    Citation: Fluids and Barriers of the CNS 2019 16:39

    Content type: Research

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  42. Research into amisulpride use in Alzheimer’s disease (AD) implicates blood–brain barrier (BBB) dysfunction in antipsychotic sensitivity. Research into BBB transporters has been mainly directed towards the ABC ...

    Authors: Gayathri Nair Sekhar, Alice L. Fleckney, Sevda Tomova Boyanova, Huzefa Rupawala, Rachel Lo, Hao Wang, Doaa B. Farag, Khondaker Miraz Rahman, Martin Broadstock, Suzanne Reeves and Sarah Ann Thomas

    Citation: Fluids and Barriers of the CNS 2019 16:38

    Content type: Research

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  43. Lumbar puncture (LP) is a common way of collecting cerebrospinal fluid (CSF) both in the clinic and in research. In this extension of a study on the relationship between sleep deprivation and CSF biomarkers fo...

    Authors: Martin Olsson, Johan Ärlig, Jan Hedner, Kaj Blennow and Henrik Zetterberg

    Citation: Fluids and Barriers of the CNS 2019 16:37

    Content type: Short paper

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  44. Elevated intracranial pressure (ICP) is observed in association with a range of brain disorders. One of these challenging disorders is idiopathic intracranial hypertension (IIH), characterized by raised ICP of...

    Authors: Sajedeh Eftekhari, Connar Stanley James Westgate, Maria Schmidt Uldall and Rigmor Hoejland Jensen

    Citation: Fluids and Barriers of the CNS 2019 16:35

    Content type: Review

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  45. Cerebrospinal fluid (CSF) metabolomic investigations are a powerful tool for studying neurometabolic diseases. We aimed to assess the effect of CSF contamination with blood on the concentrations of selected bi...

    Authors: Marta Batllori, Mercedes Casado, Cristina Sierra, Maria del Carmen Salgado, Laura Marti-Sanchez, Joan Maynou, Guerau Fernandez, Angels Garcia-Cazorla, Aida Ormazabal, Marta Molero-Luis and Rafael Artuch

    Citation: Fluids and Barriers of the CNS 2019 16:34

    Content type: Research

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