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  1. Repetitive transient intracranial pressure waveform elevations up to 50 mmHg (ICP B-waves) are often used to define pathological conditions and determine indications for ICP-reducing treatment. We recently sho...

    Authors: Casper Schwartz Riedel, Isabel Martinez-Tejada, Morten Andresen, Jens E. Wilhjelm, Poul Jennum and Marianne Juhler
    Citation: Fluids and Barriers of the CNS 2023 20:69
    Content type: Research Published on:

  3. Pharmacological treatment of CNS diseases is limited due to the presence of the blood-brain barrier (BBB). Recent years showed significant advancement in the field of CNS drug delivery enablers, with technolog...

    Authors: Itzik Cooper, David Last, Orly Ravid, Daniel Rand, Erez Matsree, Liora Omesi, Chen Shemesh, Meir Liberman, Leor Zach, Orit Furman, Dianne Daniels, Sigal Liraz-Zaltsman, Yael Mardor and Shirley Sharabi
    Citation: Fluids and Barriers of the CNS 2023 20:67
    Content type: Research Published on:

  4. Blood–brain barrier (BBB) dysfunction is supposed to be an early event in the development of Alzheimer’s disease (AD). This study aimed to investigate the relationship between BBB alterations and AD progressio...

    Authors: Shingo Ito, Ryotaro Yagi, Seiryo Ogata, Takeshi Masuda, Takashi Saito, Takaomi Saido and Sumio Ohtsuki
    Citation: Fluids and Barriers of the CNS 2023 20:66
    Content type: Research Published on:

  5. Since arterial flow is the leading actor in neuro-fluids flow dynamics, it might be interesting to assess whether it is meaningful to study the arterial flow waveform in more detail and whether this provides n...

    Authors: Kimi Piedad Owashi, Cyrille Capel and Olivier Balédent
    Citation: Fluids and Barriers of the CNS 2023 20:65
    Content type: Research Published on:

  6. The blood brain barrier limits entry of macromolecular diagnostic and therapeutic cargos. Blood brain barrier transcytosis via receptor mediated transport systems, such as the transferrin receptor, can be used...

    Authors: Thomas J. Esparza, Shiran Su, Caroline M. Francescutti, Elvira Rodionova, Joong Hee Kim and David L. Brody
    Citation: Fluids and Barriers of the CNS 2023 20:64
    Content type: Research Published on:

  7. The literature regarding the global cerebral blood flow (CBF) in idiopathic intracranial hypertension (IIH) is divergent leading to skepticism about the significance of blood flow to the disease’s underlying p...

    Authors: Grant A Bateman
    Citation: Fluids and Barriers of the CNS 2023 20:63
    Content type: Review Published on:

  8. Whether you are reading, running or sleeping, your brain and its fluid environment continuously interacts to distribute nutrients and clear metabolic waste. Yet, the precise mechanisms for solute transport wit...

    Authors: Vegard Vinje, Bastian Zapf, Geir Ringstad, Per Kristian Eide, Marie E. Rognes and Kent-Andre Mardal
    Citation: Fluids and Barriers of the CNS 2023 20:62
    Content type: Research Published on:

  9. Hydrocephalus is a pathological accumulation of cerebrospinal fluid (CSF), leading to ventriculomegaly. Hydrocephalus may be primary or secondary to traumatic brain injury, infection, or intracranial hemorrhag...

    Authors: Alexandra Hochstetler, Hillary Smith, Makenna Reed, Louise Hulme, Paul Territo, Amanda Bedwell, Scott Persohn, Nicola Perrotti, Lucia D’Antona, Francesca Musumeci, Silvia Schenone and Bonnie L. Blazer-Yost
    Citation: Fluids and Barriers of the CNS 2023 20:61
    Content type: Research Published on:

  10. Mounting evidence suggests that the blood-brain barrier (BBB) plays an important role in the regulation of brain iron homeostasis in normal brain development, but these imaging profiles remain to be elucidated...

    Authors: Yuto Uchida, Hirohito Kan, Gen Furukawa, Kengo Onda, Keita Sakurai, Koji Takada, Noriyuki Matsukawa and Kenichi Oishi
    Citation: Fluids and Barriers of the CNS 2023 20:60
    Content type: Research Published on:

  11. Insulin-like growth factor-1 (IGF-1) is essential for normal brain development and regulates essential processes of vascular maturation and stabilization. Importantly, preterm birth is associated with reduced ...

    Authors: Niklas Ortenlöf, Suvi Vallius, Helena Karlsson, Claes Ekström, Amanda Kristiansson, Bo Holmqvist, Olga Göransson, Magdaléna Vaváková, Martin Rydén, Galen Carey, Norman Barton, David Ley and Magnus Gram
    Citation: Fluids and Barriers of the CNS 2023 20:59
    Content type: Research Published on:

  12. Optimal shunt-based hydrocephalus treatments are heavily influenced by dynamic pressure behaviors between proximal and distal ends of shunt catheters. Posture-dependent craniospinal, arterial, venous, and abdo...

    Authors: Anthony Podgoršak, Nina Eva Trimmel, Fabian Flürenbrock, Markus Florian Oertel, Margarete Arras, Miriam Weisskopf and Marianne Schmid Daners
    Citation: Fluids and Barriers of the CNS 2023 20:58
    Content type: Research Published on:

  14. Flow of cerebrospinal fluid (CSF) through brain perivascular spaces (PVSs) is essential for the clearance of interstitial metabolic waste products whose accumulation and aggregation is a key mechanism of patho...

    Authors: Nikola Raicevic, Jarod M. Forer, Antonio Ladrón-de-Guevara, Ting Du, Maiken Nedergaard, Douglas H. Kelley and Kimberly Boster
    Citation: Fluids and Barriers of the CNS 2023 20:56
    Content type: Research Published on:

  15. Authors: Ivana Lazarevic, Sasha Soldati, Josephine A. Mapunda, Henriette Rudolph, Maria Rosito, Alex Cardoso de Oliveira, Gaby Enzmann, Hideaki Nishihara, Hiroshi Ishikawa, Tobias Tenenbaum, Horst Schroten and Britta Engelhardt
    Citation: Fluids and Barriers of the CNS 2023 20:55
    Content type: Correction Published on:

    The original article was published in Fluids and Barriers of the CNS 2023 20:39

  16. Neurofilament light chain protein (NFL), a marker of neuronal axonal degeneration, is increased in cerebrospinal fluid (CSF) of patients with idiopathic normal pressure hydrocephalus (iNPH). Assays for analysi...

    Authors: A. Jeppsson, Å. Sandelius, A. Zettergren, S. Kern, I. Skoog, K. Blennow, H. Zetterberg, C. Wikkelsø, P. Hellström and M. Tullberg
    Citation: Fluids and Barriers of the CNS 2023 20:54
    Content type: Research Published on:

  17. Hydrocephalus constitutes a complex neurological condition of heterogeneous origin characterized by excessive cerebrospinal fluid (CSF) accumulation within the brain ventricles. The condition may dangerously e...

    Authors: Sara Diana Lolansen, Dagne Barbuskaite, Fenghui Ye, Jianming Xiang, Richard F. Keep and Nanna MacAulay
    Citation: Fluids and Barriers of the CNS 2023 20:53
    Content type: Research Published on:

  18. Maintaining a tight blood–brain barrier (BBB) is an important prerequisite for the preservation of neurological health, though current evidence suggests it declines with age. While extracellular matrix-integri...

    Authors: Sebok K. Halder, Violaine D. Delorme-Walker and Richard Milner
    Citation: Fluids and Barriers of the CNS 2023 20:52
    Content type: Research Published on:

  19. CNS vasculature differs from vascular networks of peripheral organs by its ability to tightly control selective material exchange across capillary barriers. Capillary permeability is mostly defined by unique c...

    Authors: Batia Bell, Shira Anzi, Esther Sasson and Ayal Ben-Zvi
    Citation: Fluids and Barriers of the CNS 2023 20:51
    Content type: Research Published on:

  20. The functions and protein expressions of the blood–brain barrier are changed throughout brain development following birth. This study aimed to develop a method to isolate brain capillaries from a single frozen...

    Authors: Yudai Hamada, Seiryo Ogata, Takeshi Masuda, Shingo Ito and Sumio Ohtsuki
    Citation: Fluids and Barriers of the CNS 2023 20:50
    Content type: Research Published on:

  21. It is crucial to maintain the intracranial pressure (ICP) within the physiological range to ensure proper brain function. The ICP may fluctuate during the light-dark phase cycle, complicating diagnosis and tre...

    Authors: Annette Buur Steffensen, Beatriche Louise Edelbo, Dagne Barbuskaite, Søren Norge Andreassen, Markus Harboe Olsen, Kirsten Møller and Nanna MacAulay
    Citation: Fluids and Barriers of the CNS 2023 20:49
    Content type: Research Published on:

  23. Reduced folate carrier 1 (RFC1; SLC19a1) is the main responsible transporter for the B9 family of vitamins named folates, which are essential for normal tissue growth and development. While folate deficiency r...

    Authors: Gokce Gurler, Nevin Belder, Mustafa Caglar Beker, Melike Sever-Bahcekapili, Gokhan Uruk, Ertugrul Kilic and Muge Yemisci
    Citation: Fluids and Barriers of the CNS 2023 20:47
    Content type: Research Published on:

  24. Focused ultrasound (FUS)-mediated blood–brain barrier (BBB) opening is under investigation as a therapeutic modality for neurodegeneration, yet its effects in humans are incompletely understood. Here, we asses...

    Authors: Rashi I. Mehta, Jeffrey S. Carpenter, Rupal I. Mehta, Marc W. Haut, Peng Wang, Manish Ranjan, Umer Najib, Pierre-François D’Haese and Ali R. Rezai
    Citation: Fluids and Barriers of the CNS 2023 20:46
    Content type: Research Published on:

  25. Regulation of the volume and electrolyte composition of the cerebrospinal fluid (CSF) is vital for brain development and function. The Na-K-Cl co-transporter NKCC1 in the choroid plexus (ChP) plays key roles i...

    Authors: Ryann M. Fame, Huixin Xu, Aja Pragana and Maria Lehtinen
    Citation: Fluids and Barriers of the CNS 2023 20:45
    Content type: Brief Report Published on:

  26. Idiopathic intracranial hypertension (IIH) is a condition characterized by increased intracranial pressure (ICP), impaired vision, and headache. Most cases of IIH occur in obese women of childbearing age, thou...

    Authors: Jonathan H. Wardman, Mette N. Jensen, Søren N. Andreassen, Bjarne Styrishave, Jens E. Wilhjelm, Alexandra J. Sinclair and Nanna MacAulay
    Citation: Fluids and Barriers of the CNS 2023 20:44
    Content type: Research Published on:

  27. Despite recent attention, pathways and mechanisms of fluid transposition in the brain are still a matter of intense discussion and driving forces underlying waste clearance in the brain remain elusive. Consens...

    Authors: Martin Segeroth, Lydia Wachsmuth, Mathias Gagel, Franziska Albers, Andreas Hess and Cornelius Faber
    Citation: Fluids and Barriers of the CNS 2023 20:43
    Content type: Research Published on:

  28. Neonatal hydrocephalus is a congenital abnormality resulting in an inflammatory response and microglial cell activation both clinically and in animal models. Previously, we reported a mutation in a motile cili...

    Authors: Farrah N. Brown, Eri Iwasawa, Crystal Shula, Elizabeth M. Fugate, Diana M. Lindquist, Francesco T. Mangano and June Goto
    Citation: Fluids and Barriers of the CNS 2023 20:42
    Content type: Research Published on:

  30. Idiopathic Normal pressure hydrocephalus (iNPH) is a form of adult hydrocephalus that is clinically characterized by progressive gait impairment, cognitive dysfunction, and urinary incontinence. The current st...

    Authors: Sophia Weiner, Antti Junkkari, Mathias Sauer, Antti Luikku, Tuomas Rauramaa, Tarja Kokkola, Sanna-Kaisa Herukka, Kaj Blennow, Henrik Zetterberg, Ville Leinonen and Johan Gobom
    Citation: Fluids and Barriers of the CNS 2023 20:40
    Content type: Research Published on:

  31. The choroid plexus (ChP) has been suggested as an alternative central nervous system (CNS) entry site for CCR6+ Th17 cells during the initiation of experimental autoimmune encephalomyelitis (EAE), an animal model...

    Authors: Ivana Lazarevic, Sasha Soldati, Josephine A. Mapunda, Henriette Rudolph, Maria Rosito, Alex Cardoso de Oliveira, Gaby Enzmann, Hideaki Nishihara, Hiroshi Ishikawa, Tobias Tenenbaum, Horst Schroten and Britta Engelhardt
    Citation: Fluids and Barriers of the CNS 2023 20:39
    Content type: Research Published on:

    The Correction to this article has been published in Fluids and Barriers of the CNS 2023 20:55

  33. The clearance pathways of brain waste products in humans are still under debate in part due to the lack of noninvasive imaging techniques for meningeal lymphatic vessels (mLVs). In this study, we propose a new...

    Authors: Jun-Hee Kim, Roh-Eul Yoo, Seung Hong Choi and Sung-Hong Park
    Citation: Fluids and Barriers of the CNS 2023 20:37
    Content type: Research Published on:

  34. Blood brain barrier (BBB) models in vitro are an important tool to aid in the pre-clinical evaluation and selection of BBB-crossing therapeutics. Stem cell derived BBB models have recently demonstrated a subst...

    Authors: Anna Jezierski, Jez Huang, Arsalan S. Haqqani, Julie Haukenfrers, Ziying Liu, Ewa Baumann, Caroline Sodja, Claudie Charlebois, Christie E. Delaney, Alexandra T. Star, Qing Liu and Danica B. Stanimirovic
    Citation: Fluids and Barriers of the CNS 2023 20:36
    Content type: Research Published on:

  35. Glucocorticoids (GCs) are widely prescribed for a variety of inflammatory diseases, but they are also used to treat raised intracranial pressure (ICP) caused by trauma or oedema. However, it is unclear if GCs ...

    Authors: Connar Stanley James Westgate, Ida Marchen Egerod Israelsen, Christina Kamp-Jensen, Rigmor Højland Jensen and Sajedeh Eftekhari
    Citation: Fluids and Barriers of the CNS 2023 20:35
    Content type: Research Published on:

  37. The frequencies of morbidity and impairment associated with spontaneous intracerebral haemorrhage (ICH) are comparatively high. Blood-brain barrier (BBB) integrity was compromised due to subsequent brain injur...

    Authors: Ling Gao, Li Peng, Prativa Sherchan, Hong Tang, Yu Liu, Jie Xiao, Hui Shi, Yujie Luo, Jiping Tang, John H. Zhang and Ying Xia
    Citation: Fluids and Barriers of the CNS 2023 20:33
    Content type: Research Published on:

  38. Lead (Pb) is a known environmental risk factor in the etiology of Alzheimer’s disease (AD). The existing reports suggest that Pb exposure increases beta-amyloid (Aβ) levels in brain tissues and cerebrospinal f...

    Authors: Luke L. Liu, Xiaoli Shen, Huiying Gu, Gang Zhao, Yansheng Du and Wei Zheng
    Citation: Fluids and Barriers of the CNS 2023 20:32
    Content type: Research Published on:

  39. Blue light is part of the natural light spectrum that emits high energy. Currently, people are frequently exposed to blue light from 3C devices, resulting in a growing incidence of retinopathy. The retinal vas...

    Authors: Yen-Ju Chan, George Hsiao, Wang-Nok Wan, Tsung-Min Yang, Chi-Hao Tsai, Jaw-Jou Kang, Yu-Cheng Lee, Te-Chao Fang, Yu-Wen Cheng and Ching-Hao Li
    Citation: Fluids and Barriers of the CNS 2023 20:31
    Content type: Research Published on:

  40. This aim of this editorial is to highlight progress made in brain barrier and brain fluid research in 2022. It covers studies on the blood-brain, blood-retina and blood-CSF barriers (choroid plexus and meninge...

    Authors: Richard F. Keep, Hazel C. Jones, Mark G. Hamilton and Lester R. Drewes
    Citation: Fluids and Barriers of the CNS 2023 20:30
    Content type: Editorial Published on:

  42. Insulin transport across the blood-brain barrier (BBB) is a highly regulated, saturable process, known to be affected by many peripheral substrates including insulin itself and triglycerides. This is in contra...

    Authors: Van Nguyen, Peter Thomas, Sarah Pemberton, Alice Babin, Cassidy Noonan, Riley Weaver, William A. Banks and Elizabeth M. Rhea
    Citation: Fluids and Barriers of the CNS 2023 20:28
    Content type: Research Published on:

  44. Recent data indicates that cerebrospinal fluid (CSF) dynamics are disturbed after stroke. Our lab has previously shown that intracranial pressure rises dramatically 24 h after experimental stroke and that this...

    Authors: K. E. Warren, K. G. Coupland, R. J. Hood, L. Kang, F. R. Walker and N. J. Spratt
    Citation: Fluids and Barriers of the CNS 2023 20:27
    Content type: Research Published on:

  45. Blood–brain barrier (BBB) dysfunction occurs in many brain diseases, and there is increasing evidence to suggest that it is an early process in dementia which may be exacerbated by peripheral infection. Filter...

    Authors: Yolanda Ohene, William J. Harris, Elizabeth Powell, Nina W. Wycech, Katherine F. Smethers, Samo Lasič, Kieron South, Graham Coutts, Andrew Sharp, Catherine B. Lawrence, Hervé Boutin, Geoff J. M. Parker, Laura M. Parkes and Ben R. Dickie
    Citation: Fluids and Barriers of the CNS 2023 20:25
    Content type: Research Published on:

  46. Oligodendrocyte lineage cells interact with the vasculature in the gray matter. Physical and functional interactions between blood vessels and oligodendrocyte precursor cells play an essential role in both the...

    Authors: Justine S. C. Palhol, Maddalena Balia, Fernando Sánchez-Román Terán, Mélody Labarchède, Etienne Gontier and Arne Battefeld
    Citation: Fluids and Barriers of the CNS 2023 20:24
    Content type: Research Published on:

  47. Despite greatly renewed interest concerning meningeal lymphatic function over recent years, the lymphatic structures of human dura mater have been less characterized. The available information derives exclusiv...

    Authors: César Luis Vera Quesada, Shreyas Balachandra Rao, Reidun Torp and Per Kristian Eide
    Citation: Fluids and Barriers of the CNS 2023 20:23
    Content type: Research Published on:

  48. The CLDN5 gene encodes claudin-5 (CLDN-5) that is expressed in endothelial cells and forms tight junctions which limit the passive diffusions of ions and solutes. The blood–brain barrier (BBB), composed of brain ...

    Authors: Yosuke Hashimoto, Chris Greene, Arnold Munnich and Matthew Campbell
    Citation: Fluids and Barriers of the CNS 2023 20:22
    Content type: Review Published on:

  49. The meninges, formed by dura, arachnoid and pia mater, cover the central nervous system and provide important barrier functions. Located between arachnoid and pia mater, the cerebrospinal fluid (CSF)-filled su...

    Authors: Diego Rossinelli, Hanspeter Esriel Killer, Peter Meyer, Graham Knott, Gilles Fourestey, Vartan Kurtcuoglu, Corina Kohler, Philipp Gruber, Luca Remonda, Albert Neutzner and Jatta Berberat
    Citation: Fluids and Barriers of the CNS 2023 20:21
    Content type: Research Published on:

  50. Astrocyte endfoot processes are believed to cover all micro-vessels in the brain cortex and may play a significant role in fluid and substance transport into and out of the brain parenchyma. Detailed fluid mec...

    Authors: Timo Koch, Vegard Vinje and Kent-André Mardal
    Citation: Fluids and Barriers of the CNS 2023 20:20
    Content type: Research Published on:

    The Correction to this article has been published in Fluids and Barriers of the CNS 2023 20:57

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  • ISSN: 2045-8118 (electronic)

Fluids and Barriers of the CNS

ISSN: 2045-8118