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  1. Developing novel therapeutic agents to treat amyotrophic lateral sclerosis (ALS) has been difficult due to multifactorial pathophysiologic processes at work. Intrathecal drug administration shows promise due t...

    Authors: Lucas R. Sass, Mohammadreza Khani, Jacob Romm, Marianne Schmid Daners, Kyle McCain, Tavara Freeman, Gregory T. Carter, Douglas L. Weeks, Brian Petersen, Jason Aldred, Dena Wingett and Bryn A. Martin

    Citation: Fluids and Barriers of the CNS 2020 17:4

    Content type: Research

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  2. Both aging and changes in blood flow velocity between the extracranial (intraspinal) and intracranial regions of cerebral vessels have an impact on brain hydro-hemodynamics. Arterial and venous cerebral blood ...

    Authors: Armelle Lokossou, Serge Metanbou, Catherine Gondry-Jouet and Olivier Balédent

    Citation: Fluids and Barriers of the CNS 2020 17:1

    Content type: Research

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  3. Genetic disruption of slc4a10, which encodes the sodium-dependent chloride/bicarbonate exchanger Ncbe, leads to a major decrease in Na+-dependent HCO3− import into choroid plexus epithelial cells in mice and to a...

    Authors: Inga Baasch Christensen, Qi Wu, Anders Solitander Bohlbro, Marianne Gerberg Skals, Helle Hasager Damkier, Christian Andreas Hübner, Robert Andrew Fenton and Jeppe Praetorius

    Citation: Fluids and Barriers of the CNS 2020 17:2

    Content type: Research

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  4. Communicating hydrocephalus is a disease where the cerebral ventricles are enlarged. It is characterized by the absence of detectable cerebrospinal fluid (CSF) outflow obstructions and often with increased CSF...

    Authors: P. Holmlund, S. Qvarlander, J. Malm and A. Eklund

    Citation: Fluids and Barriers of the CNS 2019 16:40

    Content type: Research

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  5. This article highlights the scientific achievements, professional career, and personal interactions of Malcolm B. Segal who passed away in July this year. Born in 1937 in Goodmayes, Essex, UK, Segal rose to th...

    Authors: Adam Chodobski, Jean-François Ghersi-Egea, Jane Preston-Kennedy, Zoran Redzic, Nathalie Strazielle, Joanna Szmydynger-Chodobska and Robert G. Thorne

    Citation: Fluids and Barriers of the CNS 2019 16:41

    Content type: Letter to the Editor

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  6. A growing body of evidence suggests that the accumulation of amyloid-β and tau (HPτ) in the brain of patients with the dementia subtype idiopathic normal pressure hydrocephalus (iNPH) is associated with delaye...

    Authors: Md Mahdi Hasan-Olive, Rune Enger, Hans-Arne Hansson, Erlend A. Nagelhus and Per Kristian Eide

    Citation: Fluids and Barriers of the CNS 2019 16:39

    Content type: Research

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  7. Research into amisulpride use in Alzheimer’s disease (AD) implicates blood–brain barrier (BBB) dysfunction in antipsychotic sensitivity. Research into BBB transporters has been mainly directed towards the ABC ...

    Authors: Gayathri Nair Sekhar, Alice L. Fleckney, Sevda Tomova Boyanova, Huzefa Rupawala, Rachel Lo, Hao Wang, Doaa B. Farag, Khondaker Miraz Rahman, Martin Broadstock, Suzanne Reeves and Sarah Ann Thomas

    Citation: Fluids and Barriers of the CNS 2019 16:38

    Content type: Research

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  8. Lumbar puncture (LP) is a common way of collecting cerebrospinal fluid (CSF) both in the clinic and in research. In this extension of a study on the relationship between sleep deprivation and CSF biomarkers fo...

    Authors: Martin Olsson, Johan Ärlig, Jan Hedner, Kaj Blennow and Henrik Zetterberg

    Citation: Fluids and Barriers of the CNS 2019 16:37

    Content type: Short paper

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  10. Elevated intracranial pressure (ICP) is observed in association with a range of brain disorders. One of these challenging disorders is idiopathic intracranial hypertension (IIH), characterized by raised ICP of...

    Authors: Sajedeh Eftekhari, Connar Stanley James Westgate, Maria Schmidt Uldall and Rigmor Hoejland Jensen

    Citation: Fluids and Barriers of the CNS 2019 16:35

    Content type: Review

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  11. Cerebrospinal fluid (CSF) metabolomic investigations are a powerful tool for studying neurometabolic diseases. We aimed to assess the effect of CSF contamination with blood on the concentrations of selected bi...

    Authors: Marta Batllori, Mercedes Casado, Cristina Sierra, Maria del Carmen Salgado, Laura Marti-Sanchez, Joan Maynou, Guerau Fernandez, Angels Garcia-Cazorla, Aida Ormazabal, Marta Molero-Luis and Rafael Artuch

    Citation: Fluids and Barriers of the CNS 2019 16:34

    Content type: Research

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  12. Although B waves were introduced as a concept in the analysis of intracranial pressure (ICP) recordings nearly 60 years ago, there is still a lack consensus on precise definitions, terminology, amplitude, freq...

    Authors: Isabel Martinez-Tejada, Alexander Arum, Jens E. Wilhjelm, Marianne Juhler and Morten Andresen

    Citation: Fluids and Barriers of the CNS 2019 16:33

    Content type: Review

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  13. Influx and clearance of substances in the brain parenchyma occur by a combination of diffusion and convection, but the relative importance of these mechanisms is unclear. Accurate modeling of tracer distributi...

    Authors: Matteo Croci, Vegard Vinje and Marie E. Rognes

    Citation: Fluids and Barriers of the CNS 2019 16:32

    Content type: Research

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  14. The blood–brain barrier (BBB) ensures central nervous system (CNS) homeostasis by strictly controlling the passage of molecules and solutes from the bloodstream into the CNS. Complex and continuous tight junct...

    Authors: Mariana Castro Dias, Caroline Coisne, Pascale Baden, Gaby Enzmann, Lillian Garrett, Lore Becker, Sabine M. Hölter, Martin Hrabě de Angelis, Urban Deutsch and Britta Engelhardt

    Citation: Fluids and Barriers of the CNS 2019 16:30

    Content type: Research

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  16. Following publication of the original article [1], the author has reported that in Figure 1 (b and c) the y-axis TEER (© x cm2) should be replaced with TEER (Ω x cm2).

    Authors: Scott G. Canfield, Matthew J. Stebbins, Madeline G. Faubion, Benjamin D. Gastfriend, Sean P. Palecek and Eric V. Shusta

    Citation: Fluids and Barriers of the CNS 2019 16:31

    Content type: Correction

    Published on:

    The original article was published in Fluids and Barriers of the CNS 2019 16:25

  17. Progressive multifocal leukoencephalopathy (PML), caused by infection with John Cunningham polyoma virus (JCPyV) in immune-compromised patients, is a serious demyelinating disease of the central nervous system...

    Authors: Nora Möhn, Yi Luo, Thomas Skripuletz, Philipp Schwenkenbecher, Inga Zerr, Peter Lange and Martin Stangel

    Citation: Fluids and Barriers of the CNS 2019 16:28

    Content type: Short paper

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  18. Human induced pluripotent stem cells (hiPSC) hold great promise for use in cell therapy applications and for improved in vitro models of human disease. So far, most hiPSC differentiation protocols to astroglia...

    Authors: Louise Delsing, Therése Kallur, Henrik Zetterberg, Ryan Hicks and Jane Synnergren

    Citation: Fluids and Barriers of the CNS 2019 16:27

    Content type: Research

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  19. Bacterial meningitis is a serious life threatening infection of the CNS. To cause meningitis, blood–borne bacteria need to interact with and penetrate brain endothelial cells (BECs) that comprise the blood–bra...

    Authors: Brandon J. Kim, Maura A. McDonagh, Liwen Deng, Benjamin D. Gastfriend, Alexandra Schubert-Unkmeir, Kelly S. Doran and Eric V. Shusta

    Citation: Fluids and Barriers of the CNS 2019 16:26

    Content type: Short paper

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  20. Brain microvascular endothelial cells (BMECs) astrocytes, neurons, and pericytes form the neurovascular unit (NVU). Interactions with NVU cells endow BMECs with extremely tight barriers via the expression of t...

    Authors: Scott G. Canfield, Matthew J. Stebbins, Madeline G. Faubion, Benjamin D. Gastfriend, Sean P. Palecek and Eric V. Shusta

    Citation: Fluids and Barriers of the CNS 2019 16:25

    Content type: Research

    Published on:

    The Correction to this article has been published in Fluids and Barriers of the CNS 2019 16:31

  21. The Kuopio University Hospital (KUH) idiopathic normal pressure hydrocephalus (iNPH) cerebrospinal fluid (CSF) shunting protocol is described together with the initial outcomes of 175 patients with probable iN...

    Authors: A. Junkkari, A. J. Luikku, N. Danner, H. K. Jyrkkänen, T. Rauramaa, V. E. Korhonen, A. M. Koivisto, O. Nerg, M. Kojoukhova, T. J. Huttunen, J. E. Jääskeläinen and V. Leinonen

    Citation: Fluids and Barriers of the CNS 2019 16:21

    Content type: Research

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  22. Blood–brain barrier dysfunction is associated with many late-stage neurodegenerative diseases. An emerging question is whether the mutations associated with neurodegenerative diseases can independently lead to...

    Authors: Moriah E. Katt, Lakyn N. Mayo, Shannon E. Ellis, Vasiliki Mahairaki, Jeffrey D. Rothstein, Linzhao Cheng and Peter C. Searson

    Citation: Fluids and Barriers of the CNS 2019 16:20

    Content type: Research

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  23. Solutes can enter and leave gray matter in the brain by perivascular routes. The glymphatic hypothesis supposes that these movements are a consequence of inward flow along periarterial spaces and an equal outw...

    Authors: Stephen B. Hladky and Margery A. Barrand

    Citation: Fluids and Barriers of the CNS 2019 16:24

    Content type: Letter to the Editor

    Published on:

    The original article was published in Fluids and Barriers of the CNS 2019 16:6

    The Letter to the Editor Response to this article has been published in Fluids and Barriers of the CNS 2019 16:23

  24. In our work, “Analysis of Convective and Diffusive Transport in the Brain Interstitium”, published in this journal (2019, 16:6), we estimate the interstitial superficial velocity by comparison of transport model ...

    Authors: Lori Ray, Jeffrey J. Iliff and Jeffrey J. Heys

    Citation: Fluids and Barriers of the CNS 2019 16:23

    Content type: Letter to the Editor Response

    Published on:

    The original article was published in Fluids and Barriers of the CNS 2019 16:24

  25. After publication of this supplement [1], it was brought to our attention that in the results the line “(0.3 ± 0.04 mmHg/μl/min, and 0.54 ± 0.04 mmHg/μl/min, respectively)” should actually read “(0.54 ± 0.04 m...

    Authors: Adjanie Patabendige, Nick MacKovski, Debbie Pepperall, Rebecca Hood and Neil Spratt

    Citation: Fluids and Barriers of the CNS 2019 16:22

    Content type: Correction

    Published on:

    The original article was published in Fluids and Barriers of the CNS 2019 16:16

  26. Immune cell trafficking into the CNS is considered to contribute to pathogenesis in MS and its animal model, EAE. Disruption of the blood–brain barrier (BBB) is a hallmark of these pathologies and a potential ...

    Authors: Shujun Ge, Xi Jiang, Debayon Paul, Li Song, Xiaofang Wang and Joel S. Pachter

    Citation: Fluids and Barriers of the CNS 2019 16:18

    Content type: Research

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  27. Periarterial spaces (PASs) are annular channels that surround arteries in the brain and contain cerebrospinal fluid (CSF): a flow of CSF in these channels is thought to be an important part of the brain’s syst...

    Authors: Jeffrey Tithof, Douglas H. Kelley, Humberto Mestre, Maiken Nedergaard and John H. Thomas

    Citation: Fluids and Barriers of the CNS 2019 16:19

    Content type: Research

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  29. Altered flow of cerebrospinal fluid (CSF) within the subarachnoid space (SAS) is connected to brain, but also optic nerve degenerative diseases. To overcome the lack of suitable in vitro models that faithfully...

    Authors: Albert Neutzner, Laura Power, Markus Dürrenberger, Hendrik P. N. Scholl, Peter Meyer, Hanspeter E. Killer, David Wendt and Corina Kohler

    Citation: Fluids and Barriers of the CNS 2019 16:17

    Content type: Research

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  30. Pericytes of the blood–brain barrier (BBB) are embedded within basement membrane between brain microvascular endothelial cells (BMECs) and astrocyte end-feet. Despite the direct cell–cell contact observed in v...

    Authors: John J. Jamieson, Raleigh M. Linville, Yuan Yuan Ding, Sharon Gerecht and Peter C. Searson

    Citation: Fluids and Barriers of the CNS 2019 16:15

    Content type: Research

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  31. Brain endothelial cell-based in vitro models are among the most versatile tools in blood–brain barrier research for testing drug penetration to the central nervous system. Transcytosis of large pharmaceuticals...

    Authors: Andrea E. Toth, Simone S. E. Nielsen, Weronika Tomaka, N. Joan Abbott and Morten S. Nielsen

    Citation: Fluids and Barriers of the CNS 2019 16:14

    Content type: Research

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  33. As an alternative to advection, solute transport by shear-augmented dispersion within oscillatory cerebrospinal fluid flow was investigated in small channels representing the basement membranes located between...

    Authors: M. Keith Sharp, Roxana O. Carare and Bryn A. Martin

    Citation: Fluids and Barriers of the CNS 2019 16:13

    Content type: Research

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  34. Fluid dynamics of the craniospinal system are complex and still not completely understood. In vivo flow and pressure measurements of the cerebrospinal fluid (CSF) are limited. Whereas in silico modeling can be...

    Authors: Anne Benninghaus, Olivier Balédent, Armelle Lokossou, Carlos Castelar, Steffen Leonhardt and Klaus Radermacher

    Citation: Fluids and Barriers of the CNS 2019 16:11

    Content type: Research

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  36. Respiration-induced pressure changes represent a powerful driving force of CSF dynamics as previously demonstrated using flow-sensitive real-time magnetic resonance imaging (MRI). The purpose of the present st...

    Authors: Gökmen Aktas, Jost M. Kollmeier, Arun A. Joseph, Klaus-Dietmar Merboldt, Hans-Christoph Ludwig, Jutta Gärtner, Jens Frahm and Steffi Dreha-Kulaczewski

    Citation: Fluids and Barriers of the CNS 2019 16:10

    Content type: Research

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  37. The central nervous system was previously thought to draw oxygen and nutrition from the arteries and discharge carbon dioxide and other metabolic wastes into the venous system. At present, the functional role ...

    Authors: Tetsuya Akaishi, Eiko Onishi, Michiaki Abe, Hiroaki Toyama, Kota Ishizawa, Michio Kumagai, Ryosuke Kubo, Ichiro Nakashima, Masashi Aoki, Masanori Yamauchi and Tadashi Ishii

    Citation: Fluids and Barriers of the CNS 2019 16:8

    Content type: Research

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  38. Fluid homeostasis in the central nervous system (CNS) is essential for normal neurological function. Cerebrospinal fluid (CSF) in the subarachnoid space and interstitial fluid circulation in the CNS parenchyma...

    Authors: Joel A. Berliner, Thomas Woodcock, Elmira Najafi, Sarah J. Hemley, Magdalena Lam, Shaokoon Cheng, Lynne E. Bilston and Marcus A. Stoodley

    Citation: Fluids and Barriers of the CNS 2019 16:7

    Content type: Research

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  39. Despite advances in in vivo imaging and experimental techniques, the nature of transport mechanisms in the brain remain elusive. Mathematical modelling verified using available experimental data offers a power...

    Authors: Lori Ray, Jeffrey J. Iliff and Jeffrey J. Heys

    Citation: Fluids and Barriers of the CNS 2019 16:6

    Content type: Research

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    The Letter to the Editor to this article has been published in Fluids and Barriers of the CNS 2019 16:24

  40. Idiopathic normal pressure hydrocephalus (iNPH) is a subtype of hydrocephalus that occurs more often in the elderly population. It is usually characterized by gait disturbance, dementia and urinary incontinenc...

    Authors: Miles Hudson, Caden Nowak, Richard J. Garling and Carolyn Harris

    Citation: Fluids and Barriers of the CNS 2019 16:5

    Content type: Review

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  42. Tight junction proteins of the blood–brain barrier are vital for maintaining integrity of endothelial cells lining brain blood vessels. The presence of these protein complexes in the space between endothelial ...

    Authors: Chris Greene, Nicole Hanley and Matthew Campbell

    Citation: Fluids and Barriers of the CNS 2019 16:3

    Content type: Review

    Published on:

  43. This study investigated cerebrospinal fluid (CSF) hydrodynamics using cine phase-contrast MRI in the cerebral aqueduct and the prepontine cistern between three distinct groups: pre-shunt normal pressure hydroc...

    Authors: Robert B. Hamilton, Fabien Scalzo, Kevin Baldwin, Amber Dorn, Paul Vespa, Xiao Hu and Marvin Bergsneider

    Citation: Fluids and Barriers of the CNS 2019 16:2

    Content type: Research

    Published on:

  44. Type II diabetes is a vascular risk factor for cognitive impairment and increased risk of dementia. Disruption of the blood–retinal barrier (BRB) and blood–brain barrier (BBB) are hallmarks of subsequent retin...

    Authors: Therese S. Salameh, William G. Mortell, Aric F. Logsdon, D. Allan Butterfield and William A. Banks

    Citation: Fluids and Barriers of the CNS 2019 16:1

    Content type: Research

    Published on:

  46. Type 1 Chiari malformation (CM-I) has been historically defined by cerebellar tonsillar position (TP) greater than 3–5 mm below the foramen magnum (FM). Often, the radiographic findings are highly variable, wh...

    Authors: Braden J. Lawrence, Aintzane Urbizu, Philip A. Allen, Francis Loth, R. Shane Tubbs, Alexander C. Bunck, Jan-Robert Kröger, Brandon G. Rocque, Casey Madura, Jason A. Chen, Mark G. Luciano, Richard G. Ellenbogen, John N. Oshinski, Bermans J. Iskandar and Bryn A. Martin

    Citation: Fluids and Barriers of the CNS 2018 15:33

    Content type: Research

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  47. The roles of the choroid plexus (CP) and cerebrospinal fluid (CSF) production have drawn increasing attention in Alzheimer’s disease (AD) research. Specifically, studies document markedly decreased CSF product...

    Authors: Shawn Kant, Edward G. Stopa, Conrad E. Johanson, Andrew Baird and Gerald D. Silverberg

    Citation: Fluids and Barriers of the CNS 2018 15:34

    Content type: Research

    Published on:

  48. The blood–brain barrier (BBB) plays a key role in regulating transport into and out of the brain. With increasing interest in the role of the BBB in health and disease, there have been significant advances in ...

    Authors: Jackson G. DeStefano, John J. Jamieson, Raleigh M. Linville and Peter C. Searson

    Citation: Fluids and Barriers of the CNS 2018 15:32

    Content type: Review

    Published on:

  49. The distribution of cranio-spinal compliance (CSC) in the brain and spinal cord is a fundamental question, as it would determine the overall role of the compartments in modulating ICP in healthy and diseased s...

    Authors: Ritambhar Burman, Noam Alperin, Sang H. Lee and Brigit Ertl-Wagner

    Citation: Fluids and Barriers of the CNS 2018 15:29

    Content type: Research

    Published on:

  50. Cerebrospinal fluid (CSF) analysis is a crucial method in the diagnostic process for suspected subarachnoid hemorrhage (SAH), especially when cerebral imaging is negative or inconclusive. CSF cytology (detecti...

    Authors: R. Dersch, D. Benkler, T. Robinson, A. Baumgartner, S. Rauer and O. Stich

    Citation: Fluids and Barriers of the CNS 2018 15:31

    Content type: Short paper

    Published on:

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  • ISSN: 2045-8118 (electronic)

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Fluids and Barriers of the CNS

ISSN: 2045-8118