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Fluids and Barriers of the CNS
Affiliated with:
Research
Neoplastic invasion into leptomeninges and subarachnoid space, resulting in neoplastic meningitis (NM) is a fatal complication of advanced solid and hematological neoplasms. Identification of malignant involve...
Fluids and Barriers of the CNS 2017 14:22
Published on: 14 August 2017
Research
The endothelial cells that form the lumen of capillaries and microvessels are an important component of the blood–brain barrier. Cell phenotype is regulated by transducing a range of biomechanical and biochemi...
Fluids and Barriers of the CNS 2017 14:20
Published on: 4 August 2017
Erratum
Fluids and Barriers of the CNS 2017 14:21
Published on: 4 August 2017
Review
Despite decades of research, no compelling non-surgical therapies have been developed for foetal hydrocephalus. So far, most efforts have pointed to repairing disturbances in the cerebrospinal fluid (CSF) flow...
Fluids and Barriers of the CNS 2017 14:19
Published on: 13 July 2017
Short Paper
There is evidence that patients with multiple sclerosis (MS) and hydrocephalus share some common pathophysiological mechanisms. Alterations in CSF pressure are known to affect cerebral venous sinus geometry. T...
Fluids and Barriers of the CNS 2017 14:18
Published on: 6 July 2017
Research
Intracranial pressure (ICP) is directly related to cranial dural venous pressure (P dural ). In the upright posture, P
Fluids and Barriers of the CNS 2017 14:17
Published on: 17 June 2017
Meeting abstracts
Fluids and Barriers of the CNS 2017 14(Suppl 1):15
Published on: 7 June 2017
This article is part of a Supplement: Volume 14 Supplement 1
Research
The radiologic features and patterns of primary central nervous system lymphoma (PCNSL) at initial presentation are well described. High response rates can be achieved with first-line high-dose methotrexate (H...
Fluids and Barriers of the CNS 2017 14:16
Published on: 2 June 2017
Research
Cerebrospinal fluid (CSF) protein analysis is an important element in the diagnostic chain for various central nervous system (CNS) pathologies. Among multiple existing approaches to interpreting measured prot...
Fluids and Barriers of the CNS 2017 14:14
Published on: 18 May 2017
Review
The purpose of this systematic review and meta-analysis was to evaluate the performance of cerebrospinal fluid (CSF) beta amyloid 42 (Aβ42), total tau (t-tau), and phosphorylated tau (p-tau) as potential diagn...
Fluids and Barriers of the CNS 2017 14:13
Published on: 10 May 2017
Review
A trans-agency workshop on the blood–brain interface (BBI), sponsored by the National Heart, Lung and Blood Institute, the National Cancer Institute and the Combat Casualty Care Research Program at the Departm...
Fluids and Barriers of the CNS 2017 14:12
Published on: 1 May 2017
Research
HIV-associated neurocognitive disorder (HAND) remains common, despite antiretroviral therapy (ART). HIV dysregulates iron metabolism, but cerebrospinal fluid (CSF) levels of iron and iron-transport proteins in...
Fluids and Barriers of the CNS 2017 14:11
Published on: 21 April 2017
Short Paper
Behavioural variant frontotemporal dementia (bvFTD) and idiopathic normal pressure hydrocephalus (iNPH) are neurodegenerative diseases that can present with similar symptoms. These include decline in executive...
Fluids and Barriers of the CNS 2017 14:10
Published on: 19 April 2017
Research
Due to their ability to limitlessly proliferate and specialize into almost any cell type, human induced pluripotent stem cells (iPSCs) offer an unprecedented opportunity to generate human brain microvascular e...
Fluids and Barriers of the CNS 2017 14:9
Published on: 13 April 2017
Review
While the impact of hemorrhagic and ischemic strokes on the blood–brain barrier has been extensively studied, the impact of these types of stroke on the choroid plexus, site of the blood-CSF barrier, has recei...
Fluids and Barriers of the CNS 2017 14:8
Published on: 28 March 2017
Research
Meningeosis neoplastica is a diffuse metastatic spread of tumor cells in the subarachnoid space. Although first recognized in 1870, systematic investigations regarding cerebrospinal fluid (CSF) constituents in...
Fluids and Barriers of the CNS 2017 14:7
Published on: 28 March 2017
Research
Strategies to maintain BBB integrity in diseases with a hypoxia/reoxygenation (H/R) component involve preventing glutathione (GSH) loss from endothelial cells. GSH efflux transporters include multidrug resista...
Fluids and Barriers of the CNS 2017 14:6
Published on: 16 March 2017
Research
Postural changes are related to changes in cerebrospinal fluid (CSF) dynamics. While sitting up leads to a decrease in cranial CSF pressure, it also causes shifts in the craniospinal CSF volume and compliance ...
Fluids and Barriers of the CNS 2017 14:5
Published on: 16 February 2017
Research
The MRZ reaction (MRZR), composed of the three antibody indices (AI) against measles, rubella and varicella zoster virus and found positive in the majority of relapsing-remitting multiple sclerosis (RRMS) pati...
Fluids and Barriers of the CNS 2017 14:2
Published on: 7 February 2017
Editorial
This editorial highlights some of the advances that occurred in relation to brain barriers and brain fluid research in 2016. It also aims to raise some of the attendant controversies and challenges in such res...
Fluids and Barriers of the CNS 2017 14:4
Published on: 2 February 2017
Research
The aim of this study was to elucidate changes in cerebral white matter after shunt surgery in idiopathic normal pressure hydrocephalus (INPH) using diffusion tensor imaging (DTI).
Fluids and Barriers of the CNS 2017 14:1
Published on: 30 January 2017
Research
The lack of translatable in vitro blood-tumor barrier (BTB) models creates challenges in the development of drugs to treat tumors of the CNS and our understanding of how the vascular changes at the BBB in the ...
Fluids and Barriers of the CNS 2017 14:3
Published on: 23 January 2017
Research
Neovascularization, a distinguishing trait of high-grade glioma, is a target for anti-angiogenic treatment with bevacizumab (BEV). This study sought to use ferumoxytol-based dynamic susceptibility contrast mag...
Fluids and Barriers of the CNS 2016 13:23
Published on: 20 December 2016
Research
Uric acid (UA) is known to exert neuroprotective effects in the brain. However, the mechanism of UA regulation in the brain is not well characterized. In our previous study, we described that the mouse urate t...
Fluids and Barriers of the CNS 2016 13:22
Published on: 12 December 2016
Research
Blood biomarkers of neurovascular damage are used clinically to diagnose the presence severity or absence of neurological diseases, but data interpretation is confounded by a limited understanding of their dep...
Fluids and Barriers of the CNS 2016 13:21
Published on: 30 November 2016
