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Aims and scope

Fluids and Barriers of the CNS is an open access, peer-reviewed, online journal that considers manuscripts on all CNS fluids and barrier systems in health and disease.

Fluids and Barriers of the CNS is affiliated to the International Brain Barriers Society (IBBS) and the International Society for Hydrocephalus and CSF Disorders (ISHCSF). 


Article collections

Thematic Series
Advances in in vitro modeling of the blood-brain barrier and neurovascular unit
Fluids and Barriers of the CNS

Thematic series
CNS Fluid and Solute Movement: Physiology, Modelling and Imaging
Fluids and Barriers of the CNS

Thematic series
Brain barriers and their microenvironment: Emerging models and techniques
Edited by Danica Stanimirovic, Britta Engelhardt, Elizabeth de Lange

View all article collections

Latest supplements

Abstracts from Hydrocephalus 2021 - The Thirteenth Meeting of the International Society for Hydrocephalus and Cerebrospinal Fluid Disorders
Volume 18 Supplement 2
Meeting abstracts
Virtual. 10-13 September 2021

Abstracts from the Virtual Symposium “Signal Transduction at the Blood-Brain Barriers”
Volume 18 Supplement 1
Meeting abstracts
Virtual. 22-24 September 2021

View all supplements

About the Editors

Lester R Drewes, Editor-in-Chief

Lester Drewes is currently Professor  of Biochemistry and Molecular Biology at the University of Minnesota Duluth Medical School, and past President of the International Brain Barriers Society. Read more

Hazel C Jones, Editor-in-Chief

Hazel Jones is Visiting Senior Research Fellow, Institute of Pharmaceutical Sciences, King's College London and lately Courtesy Research Professor, Department of Pharmacology and Therapeutics, University of Florida. Read more

Richard F Keep, Editor-in-Chief

Richard Keep is currently Professor in the Department of Neurosurgery and in the Department of Molecular and Integrative Physiology at the University of Michigan. He is also Director of the Crosby Neurosurgical Laboratories and Associate Chair for Research in Neurosurgery. Read more


Lester R Drewes, University of Minnesota, USA
Hazel C Jones, King's College London, UK
Richard F Keep, University of Michigan, USA

Society affiliations

International Brain Barriers Society (IBBS)

New Content ItemFluids and Barriers of the CNS is an official journal of the IBBS: a scientific and educational non-profit organisation advocating scientific and clinical research on the biological barriers in the central nervous system.

International Society for Hydrocephalus and CSF Disorders (ISHCSF)

Fluids and Barriers of the CNS is an official journal of the ISHCSF: a non-profit organisation that aims to advance the art and science of clinical care and research into hydrocephalus and CSF disorders, and promote the best possible care for patients.

All IBBS and ISHCSF members are eligible for a 15% discount when publishing with Fluids and Barriers of the CNS.

Read more

Journal News

We are pleased to announce that the official 2-year impact factor of FBCNS for 2021 is now 6.961, with a ranking between 84th and 93rd percentile among Neuroscience journals.

New Thematic Series - Open for Submission

Genetic disorders and genetic manipulation at the blood-brain barriers

This series addresses how genetic mutations in humans can impact barrier and NVU function leading to pathology, how experimental gene deletion and overexpression studies provide insights into the barriers and NVU, and how model systems have advanced the field.

Latest Review

The impact of genetic manipulation of laminin and integrins at the blood–brain barrier.

Blood vessels in the central nervous system (CNS) are unique in having high electrical resistance and low permeability, which creates a selective barrier protecting sensitive neural cells within the CNS from potentially harmful components in the blood...

Authors: Sebok K. Halder, Arjun Sapkota and Richard Milner 

Citation: Fluids and Barriers of the CNS 2022 19:50

Published on: 11 June 2022

Featured Article

Claudin-5a is essential for the functional formation of both zebrafish blood-brain barrier and blood-cerebrospinal fluid barrier 

Mammalian Claudin-5 is the main endothelial tight junction component maintaining blood-brain barrier (BBB) permeability, while Claudin-1 and -3 seal the paracellular space of choroid plexus (CP) epithelial cells contributing to the blood-cerebrospinal fluid barrier (BCSFB). In zebrafish,... 

Authors: Yanyu Li, Chunchun Wang, Liang Zhang, Bing Chen, Yuqian Mo and Jingjing Zhang

Citation: Fluids and Barriers of the CNS 2022 19:40 

Published on: 03 June 2022

Scimago journal rank

FBCNS is ranked in the top quartile of the Developmental Neuroscience, Neurology and Neuroscience subject categories, by SCImago Journal Rank.

2022 Best Presentation Winners - Hydrocephalus 2022 Conference

We are pleased to announce the winners of the awards for best presentations sponsored by the International Society for Hydrocephalus and CSF Disorders and by Fluids and Barriers of the CNS at this year’s Hydrocephalus conference, September 9-12, Gothenburg Sweden.

Find out more about the winners here.

Forthcoming Conferences

Barriers of the CNS Gordon Research Conference; Colby-Sawyer College in New London, New Hampshire, USA, June 12-17, 2022.

13th Meeting of the Hydrocephalus Society (International Society for Hydrocephalus and CSF Disorders); Hydrocephalus 2022, Gothenburg,  Sweden,  September 9-12, 2022.

Society for Research into Hydrocephalus and Spina Bifida: 66th Annual Meeting and Sidra Pediatric Neuroscience Hybrid Conference: 29th September – 1st October 2022, Doha Qatar.

Cerebral Vascular Biology meeting Uppsala, Sweden 2021 has been withdrawn and rescheduled for June 18 – 22, 2023 in Uppsala.

24rd International Symposium on Signal Transduction at the Blood-Brain Barriers; Bari, Italy, September 21-23 September 2022.

International Society for Magnetic Resonance in Medicine (ISMRM): workshop on Neurofluids 21-24 September 2022, Rome Italy. Co-chairs Nivedita Agrawal and Olivier Baledent.

11th International Symposium on Neuroprotection and Neurorepair (ISN&N) and the 18th International Conference on Brain Edema and Cellular Injury (BEM); Berlin, Germany, October 5-7, 2020 This conference has been postponed until 2022.

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