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Table 3 Effect of intracerebral pre-administration of antibiotics and NSAIDs (5 mM) on [3H]PGE2 elimination from brain across the BBB in LPS-treated mice.

From: Attenuation of prostaglandin E2 elimination across the mouse blood-brain barrier in lipopolysaccharide-induced inflammation and additive inhibitory effect of cefmetazole

Compound Percentage of [3H]PGE2 remaining
in ipsilateral cerebrum (100-BEI, %)
Percentage of control
Cephalosporins  
Control 91.9 ± 6.6 100
Cefmetazole 133 ± 16* 146
Cefotaxime 136 ± 1* 149
Ceftriaxone 113 ± 11 124
Cefsulodin 94.2 ± 15.3 103
Cefazolin 85.7 ± 6.2 94.0
Other antibiotics and NSAIDs  
Control
(0.25% DMSO)
97.2 ± 11.1 100
Indomethacin
(0.25% DMSO)
114 ± 9 117
Ketoprofen
(0.25% DMSO)
82.8 ± 5.8 85.2
Clarithromycin
(0.25% DMSO)
82.2 ± 16.4 84.6
  1. Each compound or ECF buffer with or without 0.25% DMSO (control) was administered at 5 min prior to administration of [3H]PGE2 in the brain of LPS-treated mice. The percentage of [3H]PGE2 in the ipsilateral cerebrum was determined at 40 min after intracerebral [3H]PGE2 microinjection. Each value represents the mean ± S.E.M. (n = 3-8). *p < 0.05, significantly different from control.