Inhibitory effect of intracerebral pre-administration of cefmetazole or cefazolin on [3H]PGE
elimination from the brain of LPS-untreated mice in the presence of benzylpenicillin and digoxin. Either cefmetazole (5 mM) or cefazolin (5 mM) or ECF buffer (ECF, control) was co-administered with 100 μM benzylpenicillin and 20 μM digoxin to the S2 region 5 min prior to administration of [3H]PGE2 in the brain of mice without LPS treatment. The 100-BEI value was determined 40 min after intracerebral microinjection of [3H]PGE2. Each column represents the mean ± S.E.M. (n = 3). **p < 0.01, significantly different from control.