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Table 2 Expression level of organic anion transporters in brain capillaries of LPS-treated mice and saline-treated mice.

From: Attenuation of prostaglandin E2 elimination across the mouse blood-brain barrier in lipopolysaccharide-induced inflammation and additive inhibitory effect of cefmetazole

  Protein expression level (fmol/μg protein)  
Transporter Saline 3 mg/kg LPS Ratio
(LPS/Saline)
Mrp4 1.80 ± 0.20 1.50 ± 0.13 0.833
Oat3 1.25 ± 0.08 0.929 ± 0.068* 0.743
Oatp1a4 2.46 ± 0.31 1.50 ± 0.14** 0.610
Pgt N.D. N.D. -
  1. Brain capillary-enriched fraction was prepared from ddY mice intraperitoneally injected with 3 mg/kg LPS or saline. The fraction was digested with trypsin and the digest was injected into LC-MS/MS together with internal standard peptides. Each value represents the mean ± S.E.M. (n = 4). *p < 0.05 and **p < 0.01, significantly different from the saline-treated mice. N.D: not detected.