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Table 2 Expression level of organic anion transporters in brain capillaries of LPS-treated mice and saline-treated mice.

From: Attenuation of prostaglandin E2 elimination across the mouse blood-brain barrier in lipopolysaccharide-induced inflammation and additive inhibitory effect of cefmetazole

 

Protein expression level (fmol/μg protein)

 

Transporter

Saline

3 mg/kg LPS

Ratio

(LPS/Saline)

Mrp4

1.80 ± 0.20

1.50 ± 0.13

0.833

Oat3

1.25 ± 0.08

0.929 ± 0.068*

0.743

Oatp1a4

2.46 ± 0.31

1.50 ± 0.14**

0.610

Pgt

N.D.

N.D.

-

  1. Brain capillary-enriched fraction was prepared from ddY mice intraperitoneally injected with 3 mg/kg LPS or saline. The fraction was digested with trypsin and the digest was injected into LC-MS/MS together with internal standard peptides. Each value represents the mean ± S.E.M. (n = 4). *p < 0.05 and **p < 0.01, significantly different from the saline-treated mice. N.D: not detected.