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Fluids and Barriers of the CNS
Affiliated with:
Research
To improve the diagnostic performance of the cerebrospinal fluid (CSF) tap test (TT), early and delayed assessments of gait were performed after the removal of 30 ml of CSF in patients with probable idiopathic...
Fluids and Barriers of the CNS 2016 13:20
Published on: 22 November 2016
Review
The two major interfaces separating brain and blood have different primary roles. The choroid plexuses secrete cerebrospinal fluid into the ventricles, accounting for most net fluid entry to the brain. Aquapor...
Fluids and Barriers of the CNS 2016 13:19
Published on: 31 October 2016
Research
Cerebral hypoxia/ischemia (H/I) is an important stress factor involved in the disruption of the blood–brain barrier (BBB) following stroke injury, yet the cellular and molecular mechanisms on how the human BBB...
Fluids and Barriers of the CNS 2016 13:16
Published on: 11 October 2016
Research
It has been suggested there is a chronic neurodegenerative disorder, underlying the pathophysiology of multiple sclerosis (MS), which is distinct from the more obvious immune-mediated attack on the white matte...
Fluids and Barriers of the CNS 2016 13:18
Published on: 22 September 2016
Review
Annexin A1 is a potent anti-inflammatory molecule that has been extensively studied in the peripheral immune system, but has not as yet been exploited as a therapeutic target/agent. In the last decade, we have...
Fluids and Barriers of the CNS 2016 13:17
Published on: 21 September 2016
Research
The composition of the cerebrospinal fluid (CSF) is not homogeneous, and concentrations of proteins from different origins diverge among ventricular, cisternal and lumbar CSF fractions. Concentrations of blood...
Fluids and Barriers of the CNS 2016 13:15
Published on: 31 August 2016
Research
Transport across the blood–brain barrier (BBB) is an important mediator of beta-amyloid (Aβ) accumulation in the brain and a contributing factor in the pathogenesis of Alzheimer’s disease (AD). One of the rece...
Fluids and Barriers of the CNS 2016 13:14
Published on: 8 August 2016
Research
Patients with idiopathic normal pressure hydrocephalus (iNPH) have reduced cerebrospinal fluid (CSF) concentrations of amyloid-β (Aβ) and α- and β-cleaved soluble forms of amyloid precursor protein (sAPPα and ...
Fluids and Barriers of the CNS 2016 13:13
Published on: 29 July 2016
Research
Current therapies for organophosphate poisoning involve administration of oximes, such as pralidoxime (2-PAM), that reactivate the enzyme acetylcholinesterase. Studies in animal models have shown a low concent...
Fluids and Barriers of the CNS 2016 13:10
Published on: 11 July 2016
Research
Studies in animal models, in which internal hydrocephalus has been induced by obstructing the cerebrospinal fluid pathways, have documented an up-regulation of the concentrations of aquaporin-4 (AQP4) in the b...
Fluids and Barriers of the CNS 2016 13:12
Published on: 29 June 2016
Research
Cerebrospinal fluid (CSF) contained within the brain ventricles contacts neuroepithelial progenitor cells during brain development. Dynamic properties of CSF movement may limit locally produced factors to spec...
Fluids and Barriers of the CNS 2016 13:11
Published on: 21 June 2016
Research
In an effort to develop novel treatments for communicating hydrocephalus, we have shown previously that the transforming growth factor-β antagonist, decorin, inhibits subarachnoid fibrosis mediated ventriculom...
Fluids and Barriers of the CNS 2016 13:9
Published on: 31 May 2016
Research paper
Increased leukocyte adhesion to brain endothelial cells forming the blood–brain barrier (BBB) precedes extravasation into the central nervous system (CNS) in neuroinflammatory diseases such as multiple scleros...
Fluids and Barriers of the CNS 2016 13:8
Published on: 31 May 2016
Research
Previous work with 3-week hydrocephalic rats showed that white matter damage could be reduced by the calcium channel antagonist magnesium sulfate (MgSO4). We hypothesized that MgSO4 therapy would improve outcomes...
Fluids and Barriers of the CNS 2016 13:7
Published on: 27 April 2016
Research
Patient-derived induced pluripotent stem cells (iPSCs) are an innovative source as an in vitro model for neurological diseases. Recent studies have demonstrated the differentiation of brain microvascular endot...
Fluids and Barriers of the CNS 2016 13:6
Published on: 12 April 2016
Review
Within the consolidated field of evolutionary development, there is emerging research on evolutionary aspects of central nervous system development and its implications for adult brain structure and function, ...
Fluids and Barriers of the CNS 2016 13:5
Published on: 15 March 2016
Short paper
A vascular disease could be involved in pathophysiology of normal pressure hydrocephalus (INPH). If so, there should be an association between INPH and cerebral microbleeds (CMB). This study aims to analyze if...
Fluids and Barriers of the CNS 2016 13:4
Published on: 10 February 2016
Review
Pharmacological interventions have been tested experimentally and clinically to prevent hydrocephalus and avoid the need for shunting beginning in the 1950s. Clinical trials of varied quality have not demonstr...
Fluids and Barriers of the CNS 2016 13:3
Published on: 5 February 2016
Research
The blood–cerebrospinal fluid barrier (BCSFB) established by the choroid plexus (CP) epithelium has been recognized as a potential entry site of immune cells into the central nervous system during immunosurvei...
Fluids and Barriers of the CNS 2016 13:2
Published on: 29 January 2016
Editorial
Research into brain barriers and brain fluids has been advancing rapidly in recent years. This editorial aims to highlight some of the advances that have improved our understanding of this complex subject. It ...
Fluids and Barriers of the CNS 2016 13:1
Published on: 28 January 2016
Research
A polyspecific, intrathecal humoral immune response against the neurotropic viruses, measles, rubella and varicella zoster virus, called “MRZ reaction” (MRZR), is present in the majority of patients with multi...
Fluids and Barriers of the CNS 2015 12:27
Published on: 13 December 2015
Research
Shunt obstruction in the treatment of hydrocephalus is poorly understood, is multi-factorial, and in many cases is modeled ineffectively. Several mechanisms may be responsible, one of which involves shunt infi...
Fluids and Barriers of the CNS 2015 12:26
Published on: 14 November 2015
Review
Tobacco smoke (TS) is the leading cause of preventable deaths worldwide. In addition to a host of well characterized diseases including chronic obstructive pulmonary disease, oral and peripheral cancers and ca...
Fluids and Barriers of the CNS 2015 12:25
Published on: 31 October 2015
Study protocol
Imaging of the brain surface vasculature following inflammatory insults is critical to study structural and functional changes in the living brain under normal and pathological conditions. Although there have ...
Fluids and Barriers of the CNS 2015 12:24
Published on: 27 October 2015
Research
In the absence of a true lymphatic system in the brain parenchyma, alternative clearance pathways for excess fluid and waste products have been proposed. Suggested mechanisms for clearance implicate a role for...
Fluids and Barriers of the CNS 2015 12:23
Published on: 5 October 2015
