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  1. Research

    LDL receptor blockade reduces mortality in a mouse model of ischaemic stroke without improving tissue-type plasminogen activator-induced brain haemorrhage: towards pre-clinical simulation of symptomatic ICH

    Symptomatic intracerebral haemorrhage (sICH) following tissue-type plasminogen activator (rt-PA) administration is the most feared and lethal complication of thrombolytic therapy for ischaemic stroke, creating...

    Be’eri Niego, Brad R. S. Broughton, Heidi Ho, Christopher G. Sobey and Robert L. Medcalf

    Fluids and Barriers of the CNS 2017 14:33

    Published on: 21 November 2017

  2. Review

    Current research into brain barriers and the delivery of therapeutics for neurological diseases: a report on CNS barrier congress London, UK, 2017

    This is a report on the CNS barrier congress held in London, UK, March 22–23rd 2017 and sponsored by Kisaco Research Ltd. The two 1-day sessions were chaired by John Greenwood and Margareta Hammarlund-Udenaes,...

    John Greenwood, Margareta Hammarlund-Udenaes, Hazel C. Jones, Alan W. Stitt, Roosmarijn E. Vandenbrouke, Ignacio A. Romero, Matthew Campbell, Gert Fricker, Birger Brodin, Heiko Manninga, Pieter J. Gaillard, Markus Schwaninger, Carl Webster, Krzysztof B. Wicher and Michel Khrestchatisky

    Fluids and Barriers of the CNS 2017 14:31

    Published on: 7 November 2017

  3. Research

    Revisiting atenolol as a low passive permeability marker

    Atenolol, a hydrophilic beta blocker, has been used as a model drug for studying passive permeability of biological membranes such as the blood–brain barrier (BBB) and the intestinal epithelium. However, the e...

    Xiaomei Chen, Tim Slättengren, Elizabeth C. M. de Lange, David E. Smith and Margareta Hammarlund-Udenaes

    Fluids and Barriers of the CNS 2017 14:30

    Published on: 31 October 2017

  4. Meeting abstracts

    Abstracts from the 20th International Symposium on Signal Transduction at the Blood-Brain Barriers

    Andrzej Małecki, Janina Skipor-Lahuta, Michal Toborek, N. Joan Abbott, David A. Antonetti, Enming Joe Su, Daniel A. Lawrence, Müge Atış, Uğur Akcan, Canan Uğur Yılmaz, Nurcan Orhan, Poyraz Düzgün, Umut Deniz Ceylan, Nadir Arıcan, Serçin Karahüseyinoğlu, Gizem Nur Şahin…

    Fluids and Barriers of the CNS 2017 14(Suppl 2):27

    Published on: 27 October 2017

    This article is part of a Supplement: Volume 14 Supplement 2

  5. Research

    Hyperdynamic CSF motion profiles found in idiopathic normal pressure hydrocephalus and Alzheimer’s disease assessed by fluid mechanics derived from magnetic resonance images

    Magnetic resonance imaging (MRI) does not only ascertain morphological features, but also measures physiological properties such as fluid velocity or pressure gradient. The purpose of this study was to investi...

    Ken Takizawa, Mitsunori Matsumae, Naokazu Hayashi, Akihiro Hirayama, Satoshi Yatsushiro and Kagayaki Kuroda

    Fluids and Barriers of the CNS 2017 14:29

    Published on: 18 October 2017

  6. Correction

    Correction to: Correlation of CSF flow using phase-contrast MRI with ventriculomegaly and CSF opening pressure in mucopolysaccharidoses

    After publication of the article [1], it has been brought to our attention that the full funding acknowledgement is missing from the original article.

    Amauri Dalla Corte, Carolina F. M. de Souza, Maurício Anés, Fabio K. Maeda, Armelle Lokossou, Leonardo M. Vedolin, Maria Gabriela Longo, Monica M. Ferreira, Solanger G. P. Perrone, Olivier Balédent and Roberto Giugliani

    Fluids and Barriers of the CNS 2017 14:28

    Published on: 13 October 2017

    The original article was published in Fluids and Barriers of the CNS 2017 14:23

  7. Research

    Dose escalation study of intravenous and intra-arterial N-acetylcysteine for the prevention of oto- and nephrotoxicity of cisplatin with a contrast-induced nephropathy model in patients with renal insufficiency

    Cisplatin neuro-, oto-, and nephrotoxicity are major problems in children with malignant tumors, including medulloblastoma, negatively impacting educational achievement, socioemotional development, and overall...

    Edit Dósa, Krisztina Heltai, Tamás Radovits, Gabriella Molnár, Judit Kapocsi, Béla Merkely, Rongwei Fu, Nancy D. Doolittle, Gerda B. Tóth, Zachary Urdang and Edward A. Neuwelt

    Fluids and Barriers of the CNS 2017 14:26

    Published on: 3 October 2017

  8. Research

    Characterization of cardiac- and respiratory-driven cerebrospinal fluid motion based on asynchronous phase-contrast magnetic resonance imaging in volunteers

    A classification of cardiac- and respiratory-driven components of cerebrospinal fluid (CSF) motion has been demonstrated using echo planar imaging and time-spatial labeling inversion pulse techniques of magnet...

    Ken Takizawa, Mitsunori Matsumae, Saeko Sunohara, Satoshi Yatsushiro and Kagayaki Kuroda

    Fluids and Barriers of the CNS 2017 14:25

    Published on: 27 September 2017

  9. Research

    Correlation of CSF flow using phase-contrast MRI with ventriculomegaly and CSF opening pressure in mucopolysaccharidoses

    Very little is known about the incidence and prevalence of hydrocephalus in patients with mucopolysaccharidoses (MPS). The biggest challenge is to distinguish communicating hydrocephalus from ventricular dilat...

    Amauri Dalla Corte, Carolina F. M. de Souza, Maurício Anés, Fabio K. Maeda, Armelle Lokossou, Leonardo M. Vedolin, Maria Gabriela Longo, Monica M. Ferreira, Solanger G. P. Perrone, Olivier Balédent and Roberto Giugliani

    Fluids and Barriers of the CNS 2017 14:23

    Published on: 18 September 2017

    The Correction to this article has been published in Fluids and Barriers of the CNS 2017 14:28

  10. Research

    The role of perfusion and diffusion MRI in the assessment of patients affected by probable idiopathic normal pressure hydrocephalus. A cohort-prospective preliminary study

    Invasive tests measuring resistance to cerebral spinal fluid (CSF) outflow and the effect of temporary drainage of CSF are used to select candidates affected by idiopathic normal pressure hydrocephalus (iNPH) ...

    Francesco Tuniz, Maria Caterina Vescovi, Daniele Bagatto, Daniela Drigo, Maria Cristina De Colle, Marta Maieron and Miran Skrap

    Fluids and Barriers of the CNS 2017 14:24

    Published on: 12 September 2017

  11. Research

    Profiling of metalloprotease activities in cerebrospinal fluids of patients with neoplastic meningitis

    Neoplastic invasion into leptomeninges and subarachnoid space, resulting in neoplastic meningitis (NM) is a fatal complication of advanced solid and hematological neoplasms. Identification of malignant involve...

    Catharina Conrad, Kristina Dorzweiler, Miles A. Miller, Douglas A. Lauffenburger, Herwig Strik and Jörg W. Bartsch

    Fluids and Barriers of the CNS 2017 14:22

    Published on: 14 August 2017

  12. Short Paper

    Comparison of the sagittal sinus cross-sectional area between patients with multiple sclerosis, hydrocephalus, intracranial hypertension and spontaneous intracranial hypotension: a surrogate marker of venous transmural pressure?

    There is evidence that patients with multiple sclerosis (MS) and hydrocephalus share some common pathophysiological mechanisms. Alterations in CSF pressure are known to affect cerebral venous sinus geometry. T...

    Grant A. Bateman, Jeannette Lechner-Scott, Ross Copping, Christopher Moeskops and Swee Leong Yap

    Fluids and Barriers of the CNS 2017 14:18

    Published on: 6 July 2017

  13. Meeting abstracts

    Abstracts from Hydrocephalus 2016

    A. Adam, J. Robison, J. Lu, R. Jose, N. Badran, T. Vivas-Buitrago, D. Rigamonti, A. Sattar, O. Omoush, M. Hammad, M. Dawood, M. Maghaslah, T. Belcher, K. Carson, J. Hoffberger, I. Jusué Torres…

    Fluids and Barriers of the CNS 2017 14(Suppl 1):15

    Published on: 7 June 2017

    This article is part of a Supplement: Volume 14 Supplement 1

  14. Research

    Patterns of relapse in primary central nervous system lymphoma: inferences regarding the role of the neuro-vascular unit and monoclonal antibodies in treating occult CNS disease

    The radiologic features and patterns of primary central nervous system lymphoma (PCNSL) at initial presentation are well described. High response rates can be achieved with first-line high-dose methotrexate (H...

    Prakash Ambady, Rongwei Fu, Joao Prola Netto, Cymon Kersch, Jenny Firkins, Nancy D. Doolittle and Edward A. Neuwelt

    Fluids and Barriers of the CNS 2017 14:16

    Published on: 2 June 2017

  15. Review

    Cerebrospinal fluid Aβ42, t-tau, and p-tau levels in the differential diagnosis of idiopathic normal-pressure hydrocephalus: a systematic review and meta-analysis

    The purpose of this systematic review and meta-analysis was to evaluate the performance of cerebrospinal fluid (CSF) beta amyloid 42 (Aβ42), total tau (t-tau), and phosphorylated tau (p-tau) as potential diagn...

    Zhongyun Chen, Chunyan Liu, Jie Zhang, Norman Relkin, Yan Xing and Yanfeng Li

    Fluids and Barriers of the CNS 2017 14:13

    Published on: 10 May 2017

  16. Review

    NIH workshop report on the trans-agency blood–brain interface workshop 2016: exploring key challenges and opportunities associated with the blood, brain and their interface

    A trans-agency workshop on the blood–brain interface (BBI), sponsored by the National Heart, Lung and Blood Institute, the National Cancer Institute and the Combat Casualty Care Research Program at the Departm...

    Margaret J. Ochocinska, Berislav V. Zlokovic, Peter C. Searson, A. Tamara Crowder, Richard P. Kraig, Julia Y. Ljubimova, Todd G. Mainprize, William A. Banks, Ronald Q. Warren, Andrei Kindzelski, William Timmer and Christina H. Liu

    Fluids and Barriers of the CNS 2017 14:12

    Published on: 1 May 2017

  17. Research

    Cerebrospinal fluid (CSF) biomarkers of iron status are associated with CSF viral load, antiretroviral therapy, and demographic factors in HIV-infected adults

    HIV-associated neurocognitive disorder (HAND) remains common, despite antiretroviral therapy (ART). HIV dysregulates iron metabolism, but cerebrospinal fluid (CSF) levels of iron and iron-transport proteins in...

    Stephanie M. Patton, Quan Wang, Todd Hulgan, James R. Connor, Peilin Jia, Zhongming Zhao, Scott L. Letendre, Ronald J. Ellis, William S. Bush, David C. Samuels, Donald R. Franklin, Harpreet Kaur, Jennifer Iudicello, Igor Grant and Asha R. Kallianpur

    Fluids and Barriers of the CNS 2017 14:11

    Published on: 21 April 2017

  18. Short Paper

    Frontotemporal dementia as a comorbidity to idiopathic normal pressure hydrocephalus (iNPH): a short review of literature and an unusual case

    Behavioural variant frontotemporal dementia (bvFTD) and idiopathic normal pressure hydrocephalus (iNPH) are neurodegenerative diseases that can present with similar symptoms. These include decline in executive...

    V. E. Korhonen, E. Solje, N. M. Suhonen, T. Rauramaa, R. Vanninen, A. M. Remes and V. Leinonen

    Fluids and Barriers of the CNS 2017 14:10

    Published on: 19 April 2017

  19. Research

    Accelerated differentiation of human induced pluripotent stem cells to blood–brain barrier endothelial cells

    Due to their ability to limitlessly proliferate and specialize into almost any cell type, human induced pluripotent stem cells (iPSCs) offer an unprecedented opportunity to generate human brain microvascular e...

    Emma K. Hollmann, Amanda K. Bailey, Archit V. Potharazu, M. Diana Neely, Aaron B. Bowman and Ethan S. Lippmann

    Fluids and Barriers of the CNS 2017 14:9

    Published on: 13 April 2017

  20. Research

    Cerebrospinal fluid abnormalities in meningeosis neoplastica: a retrospective 12-year analysis

    Meningeosis neoplastica is a diffuse metastatic spread of tumor cells in the subarachnoid space. Although first recognized in 1870, systematic investigations regarding cerebrospinal fluid (CSF) constituents in...

    Marija Djukic, Ralf Trimmel, Ingelore Nagel, Annette Spreer, Peter Lange, Christine Stadelmann and Roland Nau

    Fluids and Barriers of the CNS 2017 14:7

    Published on: 28 March 2017

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