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  1. CNS vasculature differs from vascular networks of peripheral organs by its ability to tightly control selective material exchange across capillary barriers. Capillary permeability is mostly defined by unique c...

    Authors: Batia Bell, Shira Anzi, Esther Sasson and Ayal Ben-Zvi
    Citation: Fluids and Barriers of the CNS 2023 20:51
    Content type: Research Published on:

  2. The functions and protein expressions of the blood–brain barrier are changed throughout brain development following birth. This study aimed to develop a method to isolate brain capillaries from a single frozen...

    Authors: Yudai Hamada, Seiryo Ogata, Takeshi Masuda, Shingo Ito and Sumio Ohtsuki
    Citation: Fluids and Barriers of the CNS 2023 20:50
    Content type: Research Published on:

  3. It is crucial to maintain the intracranial pressure (ICP) within the physiological range to ensure proper brain function. The ICP may fluctuate during the light-dark phase cycle, complicating diagnosis and tre...

    Authors: Annette Buur Steffensen, Beatriche Louise Edelbo, Dagne Barbuskaite, Søren Norge Andreassen, Markus Harboe Olsen, Kirsten Møller and Nanna MacAulay
    Citation: Fluids and Barriers of the CNS 2023 20:49
    Content type: Research Published on:

  5. Reduced folate carrier 1 (RFC1; SLC19a1) is the main responsible transporter for the B9 family of vitamins named folates, which are essential for normal tissue growth and development. While folate deficiency r...

    Authors: Gokce Gurler, Nevin Belder, Mustafa Caglar Beker, Melike Sever-Bahcekapili, Gokhan Uruk, Ertugrul Kilic and Muge Yemisci
    Citation: Fluids and Barriers of the CNS 2023 20:47
    Content type: Research Published on:

  6. Focused ultrasound (FUS)-mediated blood–brain barrier (BBB) opening is under investigation as a therapeutic modality for neurodegeneration, yet its effects in humans are incompletely understood. Here, we asses...

    Authors: Rashi I. Mehta, Jeffrey S. Carpenter, Rupal I. Mehta, Marc W. Haut, Peng Wang, Manish Ranjan, Umer Najib, Pierre-François D’Haese and Ali R. Rezai
    Citation: Fluids and Barriers of the CNS 2023 20:46
    Content type: Research Published on:

  7. Regulation of the volume and electrolyte composition of the cerebrospinal fluid (CSF) is vital for brain development and function. The Na-K-Cl co-transporter NKCC1 in the choroid plexus (ChP) plays key roles i...

    Authors: Ryann M. Fame, Huixin Xu, Aja Pragana and Maria Lehtinen
    Citation: Fluids and Barriers of the CNS 2023 20:45
    Content type: Brief Report Published on:

  8. Idiopathic intracranial hypertension (IIH) is a condition characterized by increased intracranial pressure (ICP), impaired vision, and headache. Most cases of IIH occur in obese women of childbearing age, thou...

    Authors: Jonathan H. Wardman, Mette N. Jensen, Søren N. Andreassen, Bjarne Styrishave, Jens E. Wilhjelm, Alexandra J. Sinclair and Nanna MacAulay
    Citation: Fluids and Barriers of the CNS 2023 20:44
    Content type: Research Published on:

  9. Despite recent attention, pathways and mechanisms of fluid transposition in the brain are still a matter of intense discussion and driving forces underlying waste clearance in the brain remain elusive. Consens...

    Authors: Martin Segeroth, Lydia Wachsmuth, Mathias Gagel, Franziska Albers, Andreas Hess and Cornelius Faber
    Citation: Fluids and Barriers of the CNS 2023 20:43
    Content type: Research Published on:

  10. Neonatal hydrocephalus is a congenital abnormality resulting in an inflammatory response and microglial cell activation both clinically and in animal models. Previously, we reported a mutation in a motile cili...

    Authors: Farrah N. Brown, Eri Iwasawa, Crystal Shula, Elizabeth M. Fugate, Diana M. Lindquist, Francesco T. Mangano and June Goto
    Citation: Fluids and Barriers of the CNS 2023 20:42
    Content type: Research Published on:

  12. Idiopathic Normal pressure hydrocephalus (iNPH) is a form of adult hydrocephalus that is clinically characterized by progressive gait impairment, cognitive dysfunction, and urinary incontinence. The current st...

    Authors: Sophia Weiner, Antti Junkkari, Mathias Sauer, Antti Luikku, Tuomas Rauramaa, Tarja Kokkola, Sanna-Kaisa Herukka, Kaj Blennow, Henrik Zetterberg, Ville Leinonen and Johan Gobom
    Citation: Fluids and Barriers of the CNS 2023 20:40
    Content type: Research Published on:

  13. The choroid plexus (ChP) has been suggested as an alternative central nervous system (CNS) entry site for CCR6+ Th17 cells during the initiation of experimental autoimmune encephalomyelitis (EAE), an animal model...

    Authors: Ivana Lazarevic, Sasha Soldati, Josephine A. Mapunda, Henriette Rudolph, Maria Rosito, Alex Cardoso de Oliveira, Gaby Enzmann, Hideaki Nishihara, Hiroshi Ishikawa, Tobias Tenenbaum, Horst Schroten and Britta Engelhardt
    Citation: Fluids and Barriers of the CNS 2023 20:39
    Content type: Research Published on:

    The Correction to this article has been published in Fluids and Barriers of the CNS 2023 20:55

  15. The clearance pathways of brain waste products in humans are still under debate in part due to the lack of noninvasive imaging techniques for meningeal lymphatic vessels (mLVs). In this study, we propose a new...

    Authors: Jun-Hee Kim, Roh-Eul Yoo, Seung Hong Choi and Sung-Hong Park
    Citation: Fluids and Barriers of the CNS 2023 20:37
    Content type: Research Published on:

  16. Blood brain barrier (BBB) models in vitro are an important tool to aid in the pre-clinical evaluation and selection of BBB-crossing therapeutics. Stem cell derived BBB models have recently demonstrated a subst...

    Authors: Anna Jezierski, Jez Huang, Arsalan S. Haqqani, Julie Haukenfrers, Ziying Liu, Ewa Baumann, Caroline Sodja, Claudie Charlebois, Christie E. Delaney, Alexandra T. Star, Qing Liu and Danica B. Stanimirovic
    Citation: Fluids and Barriers of the CNS 2023 20:36
    Content type: Research Published on:

  17. Glucocorticoids (GCs) are widely prescribed for a variety of inflammatory diseases, but they are also used to treat raised intracranial pressure (ICP) caused by trauma or oedema. However, it is unclear if GCs ...

    Authors: Connar Stanley James Westgate, Ida Marchen Egerod Israelsen, Christina Kamp-Jensen, Rigmor Højland Jensen and Sajedeh Eftekhari
    Citation: Fluids and Barriers of the CNS 2023 20:35
    Content type: Research Published on:

  19. The frequencies of morbidity and impairment associated with spontaneous intracerebral haemorrhage (ICH) are comparatively high. Blood-brain barrier (BBB) integrity was compromised due to subsequent brain injur...

    Authors: Ling Gao, Li Peng, Prativa Sherchan, Hong Tang, Yu Liu, Jie Xiao, Hui Shi, Yujie Luo, Jiping Tang, John H. Zhang and Ying Xia
    Citation: Fluids and Barriers of the CNS 2023 20:33
    Content type: Research Published on:

  20. Lead (Pb) is a known environmental risk factor in the etiology of Alzheimer’s disease (AD). The existing reports suggest that Pb exposure increases beta-amyloid (Aβ) levels in brain tissues and cerebrospinal f...

    Authors: Luke L. Liu, Xiaoli Shen, Huiying Gu, Gang Zhao, Yansheng Du and Wei Zheng
    Citation: Fluids and Barriers of the CNS 2023 20:32
    Content type: Research Published on:

  21. Blue light is part of the natural light spectrum that emits high energy. Currently, people are frequently exposed to blue light from 3C devices, resulting in a growing incidence of retinopathy. The retinal vas...

    Authors: Yen-Ju Chan, George Hsiao, Wang-Nok Wan, Tsung-Min Yang, Chi-Hao Tsai, Jaw-Jou Kang, Yu-Cheng Lee, Te-Chao Fang, Yu-Wen Cheng and Ching-Hao Li
    Citation: Fluids and Barriers of the CNS 2023 20:31
    Content type: Research Published on:

  22. This aim of this editorial is to highlight progress made in brain barrier and brain fluid research in 2022. It covers studies on the blood-brain, blood-retina and blood-CSF barriers (choroid plexus and meninge...

    Authors: Richard F. Keep, Hazel C. Jones, Mark G. Hamilton and Lester R. Drewes
    Citation: Fluids and Barriers of the CNS 2023 20:30
    Content type: Editorial Published on:

  24. Insulin transport across the blood-brain barrier (BBB) is a highly regulated, saturable process, known to be affected by many peripheral substrates including insulin itself and triglycerides. This is in contra...

    Authors: Van Nguyen, Peter Thomas, Sarah Pemberton, Alice Babin, Cassidy Noonan, Riley Weaver, William A. Banks and Elizabeth M. Rhea
    Citation: Fluids and Barriers of the CNS 2023 20:28
    Content type: Research Published on:

  26. Recent data indicates that cerebrospinal fluid (CSF) dynamics are disturbed after stroke. Our lab has previously shown that intracranial pressure rises dramatically 24 h after experimental stroke and that this...

    Authors: K. E. Warren, K. G. Coupland, R. J. Hood, L. Kang, F. R. Walker and N. J. Spratt
    Citation: Fluids and Barriers of the CNS 2023 20:27
    Content type: Research Published on:

  27. Blood–brain barrier (BBB) dysfunction occurs in many brain diseases, and there is increasing evidence to suggest that it is an early process in dementia which may be exacerbated by peripheral infection. Filter...

    Authors: Yolanda Ohene, William J. Harris, Elizabeth Powell, Nina W. Wycech, Katherine F. Smethers, Samo Lasič, Kieron South, Graham Coutts, Andrew Sharp, Catherine B. Lawrence, Hervé Boutin, Geoff J. M. Parker, Laura M. Parkes and Ben R. Dickie
    Citation: Fluids and Barriers of the CNS 2023 20:25
    Content type: Research Published on:

  28. Oligodendrocyte lineage cells interact with the vasculature in the gray matter. Physical and functional interactions between blood vessels and oligodendrocyte precursor cells play an essential role in both the...

    Authors: Justine S. C. Palhol, Maddalena Balia, Fernando Sánchez-Román Terán, Mélody Labarchède, Etienne Gontier and Arne Battefeld
    Citation: Fluids and Barriers of the CNS 2023 20:24
    Content type: Research Published on:

  29. Despite greatly renewed interest concerning meningeal lymphatic function over recent years, the lymphatic structures of human dura mater have been less characterized. The available information derives exclusiv...

    Authors: César Luis Vera Quesada, Shreyas Balachandra Rao, Reidun Torp and Per Kristian Eide
    Citation: Fluids and Barriers of the CNS 2023 20:23
    Content type: Research Published on:

  30. The CLDN5 gene encodes claudin-5 (CLDN-5) that is expressed in endothelial cells and forms tight junctions which limit the passive diffusions of ions and solutes. The blood–brain barrier (BBB), composed of brain ...

    Authors: Yosuke Hashimoto, Chris Greene, Arnold Munnich and Matthew Campbell
    Citation: Fluids and Barriers of the CNS 2023 20:22
    Content type: Review Published on:

  31. The meninges, formed by dura, arachnoid and pia mater, cover the central nervous system and provide important barrier functions. Located between arachnoid and pia mater, the cerebrospinal fluid (CSF)-filled su...

    Authors: Diego Rossinelli, Hanspeter Esriel Killer, Peter Meyer, Graham Knott, Gilles Fourestey, Vartan Kurtcuoglu, Corina Kohler, Philipp Gruber, Luca Remonda, Albert Neutzner and Jatta Berberat
    Citation: Fluids and Barriers of the CNS 2023 20:21
    Content type: Research Published on:

  32. Astrocyte endfoot processes are believed to cover all micro-vessels in the brain cortex and may play a significant role in fluid and substance transport into and out of the brain parenchyma. Detailed fluid mec...

    Authors: Timo Koch, Vegard Vinje and Kent-André Mardal
    Citation: Fluids and Barriers of the CNS 2023 20:20
    Content type: Research Published on:

    The Correction to this article has been published in Fluids and Barriers of the CNS 2023 20:57

  33. Choroid plexuses (ChPs) are intraventricular structures mainly composed by specialized epithelial cells interconnected by tight junctions that establish the blood-cerebrospinal fluid (CSF) barrier. ChPs are es...

    Authors: Valentina Scarpetta, Felipe Bodaleo, Chiara Salio, Amit Agarwal, Marco Sassoè-Pognetto and Annarita Patrizi
    Citation: Fluids and Barriers of the CNS 2023 20:19
    Content type: Research Published on:

  34. The mechanisms of cerebrospinal fluid (CSF) production by the ventricular choroid plexus (ChP) have not been fully deciphered. One prominent hypothesized mechanism is trans-epithelial water transport mediated ...

    Authors: Pooya Razzaghi Khamesi, Vasileios Charitatos, Eva K. Heerfordt, Nanna MacAulay and Vartan Kurtcuoglu
    Citation: Fluids and Barriers of the CNS 2023 20:18
    Content type: Research Published on:

  35. Electronic nicotine delivery systems (ENDS), also commonly known as electronic cigarettes (e-cigs) are considered in most cases as a safer alternative to tobacco smoking and therefore have become extremely pop...

    Authors: Sabrina Rahman Archie, Ali Ehsan Sifat, Yong Zhang, Heidi Villalba, Sejal Sharma, Saeideh Nozohouri and Thomas J. Abbruscato
    Citation: Fluids and Barriers of the CNS 2023 20:17
    Content type: Research Published on:

  36. In the cerebrospinal fluid (CSF) dynamics, the pulsations of cerebral arteries and brain is considered the main driving force for the reciprocating bidirectional CSF movements. However, measuring these complex...

    Authors: Shigeki Yamada, Shinnosuke Hiratsuka, Tomohiro Otani, Satoshi Ii, Shigeo Wada, Marie Oshima, Kazuhiko Nozaki and Yoshiyuki Watanabe
    Citation: Fluids and Barriers of the CNS 2023 20:16
    Content type: Research Published on:

  37. Hypertriglyceridemia is closely linked to atherosclerosis related inflammatory processes and blood–brain barrier (BBB) dysfunction. Using apolipoprotein B-100 (APOB-100) transgenic mice, an animal model of chr...

    Authors: Beáta Barabási, Lilla Barna, Ana Raquel Santa-Maria, András Harazin, Réka Molnár, András Kincses, Judit P. Vigh, Brigitta Dukay, Miklós Sántha, Melinda E. Tóth, Fruzsina R. Walter, Mária A. Deli and Zsófia Hoyk
    Citation: Fluids and Barriers of the CNS 2023 20:15
    Content type: Research Published on:

  38. Incomplete recovery of blood–brain barrier (BBB) function contributes to stroke outcomes. How the BBB recovers after stroke remains largely unknown. Emerging evidence suggests that epigenetic factors play a si...

    Authors: Chelsea M. Phillips, Svetlana M. Stamatovic, Richard F. Keep and Anuska V. Andjelkovic
    Citation: Fluids and Barriers of the CNS 2023 20:14
    Content type: Research Published on:

  39. Potential biomarkers for neuropsychiatric disorders are cerebrospinal fluid (CSF) monoamines and their corresponding precursors and metabolites. During CSF sampling, CSF flows towards the lumbar sampling site ...

    Authors: Celien Tigchelaar, Willemien D. Muller, Sawal D. Atmosoerodjo, Klaas J. Wardenaar, Ido P. Kema, Anthony R. Absalom and Martijn van Faassen
    Citation: Fluids and Barriers of the CNS 2023 20:13
    Content type: Research Published on:

  40. The three-layered meninges cover and protect the central nervous system and form the interface between cerebrospinal fluid and the brain. They are host to a lymphatic system essential for maintaining fluid dyn...

    Authors: Melanie Neutzner, Corina Kohler, Stephan Frank, Hanspeter E. Killer and Albert Neutzner
    Citation: Fluids and Barriers of the CNS 2023 20:12
    Content type: Research Published on:

  41. Regulation of cerebral blood flow (CBF) directly influence brain functions and dysfunctions and involves complex mechanisms, including neurovascular coupling (NVC). It was suggested that the serine protease ti...

    Authors: Jonathane Furon, Mervé Yetim, Elsa Pouettre, Sara Martinez de Lizarrondo, Eric Maubert, Yannick Hommet, Laurent Lebouvier, Ze Zheng, Carine Ali and Denis Vivien
    Citation: Fluids and Barriers of the CNS 2023 20:11
    Content type: Research Published on:

  42. Brain microvascular endothelial cells (BMECs) play a major role in the blood–brain barrier (BBB), and are critical for establishing an in vitro BBB model. Currently, iPSC-derived BMECs (iBMECs) have been used ...

    Authors: Hongyan Zhang, Tomoko Yamaguchi and Kenji Kawabata
    Citation: Fluids and Barriers of the CNS 2023 20:10
    Content type: Research Published on:

  43. Age-related changes in the cerebrovasculature, including blood–brain barrier (BBB) disruption and vascular dementia, are emerging as potential risks for many neurodegenerative diseases. Therefore, the endothel...

    Authors: Hyejeong Kim, Minyoung Noh, Haiying Zhang, Yeomyeong Kim, Songyi Park, Jeongeun Park and Young-Guen Kwon
    Citation: Fluids and Barriers of the CNS 2023 20:9
    Content type: Research Published on:

  44. The multidrug resistance (MDR) transporters, P-glycoprotein (P-gp, encoded by ABCB1) and breast cancer resistance protein (BCRP/ABCG2) contribute to the blood–brain barrier (BBB), protecting the brain from drug e...

    Authors: Phetcharawan Lye, Enrrico Bloise and Stephen G. Matthews
    Citation: Fluids and Barriers of the CNS 2023 20:8
    Content type: Research Published on:

  45. Idiopathic normal pressure hydrocephalus (iNPH) is a progressive and partially reversible form of dementia, characterized by impaired interactions between multiple brain regions. Because of the presence of com...

    Authors: Sara Fabbro, Daniele Piccolo, Maria Caterina Vescovi, Daniele Bagatto, Yan Tereshko, Enrico Belgrado, Marta Maieron, Maria Cristina De Colle, Miran Skrap and Francesco Tuniz
    Citation: Fluids and Barriers of the CNS 2023 20:7
    Content type: Research Published on:

  46. Pathological cerebral conditions may manifest in altered composition of the cerebrospinal fluid (CSF). Although diagnostic CSF analysis seeks to establish pathological disturbances in the brain proper, CSF is ...

    Authors: Nina Rostgaard, Markus Harboe Olsen, Maud Ottenheijm, Lylia Drici, Anja Hviid Simonsen, Peter Plomgaard, Hanne Gredal, Helle Harding Poulsen, Henrik Zetterberg, Kaj Blennow, Steen Gregers Hasselbalch, Nanna MacAulay and Marianne Juhler
    Citation: Fluids and Barriers of the CNS 2023 20:6
    Content type: Research Published on:

  47. Detecting changes in pulsatile cerebrospinal fluid (CSF) flow may assist clinical management decisions, but spinal CSF flow is relatively understudied. Traumatic spinal cord injuries (SCI) often cause spinal c...

    Authors: Madeleine Amy Bessen, Christine Diana Gayen, Ryan David Quarrington, Angela Catherine Walls, Anna Victoria Leonard, Vartan Kurtcuoglu and Claire Frances Jones
    Citation: Fluids and Barriers of the CNS 2023 20:5
    Content type: Research Published on:

  49. The Hydrocephalus Association (HA) workshop, Driving Common Pathways: Extending Insights from Posthemorrhagic Hydrocephalus, was held on November 4 and 5, 2019 at Washington University in St. Louis. The worksh...

    Authors: Jason K. Karimy, Jessie C. Newville, Cameron Sadegh, Jill A. Morris, Edwin S. Monuki, David D. Limbrick Jr., James P. McAllister II, Jenna E. Koschnitzky, Maria K. Lehtinen and Lauren L. Jantzie
    Citation: Fluids and Barriers of the CNS 2023 20:4
    Content type: Review Published on:

  50. Impaired cerebrospinal fluid (CSF) homeostasis is central to the pathogenesis of idiopathic intracranial hypertension (IIH), although the precise mechanisms involved are still not completely understood. The ai...

    Authors: Sinah Engel, Johannes Halcour, Erik Ellwardt, Timo Uphaus, Falk Steffen, Frauke Zipp, Stefan Bittner and Felix Luessi
    Citation: Fluids and Barriers of the CNS 2023 20:3
    Content type: Research Published on:
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  • ISSN: 2045-8118 (electronic)

Fluids and Barriers of the CNS

ISSN: 2045-8118