Skip to main content

Articles

Page 16 of 26

  1. The function of pericytes remains questionable but with improved cultured technique and the use of genetically modified animals, it has become increasingly clear that pericytes are an integral part of blood–br...

    Authors: Elodie Vandenhaute, Maxime Culot, Fabien Gosselet, Lucie Dehouck, Catherine Godfraind, Michel Franck, Jean Plouët, Roméo Cecchelli, Marie-Pierre Dehouck and Marie-Magdeleine Ruchoux
    Citation: Fluids and Barriers of the CNS 2012 9:11
    Content type: Research Published on:

  2. Choroid plexus epithelial cells are the site of blood/cerebrospinal fluid (CSF) barrier and regulate molecular transfer between the two compartments. Their mitotic activity in the adult is low. During developm...

    Authors: Shane A Liddelow, Katarzyna M Dziegielewska, John L VandeBerg and Norman R Saunders
    Citation: Cerebrospinal Fluid Research 2010 7:16
    Content type: Research Published on:

  3. The water channel protein aquaporin-4 (AQP4) is reported to be of possible major importance for accessory cerebrospinal fluid (CSF) circulation pathways. We hypothesized that changes in AQP4 expression in spec...

    Authors: Anders D Skjolding, Ian J Rowland, Lise V Søgaard, Jeppe Praetorius, Milena Penkowa and Marianne Juhler
    Citation: Cerebrospinal Fluid Research 2010 7:20
    Content type: Research Published on:

  4. C-X-C chemokine ligand 13 (CXCL13) is frequently elevated in cerebrospinal fluid (CSF) in a variety of inflammatory central nervous system (CNS) diseases, has been detected in meningeal B cell aggregates in br...

    Authors: Christine Harrer, Ferdinand Otto, Georg Pilz, Elisabeth Haschke-Becher, Eugen Trinka, Wolfgang Hitzl, Peter Wipfler and Andrea Harrer
    Citation: Fluids and Barriers of the CNS 2021 18:40
    Content type: Research Published on:

  5. Despite the great potential of FUS-BBB disruption (FUS-BBBD), it is still controversial whether FUS-BBBD acts as an inducing factor of neuro-inflammation or not, and the biological responses after FUS-BBBD tri...

    Authors: Hyo Jin Choi, Mun Han, Hyeon Seo, Chan Yuk Park, Eun-Hee Lee and Juyoung Park
    Citation: Fluids and Barriers of the CNS 2022 19:103
    Content type: Research Published on:

  7. Parenchymal accumulation of beta-amyloid (Aβ) characterizes Alzheimer’s disease (AD). Aβ homeostasis is maintained by two ATP-binding cassette (ABC) transporters (ABCC1 and ABCB1) mediating efflux, and the rec...

    Authors: Amira Sayed Hanafy, Alf Lamprecht and Dirk Dietrich
    Citation: Fluids and Barriers of the CNS 2023 20:85
    Content type: Research Published on:

  10. In hydrocephalus an imbalance between production and absorption of cerebrospinal fluid (CSF) results in fluid accumulation, compression and stretching of the brain parenchyma. In addition, changes in CSF compo...

    Authors: Irum Naureen, Khawaja AIrfan Waheed, Ahsen W Rathore, Suresh Victor, Conor Mallucci, John R Goodden, Shahid N Chohan and Jaleel A Miyan
    Citation: Fluids and Barriers of the CNS 2013 10:34
    Content type: Research Published on:

  12. In recent years, differentiation of human induced pluripotent stem cells (hiPSCs) into brain-specific microvascular endothelial cells (iBMECs) has frequently been used to model the blood–brain barrier (BBB). H...

    Authors: Pedram Motallebnejad and Samira M. Azarin
    Citation: Fluids and Barriers of the CNS 2020 17:54
    Content type: Research Published on:

  13. Adenylyl cyclases (ADCYs), by generating second messenger cAMP, play important roles in various cellular processes. Their expression, regulation and functions in the CNS, however, remain largely unknown. In th...

    Authors: Karan Devasani and Yao Yao
    Citation: Fluids and Barriers of the CNS 2022 19:23
    Content type: Review Published on:

  14. Idiopathic normal pressure hydrocephalus (iNPH) is a potentially reversible cause of dementia and gait disturbance that is typically treated by operative placement of a ventriculoperitoneal shunt. The outcome ...

    Authors: Sunil Patel, Edward B Lee, Sharon X Xie, Anica Law, Eric M Jackson, Steven E Arnold, Christopher M Clark, Leslie M Shaw, M Sean Grady, John Q Trojanowski and Roy H Hamilton
    Citation: Fluids and Barriers of the CNS 2012 9:7
    Content type: Research Published on:

  15. Idiopathic intracranial hypertension (IIH) is a condition characterized by increased intracranial pressure (ICP), impaired vision, and headache. Most cases of IIH occur in obese women of childbearing age, thou...

    Authors: Jonathan H. Wardman, Mette N. Jensen, Søren N. Andreassen, Bjarne Styrishave, Jens E. Wilhjelm, Alexandra J. Sinclair and Nanna MacAulay
    Citation: Fluids and Barriers of the CNS 2023 20:44
    Content type: Research Published on:

  16. Parkinson’s disease is characterized by dopamine-responsive symptoms as well as aggregation of α-synuclein protofibrils. New diagnostic methods assess α-synuclein aggregation characteristics from cerebrospinal...

    Authors: Gabriela Pierobon Mays, Kilian Hett, Jarrod Eisma, Colin D. McKnight, Jason Elenberger, Alexander K. Song, Ciaran Considine, Wesley T. Richerson, Caleb Han, Adam Stark, Daniel O. Claassen and Manus J. Donahue
    Citation: Fluids and Barriers of the CNS 2024 21:40
    Content type: Research Published on:

  17. Idiopathic normal pressure hydrocephalus (iNPH) is a neurological condition with gait apraxia signs from its early manifestation. Ventriculoperitoneal shunt (VPS) is a surgical procedure available for treatmen...

    Authors: Alberto Ferrari, David Milletti, Pierpaolo Palumbo, Giulia Giannini, Sabina Cevoli, Elena Magelli, Luca Albini-Riccioli, Paolo Mantovani, Pietro Cortelli, Lorenzo Chiari and Giorgio Palandri
    Citation: Fluids and Barriers of the CNS 2022 19:51
    Content type: Research Published on:

  18. Mounting evidence suggests that the blood-brain barrier (BBB) plays an important role in the regulation of brain iron homeostasis in normal brain development, but these imaging profiles remain to be elucidated...

    Authors: Yuto Uchida, Hirohito Kan, Gen Furukawa, Kengo Onda, Keita Sakurai, Koji Takada, Noriyuki Matsukawa and Kenichi Oishi
    Citation: Fluids and Barriers of the CNS 2023 20:60
    Content type: Research Published on:

  19. This editorial discusses advances in brain barrier and brain fluid research in 2020. Topics include: the cerebral endothelium and the neurovascular unit; the choroid plexus; the meninges; cerebrospinal fluid a...

    Authors: Richard F. Keep, Hazel C. Jones and Lester R. Drewes
    Citation: Fluids and Barriers of the CNS 2021 18:24
    Content type: Editorial Published on:

  21. Idiopathic normal pressure hydrocephalus (iNPH) is a treatable neurological syndrome in the elderly. Although the magnetic resonance imaging (MRI) findings of tight high-convexity and medial subarachnoid space...

    Authors: Masaaki Hashimoto, Masatsune Ishikawa, Etsuro Mori and Nobumasa Kuwana
    Citation: Cerebrospinal Fluid Research 2010 7:18
    Content type: Research Published on:

  22. The administration of microbial neuraminidase into the brain ventricular cavities of rodents represents a model of acute aseptic neuroinflammation. Ependymal cell death and hydrocephalus are unique features of...

    Authors: María del Mar Fernández-Arjona, Ana León-Rodríguez, María Dolores López-Ávalos and Jesús M. Grondona
    Citation: Fluids and Barriers of the CNS 2021 18:15
    Content type: Research Published on:

  23. Infectious and immunological theories of schizophrenia have been discussed for over a century. Contradictory results for infectious agents in association with schizophrenia spectrum disorders (SSDs) were repor...

    Authors: Kimon Runge, Agnes Balla, Bernd L. Fiebich, Simon J. Maier, Benjamin Pankratz, Andrea Schlump, Kathrin Nickel, Rick Dersch, Katharina Domschke, Ludger Tebartz van Elst and Dominique Endres
    Citation: Fluids and Barriers of the CNS 2022 19:61
    Content type: Research Published on:

  24. Repetitive transient intracranial pressure waveform elevations up to 50 mmHg (ICP B-waves) are often used to define pathological conditions and determine indications for ICP-reducing treatment. We recently sho...

    Authors: Casper Schwartz Riedel, Isabel Martinez-Tejada, Morten Andresen, Jens E. Wilhjelm, Poul Jennum and Marianne Juhler
    Citation: Fluids and Barriers of the CNS 2023 20:69
    Content type: Research Published on:

  25. Cerebrospinal fluid is a clear fluid that occupies the ventricular and subarachnoid spaces within and around the brain and spinal cord. Cerebrospinal fluid is a dynamic signaling milieu that transports nutrien...

    Authors: Vania Sepúlveda, Felipe Maurelia, Maryori González, Jaime Aguayo and Teresa Caprile
    Citation: Fluids and Barriers of the CNS 2021 18:45
    Content type: Review Published on:

  26. Syringomyelia (SM) is characterized by the development of fluid-filled cavities, referred to as syrinxes, within the spinal cord tissue. The molecular etiology of SM post-spinal cord injury (SCI) is not well u...

    Authors: Dipak D. Pukale, Kayla Adkins-Travis, Siddhartha R. Aryal, Leah P. Shriver, Gary J. Patti and Nic D. Leipzig
    Citation: Fluids and Barriers of the CNS 2024 21:19
    Content type: Research Published on:

  27. The blood brain barrier (BBB) limits the therapeutic perspective for central nervous system (CNS) disorders. Previously we found an anti-mouse transferrin receptor (TfR) VHH (Nb62) that was able to deliver a b...

    Authors: Yessica Wouters, Tom Jaspers, Laura Rué, Lutgarde Serneels, Bart De Strooper and Maarten Dewilde
    Citation: Fluids and Barriers of the CNS 2022 19:79
    Content type: Research Published on:

  29. Autoreactive T lymphocytes crossing the blood-brain barrier (BBB) into the central nervous system (CNS) play a crucial role in the initiation of demyelination and neurodegeneration in multiple sclerosis (MS). ...

    Authors: Baharak Hosseinkhani, Gayel Duran, Cindy Hoeks, Doryssa Hermans, Melissa Schepers, Paulien Baeten, Joren Poelmans, Britt Coenen, Kübra Bekar, Isabel Pintelon, Jean-Pierre Timmermans, Tim Vanmierlo, Luc Michiels, Niels Hellings and Bieke Broux
    Citation: Fluids and Barriers of the CNS 2023 20:95
    Content type: Research Published on:

  32. Chemotherapy-induced peripheral neuropathy (CIPN) represents a major unmet medical need that currently has no preventive and/or curative treatment. This is, among others, driven by a poor understanding of the ...

    Authors: Yang Hu, Milda Girdenyté, Lieke Roest, Iida Liukkonen, Maria Siskou, Frida Bällgren, Margareta Hammarlund-Udenaes and Irena Loryan
    Citation: Fluids and Barriers of the CNS 2024 21:13
    Content type: Research Published on:

  33. Oxidative stress is a shared pathology of neurodegenerative disease and brain injuries, and is derived from perturbations to normal cell processes by aging or environmental factors such as UV exposure and air ...

    Authors: Tracy D. Chung, Raleigh M. Linville, Zhaobin Guo, Robert Ye, Ria Jha, Gabrielle N. Grifno and Peter C. Searson
    Citation: Fluids and Barriers of the CNS 2022 19:33
    Content type: Research Published on:

  34. Hydrocephalus is characterized by abnormal accumulation of cerebrospinal fluid in the cerebral ventricles and causes motor impairments. The mechanisms underlying the motor changes remain elusive. Enlargement o...

    Authors: Li-Jin Chen, Jeng-Rung Chen and Guo-Fang Tseng
    Citation: Fluids and Barriers of the CNS 2022 19:95
    Content type: Research Published on:

  35. This article reviews current knowledge of the mechanisms underlying the initial hemorrhage and secondary blood–brain barrier (BBB) dysfunction in primary spontaneous intracerebral hemorrhage (ICH) in adults. M...

    Authors: Richard F Keep, Ningna Zhou, Jianming Xiang, Anuska V Andjelkovic, Ya Hua and Guohua Xi
    Citation: Fluids and Barriers of the CNS 2014 11:18
    Content type: Review Published on:

  36. Proper neuronal function is directly dependent on the composition, turnover, and amount of interstitial fluid that bathes the cells. Most of the interstitial fluid is likely to be derived from ion and water tr...

    Authors: Daphne M. P. Naessens, Bram F. Coolen, Judith de Vos, Ed VanBavel, Gustav J. Strijkers and Erik N. T. P. Bakker
    Citation: Fluids and Barriers of the CNS 2020 17:41
    Content type: Research Published on:

  37. Neuroimmune communication contributes to both baseline and adaptive physiological functions, as well as disease states. The vascular blood–brain barrier (BBB) and associated cells of the neurovascular unit (NV...

    Authors: Michelle A. Erickson, Miranda L. Wilson and William A. Banks
    Citation: Fluids and Barriers of the CNS 2020 17:26
    Content type: Review Published on:

  38. Cerebrospinal fluid (CSF) circulation in the brain has garnered considerable attention in recent times. In contrast, there have been fewer studies focused on the spine, despite the expected importance of CSF c...

    Authors: Shinuo Liu, Lynne E. Bilston, Neftali Flores Rodriguez, Courtney Wright, Simon McMullan, Robert Lloyd, Marcus A. Stoodley and Sarah J. Hemley
    Citation: Fluids and Barriers of the CNS 2022 19:14
    Content type: Research Published on:

  39. A tool for standardized and repeated neuropsychological assessments in patients with idiopathic normal pressure hydrocephalus (INPH) is needed. The objective of this study was to develop a computerized neurops...

    Authors: Anders Behrens, Anders Eklund, Eva Elgh, Cynthia Smith, Michael A Williams and Jan Malm
    Citation: Fluids and Barriers of the CNS 2014 11:22
    Content type: Research Published on:

  40. The CLDN5 gene encodes claudin-5 (CLDN-5) that is expressed in endothelial cells and forms tight junctions which limit the passive diffusions of ions and solutes. The blood–brain barrier (BBB), composed of brain ...

    Authors: Yosuke Hashimoto, Chris Greene, Arnold Munnich and Matthew Campbell
    Citation: Fluids and Barriers of the CNS 2023 20:22
    Content type: Review Published on:

  42. Intraventricular hemorrhage (IVH) and associated hydrocephalus are significant complications of intracerebral and subarachnoid hemorrhage. Despite proximity to IVH, the immune cell response at the choroid plex...

    Authors: Yingfeng Wan, Xiongjie Fu, Tianjie Zhang, Ya Hua, Richard F. Keep and Guohua Xi
    Citation: Fluids and Barriers of the CNS 2024 21:37
    Content type: Research Published on:

  43. There is increasing awareness that, aside from producing cerebrospinal fluid, the choroid plexus (CP) might be a key regulator of immune activity in the central nervous system (CNS) during neuroinflammation. S...

    Authors: Nivetha Murugesan, Debayon Paul, Yen Lemire, Bandana Shrestha, Shujun Ge and Joel S Pachter
    Citation: Fluids and Barriers of the CNS 2012 9:15
    Content type: Research Published on:

  45. Despite recent attention, pathways and mechanisms of fluid transposition in the brain are still a matter of intense discussion and driving forces underlying waste clearance in the brain remain elusive. Consens...

    Authors: Martin Segeroth, Lydia Wachsmuth, Mathias Gagel, Franziska Albers, Andreas Hess and Cornelius Faber
    Citation: Fluids and Barriers of the CNS 2023 20:43
    Content type: Research Published on:

  46. Approximately 30% of cerebrospinal fluid (CSF) shunt systems for hydrocephalus fail within the first year and 98% of all patients will have shunt failure in their lifetime. Obstruction remains the most common ...

    Authors: Carolyn A. Harris, Diego M. Morales, Rooshan Arshad, James P. McAllister II and David D. Limbrick Jr
    Citation: Fluids and Barriers of the CNS 2021 18:4
    Content type: Research Published on:

  47. The function of the blood-brain barrier (BBB) is impaired in late-onset Alzheimer disease (LOAD), but the associated molecular mechanisms, particularly with respect to the high-risk APOE4/4 genotype, are not w...

    Authors: Undine Haferkamp, Carla Hartmann, Chaudhry Luqman Abid, Andreas Brachner, Alevtina Höchner, Anna Gerhartl, Bernadette Harwardt, Selin Leckzik, Jennifer Leu, Marco Metzger, Marina Nastainczyk-Wulf, Winfried Neuhaus, Sabrina Oerter, Ole Pless, Dan Rujescu, Matthias Jung…
    Citation: Fluids and Barriers of the CNS 2023 20:78
    Content type: Research Published on:

  48. Cerebrospinal fluid (CSF) is mainly produced by the choroid plexus (CP) located in brain ventricles. Although derived from blood plasma, it is nearly protein-free (~ 250-fold less) and contains about 2–20-fold...

    Authors: Elena Dolgodilina, Simone M. Camargo, Eva Roth, Brigitte Herzog, Virginia Nunes, Manuel Palacín and Francois Verrey
    Citation: Fluids and Barriers of the CNS 2020 17:17
    Content type: Research Published on:

  49. Bacterial meningitis is a life-threatening disease that occurs when pathogens such as Neisseria meningitidis cross the meningeal blood cerebrospinal fluid barrier (mBCSFB) and infect the meninges. Due to the huma...

    Authors: Leo M. Endres, Marvin Jungblut, Mustafa Divyapicigil, Markus Sauer, Christian Stigloher, Myron Christodoulides, Brandon J. Kim and Alexandra Schubert-Unkmeir
    Citation: Fluids and Barriers of the CNS 2022 19:81
    Content type: Research Published on:

  50. Idiopathic normal pressure hydrocephalus (iNPH) is a reversible CNS disease characterized by disturbed cerebrospinal fluid (CSF) dynamics. Changes in the extracellular matrix (ECM) composition might be involve...

    Authors: Karolina Minta, Anna Jeppsson, Gunnar Brinkmalm, Erik Portelius, Henrik Zetterberg, Kaj Blennow, Mats Tullberg and Ulf Andreasson
    Citation: Fluids and Barriers of the CNS 2021 18:23
    Content type: Research Published on:
Submit manuscript
  • ISSN: 2045-8118 (electronic)

Fluids and Barriers of the CNS

ISSN: 2045-8118