Skip to main content

Articles

Page 15 of 26

  1. Knowledge of the molecular basis and transport function of the human blood–brain barrier (BBB) is important for not only understanding human cerebral physiology, but also development of new central nervous sys...

    Authors: Keita Shimomura, Takashi Okura, Sayaka Kato, Pierre-Olivier Couraud, Jean-Michel Schermann, Tetsuya Terasaki and Yoshiharu Deguchi
    Citation: Fluids and Barriers of the CNS 2013 10:8
    Content type: Research Published on:

  2. Incomplete recovery of blood–brain barrier (BBB) function contributes to stroke outcomes. How the BBB recovers after stroke remains largely unknown. Emerging evidence suggests that epigenetic factors play a si...

    Authors: Chelsea M. Phillips, Svetlana M. Stamatovic, Richard F. Keep and Anuska V. Andjelkovic
    Citation: Fluids and Barriers of the CNS 2023 20:14
    Content type: Research Published on:

  3. The pia arachnoid complex (PAC) is a cerebrospinal fluid-filled tissue conglomerate that surrounds the brain and spinal cord. Pia mater adheres directly to the surface of the brain while the arachnoid mater ad...

    Authors: Gabryel Conley Natividad, Sophia K. Theodossiou, Nathan R. Schiele, Gordon K. Murdoch, Alkiviadis Tsamis, Bertrand Tanner, Gabriel Potirniche, Martin Mortazavi, David A. Vorp and Bryn A. Martin
    Citation: Fluids and Barriers of the CNS 2020 17:68
    Content type: Research Published on:

  4. The blood-brain barrier (BBB) serves as a highly intricate and dynamic interface connecting the brain and the bloodstream, playing a vital role in maintaining brain homeostasis. BBB dysfunction has been associ...

    Authors: Ana Aragón-González, Allan C Shaw, Jannigje R Kok, Florence S Roussel, Cleide dos Santos Souza, Sarah M Granger, Tatyana Vetter, Yolanda de Diego, Kathrin C Meyer, Selina N Beal, Pamela J Shaw and Laura Ferraiuolo
    Citation: Fluids and Barriers of the CNS 2024 21:34
    Content type: Research Published on:

  5. Cerebral infarction accounts for 85% of all stroke cases. Even in an era of rapid and effective recanalization using an intravascular approach, the majority of patients have poor functional outcomes. Thus, the...

    Authors: Kei Sato, Shinsuke Nakagawa, Yoichi Morofuji, Yuki Matsunaga, Takashi Fujimoto, Daisuke Watanabe, Tsuyoshi Izumo, Masami Niwa, Fruzsina R. Walter, Judit P. Vigh, Ana Raquel Santa-Maria, Maria A. Deli and Takayuki Matsuo
    Citation: Fluids and Barriers of the CNS 2022 19:43
    Content type: Research Published on:

  7. Age is the major risk factor for many neurodegenerative diseases, including Alzheimer's disease (AD). There is an accumulation of amyloid-beta peptides (Aβ) in both the AD brain and the normal aging brain. Cle...

    Authors: Crissey L Pascale, Miles C Miller, Catherine Chiu, Matthew Boylan, Ilias N Caralopoulos, Liliana Gonzalez, Conrad E Johanson and Gerald D Silverberg
    Citation: Fluids and Barriers of the CNS 2011 8:21
    Content type: Research Published on:

  8. Predictive in vitro models of the human blood–brain barrier (BBB) are essential in early drug discovery and development. Among available immortalized human brain capillary endothelial cell lines (BCECs), the h...

    Authors: Birthe Gericke, Kerstin Römermann, Andreas Noack, Sandra Noack, Jessica Kronenberg, Ingolf Ernst Blasig and Wolfgang Löscher
    Citation: Fluids and Barriers of the CNS 2020 17:53
    Content type: Research Published on:

  9. The choroid plexus (CP) forming the blood–cerebrospinal fluid (B-CSF) barrier is among the least studied structures of the central nervous system (CNS) despite its clinical importance. The CP is an epithelio-e...

    Authors: Peter Solár, Alemeh Zamani, Lucie Kubíčková, Petr Dubový and Marek Joukal
    Citation: Fluids and Barriers of the CNS 2020 17:35
    Content type: Review Published on:

  10. According to the traditional understanding of cerebrospinal fluid (CSF) physiology, the majority of CSF is produced by the choroid plexus, circulates through the ventricles, the cisterns, and the subarachnoid ...

    Authors: Thomas Brinker, Edward Stopa, John Morrison and Petra Klinge
    Citation: Fluids and Barriers of the CNS 2014 11:10
    Content type: Review Published on:

  12. Neonatal hydrocephalus is a congenital abnormality resulting in an inflammatory response and microglial cell activation both clinically and in animal models. Previously, we reported a mutation in a motile cili...

    Authors: Farrah N. Brown, Eri Iwasawa, Crystal Shula, Elizabeth M. Fugate, Diana M. Lindquist, Francesco T. Mangano and June Goto
    Citation: Fluids and Barriers of the CNS 2023 20:42
    Content type: Research Published on:

  14. Blast-induced traumatic brain injury (bTBI) is a growing health concern due to the increased use of low-cost improvised explosive devices in modern warfare. Mild blast exposures are common amongst military per...

    Authors: Gozde Uzunalli, Seth Herr, Alexandra M. Dieterly, Riyi Shi and L. Tiffany Lyle
    Citation: Fluids and Barriers of the CNS 2021 18:2
    Content type: Research Published on:

  15. Phase contrast magnetic resonance imaging, PC MRI, is a valuable tool allowing for non-invasive quantification of CSF dynamics, but has lacked adoption in clinical practice for Chiari malformation diagnostics....

    Authors: Gwendolyn Williams, Suraj Thyagaraj, Audrey Fu, John Oshinski, Daniel Giese, Alexander C. Bunck, Eleonora Fornari, Francesco Santini, Mark Luciano, Francis Loth and Bryn A. Martin
    Citation: Fluids and Barriers of the CNS 2021 18:12
    Content type: Research Published on:

  16. Here, we report an experimental setup to benchmark different receptors for targeted therapeutic antibody delivery at the blood–brain barrier. We used brain capillary endothelial-like cells derived from induced...

    Authors: Mikkel Roland Holst, Nienke Marije de Wit, Burak Ozgür, Andreas Brachner, Kathrine Hyldig, Antje Appelt-Menzel, Hannah Sleven, Zameel Cader, Helga Eveline de Vries, Winfried Neuhaus, Allan Jensen, Birger Brodin and Morten Schallburg Nielsen
    Citation: Fluids and Barriers of the CNS 2023 20:82
    Content type: Research Published on:

  17. Blood–brain barrier (BBB) dysfunction is supposed to be an early event in the development of Alzheimer’s disease (AD). This study aimed to investigate the relationship between BBB alterations and AD progressio...

    Authors: Shingo Ito, Ryotaro Yagi, Seiryo Ogata, Takeshi Masuda, Takashi Saito, Takaomi Saido and Sumio Ohtsuki
    Citation: Fluids and Barriers of the CNS 2023 20:66
    Content type: Research Published on:

  19. Cerebrospinal fluid (CSF) is an ultra-filtrated colorless brain fluid that circulates within brain spaces like the ventricular cavities, subarachnoid space, and the spine. Its continuous flow serves many prima...

    Authors: Vijay Kumar, Zobia Umair, Shiv Kumar, Ravi Shankar Goutam, Soochul Park and Jaebong Kim
    Citation: Fluids and Barriers of the CNS 2021 18:31
    Content type: Review Published on:

  20. The short and long-term health effects of JUUL electronic cigarette (e-Cig) are largely unknown and warrant extensive research. We hypothesized that JUUL exposure could cause cerebrovascular toxicities impacti...

    Authors: Ali Ehsan Sifat, Sabrina Rahman Archie, Saeideh Nozohouri, Heidi Villalba, Yong Zhang, Sejal Sharma, Yashwardhan Ghanwatkar, Bhuvaneshwar Vaidya, David Mara, Luca Cucullo and Thomas J. Abbruscato
    Citation: Fluids and Barriers of the CNS 2022 19:74
    Content type: Research Published on:

  21. The mechanisms behind formation and filling of intracranial arachnoid cysts (AC) are poorly understood. The aim of this study was to evaluate AC fluid by proteomics to gain further knowledge about ACs. Two goa...

    Authors: Magnus Berle, Ann C Kroksveen, Øystein A Haaland, Thin T Aye, Jill A Opsahl, Eystein Oveland, Knut Wester, Rune J Ulvik, Christian A Helland and Frode S Berven
    Citation: Fluids and Barriers of the CNS 2011 8:19
    Content type: Research Published on:

  22. AhR activates the transcription of several target genes including CYP1B1. Recently, we showed CYP1B1 as the major cytochrome P450 (CYP) enzyme expressed in human brain microvessels. Here, we studied the effect of...

    Authors: Aude Jacob, Anika MS Hartz, Sophie Potin, Xavier Coumoul, Salah Yousif, Jean-Michel Scherrmann, Björn Bauer and Xavier Declèves
    Citation: Fluids and Barriers of the CNS 2011 8:23
    Content type: Research Published on:

  23. Blood-brain barrier (BBB) models based on primary murine, bovine, and porcine brain capillary endothelial cell cultures have long been regarded as robust models with appropriate properties to examine the funct...

    Authors: Burak Ozgür, Elena Puris, Andreas Brachner, Antje Appelt-Menzel, Sabrina Oerter, Viktor Balzer, Mikkel Roland Holst, Rasmus Folmann Christiansen, Kathrine Hyldig, Stephen T. Buckley, Mie Kristensen, Seppo Auriola, Allan Jensen, Gert Fricker, Morten Schallburg Nielsen, Winfried Neuhaus…
    Citation: Fluids and Barriers of the CNS 2023 20:96
    Content type: Research Published on:

  24. Most investigations into postural influences on craniospinal and adjacent physiology have been performed in anesthetized animals. A comprehensive study evaluating these physiologies while awake has yet been co...

    Authors: Anthony Podgoršak, Nina Eva Trimmel, Markus Florian Oertel, Margarete Arras, Miriam Weisskopf and Marianne Schmid Daners
    Citation: Fluids and Barriers of the CNS 2023 20:83
    Content type: Research Published on:

  26. Disruption of cerebrospinal fluid (CSF)/interstitial fluid (ISF) exchange in the spinal cord is likely to contribute to central nervous system (CNS) diseases that involve abnormal fluid accumulation, including...

    Authors: Shinuo Liu, Lynne E. Bilston, Marcus A. Stoodley and Sarah J. Hemley
    Citation: Fluids and Barriers of the CNS 2021 18:47
    Content type: Research Published on:

  27. Reduced clearance of cerebrospinal fluid (CSF) has been suggested as a pathological feature of Alzheimer’s disease (AD). With extensive documentation in non-human mammals and contradictory human neuroimaging d...

    Authors: Neel H. Mehta, Xiuyuan Wang, Samantha A. Keil, Ke Xi, Liangdong Zhou, Kevin Lee, Wanbin Tan, Edward Spector, Amirhossein Goldan, James Kelly, Nicolas A. Karakatsanis, P. David Mozley, Sadek Nehmeh, J. Levi Chazen, Simon Morin, John Babich…
    Citation: Fluids and Barriers of the CNS 2024 21:30
    Content type: Research Published on:

  28. Many aspects of CSF dynamics are poorly understood due to the difficulties involved in quantification and visualization. In particular, there is debate surrounding the route of CSF drainage. Our aim was to qua...

    Authors: Lucy A Murtha, Qing Yang, Mark W Parsons, Christopher R Levi, Daniel J Beard, Neil J Spratt and Damian D McLeod
    Citation: Fluids and Barriers of the CNS 2014 11:12
    Content type: Research Published on:

  29. Regulation of the volume and electrolyte composition of the cerebrospinal fluid (CSF) is vital for brain development and function. The Na-K-Cl co-transporter NKCC1 in the choroid plexus (ChP) plays key roles i...

    Authors: Ryann M. Fame, Huixin Xu, Aja Pragana and Maria Lehtinen
    Citation: Fluids and Barriers of the CNS 2023 20:45
    Content type: Brief Report Published on:

  30. The treatment of hydrocephalus has been a topic of intense research ever since the first clinically successful use of a valved cerebrospinal fluid shunt 72 years ago. While ample studies elucidating different ...

    Authors: Anthony Podgoršak, Nina Eva Trimmel, Markus Florian Oertel, Sara Qvarlander, Margarete Arras, Anders Eklund, Miriam Weisskopf and Marianne Schmid Daners
    Citation: Fluids and Barriers of the CNS 2022 19:2
    Content type: Research Published on:

  32. A reduced amyloid-β (Aβ)42/40 peptide ratio in blood plasma represents a peripheral biomarker of the cerebral amyloid pathology observed in Alzheimer’s disease brains. The magnitude of the measurable effect in...

    Authors: Hans-Wolfgang Klafki, Barbara Morgado, Oliver Wirths, Olaf Jahn, Chris Bauer, Hermann Esselmann, Johannes Schuchhardt and Jens Wiltfang
    Citation: Fluids and Barriers of the CNS 2022 19:96
    Content type: Research Published on:

  33. The United States faces a national crisis involving opioid medications, where currently more than 130 people die every day. To combat this epidemic, a better understanding is needed of how opioids penetrate in...

    Authors: Jacquelyn A. Brown, Shannon L. Faley, Yajuan Shi, Kathleen M. Hillgren, Geri A. Sawada, Thomas K. Baker, John P. Wikswo and Ethan S. Lippmann
    Citation: Fluids and Barriers of the CNS 2020 17:38
    Content type: Research Published on:

  34. Post-traumatic hydrocephalus (PTH) is potentially under-diagnosed and under-treated, generating the need for a more efficient diagnostic tool. We aim to report CSF dynamics of patients with post-traumatic vent...

    Authors: Afroditi D. Lalou, Virginia Levrini, Marek Czosnyka, Laurent Gergelé, Matthew Garnett, Angelos Kolias, Peter J. Hutchinson and Zofia Czosnyka
    Citation: Fluids and Barriers of the CNS 2020 17:24
    Content type: Research Published on:

  35. Formation, maintenance, and repair of the blood–brain barrier (BBB) are critical for central nervous system homeostasis. The interaction of endothelial cells (ECs) with brain pericytes is known to induce BBB c...

    Authors: Marjolein Heymans, Ricardo Figueiredo, Lucie Dehouck, David Francisco, Yasuteru Sano, Fumitaka Shimizu, Takashi Kanda, Rémy Bruggmann, Britta Engelhardt, Peter Winter, Fabien Gosselet and Maxime Culot
    Citation: Fluids and Barriers of the CNS 2020 17:48
    Content type: Research Published on:

  36. Neurodegenerative diseases (NDs) are an accelerating global health problem. Nevertheless, the stronghold of the brain- the blood–brain barrier (BBB) prevents drug penetrance and dwindles effective treatments. ...

    Authors: Sara Hernando, Polyxeni Nikolakopoulou, Dimitrios Voulgaris, Rosa Maria Hernandez, Manoli Igartua and Anna Herland
    Citation: Fluids and Barriers of the CNS 2022 19:22
    Content type: Research Published on:

  37. The aim of this study was to describe the outcome measure timed up and go (TUG) in a large, nationwide cohort of patients with idiopathic normal pressure hydrocephalus (iNPH) pre- and post-operatively. Further...

    Authors: Nina Sundström, Johanna Rydja, Johan Virhammar, Lena Kollén, Fredrik Lundin and Mats Tullberg
    Citation: Fluids and Barriers of the CNS 2022 19:4
    Content type: Research Published on:

  38. Astrocyte endfoot processes are believed to cover all micro-vessels in the brain cortex and may play a significant role in fluid and substance transport into and out of the brain parenchyma. Detailed fluid mec...

    Authors: Timo Koch, Vegard Vinje and Kent-André Mardal
    Citation: Fluids and Barriers of the CNS 2023 20:20
    Content type: Research Published on:

    The Correction to this article has been published in Fluids and Barriers of the CNS 2023 20:57

  39. This aim of this editorial is to highlight progress made in brain barrier and brain fluid research in 2022. It covers studies on the blood-brain, blood-retina and blood-CSF barriers (choroid plexus and meninge...

    Authors: Richard F. Keep, Hazel C. Jones, Mark G. Hamilton and Lester R. Drewes
    Citation: Fluids and Barriers of the CNS 2023 20:30
    Content type: Editorial Published on:

  40. Large differences in glymphatic system transport—similar in magnitude to those of the sleep/wake cycle—have been observed during anesthesia with dexmedetomidine supplemented with low dose isoflurane (DEXM-I) i...

    Authors: Burhan O. Ozturk, Brittany Monte, Sunil Koundal, Feng Dai, Helene Benveniste and Hedok Lee
    Citation: Fluids and Barriers of the CNS 2021 18:1
    Content type: Research Published on:

  41. In the choroid plexus and pituitary gland, vasculature is known to have a permeable, fenestrated phenotype which allows for the free passage of molecules in contrast to the blood brain barrier observed in the ...

    Authors: William E. Bastedo, R. Wilder Scott, Martin Arostegui and T. Michael Underhill
    Citation: Fluids and Barriers of the CNS 2024 21:31
    Content type: Research Published on:

  42. This editorial highlights advances in brain barrier and brain fluid research in 2021. It covers research on components of the blood–brain barrier, neurovascular unit and brain fluid systems; how brain barriers...

    Authors: Richard F. Keep, Hazel C. Jones and Lester R. Drewes
    Citation: Fluids and Barriers of the CNS 2022 19:48
    Content type: Editorial Published on:

  43. Blood biomarkers of neurological diseases are often employed to rule out or confirm the presence of significant intracranial or cerebrovascular pathology or for the differential diagnosis of conditions with si...

    Authors: Robert Murcko, Nicola Marchi, Damian Bailey and Damir Janigro
    Citation: Fluids and Barriers of the CNS 2022 19:32
    Content type: Research Published on:

  44. Idiopathic Normal pressure hydrocephalus (iNPH) is a form of adult hydrocephalus that is clinically characterized by progressive gait impairment, cognitive dysfunction, and urinary incontinence. The current st...

    Authors: Sophia Weiner, Antti Junkkari, Mathias Sauer, Antti Luikku, Tuomas Rauramaa, Tarja Kokkola, Sanna-Kaisa Herukka, Kaj Blennow, Henrik Zetterberg, Ville Leinonen and Johan Gobom
    Citation: Fluids and Barriers of the CNS 2023 20:40
    Content type: Research Published on:

  45. The subcommissural organ (SCO) is a highly conserved brain gland present throughout the vertebrate phylum; it secretes glycoproteins into the cerebrospinal fluid (CSF), where they aggregate to form Reissner's ...

    Authors: Karin Vio, Sara Rodríguez, Carlos R Yulis, Cristian Oliver and Esteban M Rodríguez
    Citation: Cerebrospinal Fluid Research 2008 5:3
    Content type: Research Published on:

  46. Elevated intracranial pressure (ICP) is observed in many neurological pathologies, e.g. hydrocephalus and stroke. This condition is routinely relieved with neurosurgical approaches, since effective and targete...

    Authors: Dagne Barbuskaite, Eva K. Oernbo, Jonathan H. Wardman, Trine L. Toft-Bertelsen, Eller Conti, Søren N. Andreassen, Niklas J. Gerkau, Christine R. Rose and Nanna MacAulay
    Citation: Fluids and Barriers of the CNS 2022 19:53
    Content type: Research Published on:

  47. Oligoclonal IgG bands in cerebrospinal fluid that are absent in serum indicate intrathecal IgG synthesis and are a sensitive marker of CNS inflammatory diseases, in particular multiple sclerosis. It may be of ...

    Authors: David Zeman, Pavel Hradílek, Zdeněk Švagera, Eva Mojžíšková, Ivana Woznicová and Olga Zapletalová
    Citation: Fluids and Barriers of the CNS 2012 9:5
    Content type: Study protocol Published on:

  48. Although widely used in the evaluation of the diseased, normal intracranial pressure and lumbar cerebrospinal fluid pressure remain sparsely documented. Intracranial pressure is different from lumbar cerebrosp...

    Authors: Nicolas Hernandez Norager, Markus Harboe Olsen, Sarah Hornshoej Pedersen, Casper Schwartz Riedel, Marek Czosnyka and Marianne Juhler
    Citation: Fluids and Barriers of the CNS 2021 18:19
    Content type: Research Published on:

  49. The composition of tissue obstructing neuroprosthetic devices is largely composed of inflammatory cells with a significant astrocyte component. In a first-of-its-kind study, we profile the astrocyte phenotypes...

    Authors: Fatemeh Khodadadei, Rooshan Arshad, Diego M. Morales, Jacob Gluski, Neena I. Marupudi, James P. McAllister II, David D. Limbrick Jr. and Carolyn A. Harris
    Citation: Fluids and Barriers of the CNS 2022 19:78
    Content type: Research Published on:

  50. Glucose transport from the blood into the brain is tightly regulated by brain microvascular endothelial cells (BMEC), which also use glucose as their primary energy source. To study how BMEC glucose transport ...

    Authors: Callie M. Weber, Bilal Moiz, Sophia M. Zic, Viviana Alpízar Vargas, Andrew Li and Alisa Morss Clyne
    Citation: Fluids and Barriers of the CNS 2022 19:98
    Content type: Research Published on:
Submit manuscript
  • ISSN: 2045-8118 (electronic)

Fluids and Barriers of the CNS

ISSN: 2045-8118