The definition and classification of hydrocephalus: a personal recommendation to stimulate debate
© Rekate; licensee BioMed Central Ltd. 2008
Received: 15 October 2007
Accepted: 22 January 2008
Published: 22 January 2008
The aim of this review is to refine the definition and classification of hydrocephalus as a preview to developing an international consensus on the nomenclature of this complex condition. This proposed definition and classification is based on my own work in this area and is intended to promote a debate on the concepts presented.
A literature review of contemporary definitions and classifications of hydrocephalus, and of the historic context in which these concepts developed, is presented. Based on new technology and understanding of hydrocephalus, the rationale for nomenclature is also discussed.
Currently, there is no recognized definition of hydrocephalus. The failure to agree on a working definition impedes progress in understanding the pathophysiology and treatment of hydrocephalus. There are many proposed classifications, each with its own starting point in terms of the definition of the condition. This author recommends that the following definition be used as a starting point to develop a consensus statement defining hydrocephalus: "Hydrocephalus is an active distension of the ventricular system of the brain resulting from inadequate passage of cerebrospinal fluid from its point of production within the cerebral ventricles to its point of absorption into the systemic circulation." Such a definition can be used to develop a rational classification consistent with observations from contemporary neuroimaging and can lead to testable hypotheses. It is concluded that hydrocephalus is a complicated neurologic disorder with many causes and methods of treatment. Clinicians and basic scientists must agree on a working definition of the condition to be able to interpret results from different investigators. Reaching a consensus on a working definition and functional classification should be a high priority for researchers in this field.
An electronic search of the medical literature using a National Library of Medicine database (PubMed) using the words "hydrocephalus" and "definition" yielded 77 titles. Only five of these articles actually attempted to define hydrocephalus. The concepts on which these definitions were based were disparate and these potential definitions shared few commonalities [1–8].
In an attempt to be as inclusive as possible, Raimondi  defined cerebrospinal fluid (CSF) as all fluid within the intracranial compartment except blood. With that starting point, hydrocephalus was defined as any increase in CSF within the intracranial compartment, including edema and hydrocephalus ex vacuo. This straightforward definition allowed many pathologies not universally recognized as hydrocephalus by researchers, such as vasogenic and cytotoxic edema, to be incorporated into CSF pathophysiology. This attempted definition did not gain widespread acceptance, partially due to its failure to lead to changes in understanding or treatment of the conditions that were included in the definition.
In an extensive study supported by the Ministry of Health and Welfare of Japan, Mori and colleagues reviewed a database of 1450 patients with hydrocephalus to develop a classification that would allow outcome to be predicted in individual cases. They excluded tumoral hydrocephalus and defined eight subtypes of hydrocephalus in relationship to the time of onset and severity of brain malformation or injury. They proposed that one of the diagnoses should be "intractable hydrocephalus." They submitted criteria for this tragic condition for which treatment is futile. The general results of the study were that hydrocephalus is not a disease but a symptom or sign that relates to CSF dynamics [3, 4].
Classifications of hydrocephalus
All intracranial fluids except blood found in excess
Includes vasogenic and cytotoxic edema
Includes brain atrophy and hydrocephalus ex vacuo
Definition of intractable hydrocephalus
In which case is intervention futile?
Includes all abnormalities of CSF pressure and volume
Includes arrested hydrocephalus and cysts
Obstructive vs communicating forms limited to infants and small children
Classification devised to define babies who may be candidates for third ventriculostomy
Classification of infantile and fetal hydrocephalus based on CNS developmental state
Prognosis is dependent on what is occurring at the time the pathology develops. May be a rationale for in utero surgery
Based on point of obstruction and developed on a mathematical model
Assumes all hydrocephalus is obstructive
From the above discussion, it is clear that despite numerous "consensus conferences" on the subject of hydrocephalus, there is no consensus on the definition of this problem. The goal of this article is to propose a "straw man" definition to serve as a starting point for a discussion for future meetings so that clinicians and basic scientists can develop a common language. The ultimate goal would be to motivate investigators to work collaboratively toward improvements in treatment paradigms for hydrocephalus.
A modest definition
As a starting point for future discussions, I propose the following definition of hydrocephalus: "Hydrocephalus is an active distension of the ventricular system of the brain resulting from inadequate passage of CSF from its point of production within the cerebral ventricles to its point of absorption into the systemic circulation." The elements of this definition are simple and therefore, the number of processes included within it is limited and manageable. Hydrocephalus is an active condition. It is a process that can be demonstrated on neuroimaging studies, and the definition suggests that there is a common underlying cause for its different manifestations: a mismatch between CSF production and its absorption.
Because the definition requires an active process, it excludes brain atrophy or ex vacuo hydrocephalus. Similarly, because this definition requires ventricular distention (ventriculomegaly), it excludes conditions in which there is a failure of CSF absorption such as pseudotumor cerebri (also called benign intracranial hypertension) and normal volume hydrocephalus, this latter being limited to patients shunted during infancy, but found to have increased intracranial pressure (ICP) without ventricular distension at the time of shunt failure . The exclusion of these two conditions will provoke especially energetic debate. It is clear that they are close relatives of hydrocephalus as they are associated with high intracranial pressure and are caused by an increase in the resistance to flow of CSF. They are excluded from the above definition because of the absence of ventricular dilatation. This is a point for general discussion.
The definition does not require an increased ICP even though that condition usually co-exists. Therefore, the conditions of idiopathic and secondary normal pressure hydrocephalus (NPH) are included. Acceptance of this definition, or one that incorporates these concepts, offers researchers and clinicians a common language and the opportunity to develop a useful classification system, which should be the goal of a future consensus conference.
The proposed definition requires no specific pathologic process. It does not require a researcher to abandon commitment to a bulk flow concept of CSF dynamics or a concept of pulsatility. It also does not require a commitment to an ability to define how CSF is produced, how it is absorbed, or where it is absorbed. It is a point of departure that allows studies on basic aspects of pathophysiology to be incorporated into the definition.
Classification of hydrocephalus: historical aspects
Research into the pathophysiology and treatment of hydrocephalus began with the work of Dandy and Blackfan in the early decades of the twentieth century . At that time little was known about the pathophysiology much less about the treatment of hydrocephalus. Plain radiography and lumbar puncture were the only studies that could be performed on hydrocephalic patients or experimental animals. Late in his career, Dandy was influential in the development of pneumoventriculography, which first allowed neuroanatomic features to be defined in living patients and animal models.
Initially, these investigators were limited to studying hydrocephalus using ventricular puncture and lumbar puncture. With these tools, Dandy and his pediatrician colleague, Blackfan, performed ventricular punctures and injected supravital dyes into ventricles and later performed lumbar punctures. If the dye was recovered in the spinal tap, the hydrocephalus was classified as "communicating." If no dye was recovered in the lumbar theca, the hydrocephalus was considered "obstructive" or "non-communicating." Dandy also performed experiments that defined the choroid plexus as the source of the production of CSF [10, 11].
Based on these experiments and on clinical observations, Dandy and later investigators developed techniques designed to treat or at least to ameliorate hydrocephalus, which at that time was essentially a death sentence. Dandy and others attempted to perform internal bypasses called third ventriculostomies via an open craniotomy or endoscopically via a cystoscope or choroid plexectomy. In general, all of these techniques were unsuccessful due to the severity of the hydrocephalus diagnosed in those times.
This classification of communicating or obstructive (non-communicating) was extremely useful for understanding hydrocephalus as well as for guiding the search for therapeutic options for the management of the condition. Soon, however, the classification was recognized as an inadequate portrayal of the pathophysiology underlying hydrocephalus. In a brilliant but infrequently cited study, Ransohoff and colleagues reviewed and updated Dandy's ideas . These researchers realized that the crude techniques available to Dandy were inadequate to understand the spectrum of diseases that led to hydrocephalus. They updated the classification to incorporate what was then understood of the pathophysiology of the condition and proposed that Dandy's classification be modified.
Ransohoff et al postulated that there were a variety of potential sites of obstruction to the flow of CSF and thought that all hydrocephalus was obstructive . Using the same criteria that Dandy had used, Ransohoff's group agreed that patients had obstructive hydrocephalus when dye in the ventricles did not communicate with the lumbar theca. However, they believed that the point of obstruction was at the aqueduct of Sylvius or at the outlet foramina of the fourth ventricle. They suggested that this form of hydrocephalus be called "intraventricular obstructive" hydrocephalus. They still believed that hydrocephalus associated with CSF flow from the ventricular system to the lumbar theca was an obstructive process involving scarring of the cortical subarachnoid spaces or failure of the terminal absorption of CSF, presumably, by the arachnoid villi. They proposed that this condition should be called "extraventricular obstructive" hydrocephalus .
This nomenclature was useful for a variety of reasons. At that time the only available form of treatment for intraventricular obstructive hydrocephalus involved shunting from the ventricle to the atrium of the heart, ureter, or occasionally to the peritoneum. If the lumbar theca was found to be in communication with the ventricular system, the somewhat safer option of shunting the lumbar theca was possible. At this point, effective surgical treatments became available for the control of hydrocephalus, and the Ransohoff classification was useful in selecting from the several treatment paradigms.
In 1973 the first computerized tomography (CT) scanner was installed in the United States. For the first time, noninvasive techniques were available to define the point of obstruction in hydrocephalus. In the early 1980s magnetic resonance imaging (MRI) became available and provided improved resolution to define the actual point of obstruction of CSF flow that led to hydrocephalus. Hydrocephalus progressed from two types, as defined by the techniques available to Dandy, to multiple finite types that could be defined and treated by specific techniques.
The CSF pathway as a circuit diagram
There are two potential explanations for the failure to measure pressure differentials elsewhere in the system. Firstly, most transducers available for these studies are only accurate to ± 1 mm Hg. Given that the bulk flow of CSF is 0.33 ml/min, we could have failed to detect these pressure differentials if they were lower than the threshold of our instrumentation. To overcome this problem, we infused artificial CSF into the various components. However, we were still unable to measure pressure differentials. The second possibility, which we prefer as an explanation, relates to the viscoelastic properties of the brain itself. The brain has the potential to change its shape and orientation. As soon as a pressure gradient is produced, the brain likely shifts from a point of higher pressure to one of lower pressure. This scenario would explain our inability to measure ventricular-subarachnoid pressure gradients even when CSF flow was obstructed completely.
Each point of potential obstruction (Fig. 1) represents a specific subtype or class of hydrocephalus. This model offers a possible substrate for a useful classification of hydrocephalus based on the point of obstruction, which is possible to define based on contemporary neuroimaging [14, 17].
Contemporary classification based on neuroimaging
With the rare exception of hydrocephalus associated with overproduction of CSF in patients with choroid plexus papillomas (CPPs), all hydrocephalus is basically obstructive. That the rare CPP causes hydrocephalus is not debated, but why it does so is the subject of some discussion. CPPs are known to lead to increases in the rate of CSF production and are known to cause hydrocephalus.
Normal CSF absorptive mechanisms can clear the amount of spinal fluid produced in the ventricular system at extremely high rates without producing ventriculomegaly. If CSF production and ICP increase substantially, ventricular size increases . When CSF flow is obstructed in the context of increased CSF production, there is a great tendency for ventriculomegaly or hydrocephalus to develop. CPPs, in themselves, can create the only pure form of "communicating" hydrocephalus. However, that these tumors tend to be large and to restrict CSF flow through the foramen of Monro or aqueduct of Sylvius, is more likely to account for the severity of hydrocephalus in this context .
Proposed classification based on defined points of obstruction
When hydrocephalus is severe, especially in the very young, it may not be possible to define the point of CSF obstruction without introducing tracers into the CSF pathways. In patients treated early in life whose ventricles have become smaller with treatment, it is possible to determine the first site of obstruction to CSF flow on MRI or CT.
Proposed classification of hydrocephalus
Site of Obstruction
Choroid plexus papilloma
Foramen of Monro
Tumor, congenital anomaly, postshunt ventricular asymmetry
Tumor removal, septum pellucidotomy, ventricle shunt
Aqueduct of Sylvius
Congenital lesion, tumor secondary to extraventricular obstruction
ETV, ventricular shunting
Outlets of fourth ventricle
Chronic meningitis, Chiari II malformation
ETV, ventricular shunting
Meningitis, post subarachnoid hemorrhage
ETV, ventricle shunt, spinal thecal shunt
Hemorrhage or infection in infancy
Ventricle or thecal shunt
Skull base anomalies, congenital heart disease
Ventricle or thecal shunt, treatment of vascular anomaly if possible
The above discussion is one way of analyzing hydrocephalus and its classification. It meets the requirements for effective classification as set forth above, improves understanding of the condition, and points to areas that can be improved by ongoing research efforts. Nonetheless, other potential classifications, including those based on age, underlying cause of hydrocephalus, or neurologic outcomes, need to be analyzed. There has been considerable interest in the possibility that hydrocephalus may develop as a result of pulsatility causing ventricular dilatation [21, 22]. This aspect of hydrocephalus and the intrinsic viscoelastic properties of the brain relate to the different responses among patients with the same anatomic lesions and degree of obstruction . In the future, this aspect of hydrocephalus may need to be included in a comprehensive classification scheme.
Obtaining a consensus on a working definition of hydrocephalus and especially on a method of classifying this complicated condition is a challenge worth pursuing. A consensus would improve the focus on basic research, the development of logical approaches to treatment decisions, the planning of prospective trials, and the development of new technologies to improve the outcomes of this most chronic of medical conditions.
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