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  1. Authors: Ignacio Jusue-Torres, Jennifer Lu, Eric W Sankey, Tito Vivas-Buitrago, Joshua Crawford, Mikhail Pletnikov, Jiadi Xu, Ari Blitz, Barbara Crain, Alicia Hulbert, Hugo Guerrero-Cazares, Oscar Gonzalez-Perez, Alfredo Quiñones-Hinojosa, Pat McAllister and Daniele Rigamonti

    Citation: Fluids and Barriers of the CNS 2015 12(Suppl 1):O57

    Content type: Oral presentation

    Published on:

    This article is part of a Supplement: Volume 12 Supplement 1

  2. Authors: Joel Huovinen, Sami Kastinen, Simo Komulainen, Minna Oinas, Cecilia Avellan, Janek Franzen, Jaakko Rinne, Antti Ronkainen, Mikko Kauppinen, Kimmo Lönroth, Markus Perola, Okko T Pyykkö, Anne M Koivisto, Anne M Remes, Mikko Hiltunen, Seppo Helisalmi…

    Citation: Fluids and Barriers of the CNS 2015 12(Suppl 1):O43

    Content type: Oral presentation

    Published on:

    This article is part of a Supplement: Volume 12 Supplement 1

  3. Authors: Edward W Dyson, Aswin Chari, Andrew R Stevens, Simon D Thompson, Claudia Craven, Patricia Haylock-Vize, Samir A Matloob, Syed N Shah, Huan Wee Chan, Neekhil A Patel, Tarek Mostafa, Jinendra Ekanayake, Ahmed K Toma, Lewis W Thorne and Laurence D Watkins

    Citation: Fluids and Barriers of the CNS 2015 12(Suppl 1):O29

    Content type: Oral presentation

    Published on:

    This article is part of a Supplement: Volume 12 Supplement 1

  4. Authors: Aswin Chari, Edward W Dyson, Andrew R Stevens, Simon D Thompson, Claudia Craven, Samir A Matloob, Huan Wee Chan, Syed N Shah, Tarek Mostafa, Neekhil A Patel, Jinendra Ekanayake, Patricia Haylock-Vize, Ahmed K Toma and Laurence D Watkins

    Citation: Fluids and Barriers of the CNS 2015 12(Suppl 1):O14

    Content type: Oral presentation

    Published on:

    This article is part of a Supplement: Volume 12 Supplement 1

  5. Authors: Ignacio Jusue-Torres, Jennifer Lu, Eric W Sankey, Tito Vivas-Buitrago, Joshua Crawford, Mikhail Pletnikov, Jiadi Xu, Ari Blitz, Barbara Crain, Alicia Hulbert, Hugo Guerrero-Cazares, Oscar Gonzalez-Perez, Alfredo Quiñones-Hinojosa, Pat McAllister and Daniele Rigamonti

    Citation: Fluids and Barriers of the CNS 2015 12(Suppl 1):O13

    Content type: Oral presentation

    Published on:

    This article is part of a Supplement: Volume 12 Supplement 1

  6. We recently reported that bacterial lipopolysaccharide (LPS)-induced inflammation decreases the expression of the primary thyroid hormone transporters at the blood–brain barrier, organic anion-transporting pol...

    Authors: Gábor Wittmann, Petra Mohácsik, Mumtaz Yaseen Balkhi, Balázs Gereben and Ronald M. Lechan

    Citation: Fluids and Barriers of the CNS 2015 12:21

    Content type: Research

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  7. The aim of this review is to outline evidence that adenosine receptor (AR) activation can modulate blood–brain barrier (BBB) permeability and the implications for disease states and drug delivery. Barriers of ...

    Authors: Margaret S. Bynoe, Christophe Viret, Angela Yan and Do-Geun Kim

    Citation: Fluids and Barriers of the CNS 2015 12:20

    Content type: Review

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  8. Primary brain capillary endothelial cells (BCECs) are a promising tool to study the blood–brain barrier (BBB) in vitro, as they maintain many important characteristics of the BBB in vivo, especially when co-cu...

    Authors: Annette Burkhart, Louiza Bohn Thomsen, Maj Schneider Thomsen, Jacek Lichota, Csilla Fazakas, István Krizbai and Torben Moos

    Citation: Fluids and Barriers of the CNS 2015 12:19

    Content type: Research

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  9. Diabetes and tobacco smoking are significant public health concerns which have been shown to independently impact the blood–brain barrier (BBB). Since smoking is a risk factor for diabetes and shares some of t...

    Authors: Shikha Prasad, Ravi K Sajja, Jee Hyun Park, Pooja Naik, Mohammad Abul Kaisar and Luca Cucullo

    Citation: Fluids and Barriers of the CNS 2015 12:18

    Content type: Research

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  10. The apolipoprotein B-100 (ApoB-100) transgenic mouse line is a model of human atherosclerosis. Latest findings suggest the importance of ApoB-100 in the development of neurodegenerative diseases and microvascu...

    Authors: Nikolett Lénárt, Fruzsina R Walter, Alexandra Bocsik, Petra Sántha, Melinda E Tóth, András Harazin, Andrea E Tóth, Csaba Vizler, Zsolt Török, Ana-Maria Pilbat, László Vígh, László G Puskás, Miklós Sántha and Mária A Deli

    Citation: Fluids and Barriers of the CNS 2015 12:17

    Content type: Research

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  11. In a recent review article titled “A new look at cerebrospinal fluid circulation”, Brinker et al. comprehensively described novel insights from molecular and cellular biology as well as neuroimaging research, ...

    Authors: Peter Wostyn, Debby Van Dam, Kurt Audenaert, Hanspeter Esriel Killer, Peter Paul De Deyn and Veva De Groot

    Citation: Fluids and Barriers of the CNS 2015 12:16

    Content type: Commentary

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  12. Virchow–Robin spaces (VRS) are brain perivascular spaces containing perforating arteries. Although enlarged VRS are associated with various disorders such as Alzheimer’s disease, cerebrovascular disease, and h...

    Authors: Masatsune Ishikawa, Shigeki Yamada and Kazuo Yamamoto

    Citation: Fluids and Barriers of the CNS 2015 12:15

    Content type: Research

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  13. Time-spatial labeling inversion pulse (Time-SLIP) magnetic resonance imaging allows non-invasive visualization of cerebrospinal fluid (CSF) movement. Our study evaluated the sensitivity of the Time-SLIP tag pl...

    Authors: Erik H Middlebrooks, Jeffrey A Bennett and Alissa Old Crow

    Citation: Fluids and Barriers of the CNS 2015 12:14

    Content type: Short paper

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  14. Brain microvascular-like endothelial cells (BMECs) derived from human pluripotent stem cells (hPSCs) have significant promise as tools for drug screening and studying the structure and function of the BBB in h...

    Authors: Hannah K Wilson, Scott G Canfield, Michael K Hjortness, Sean P Palecek and Eric V Shusta

    Citation: Fluids and Barriers of the CNS 2015 12:13

    Content type: Research

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  15. The chemokine CXCL13 has been discussed as a diagnostic parameter with high specificity for Lyme neuroborreliosis (LNB) and as a marker of disease activity. Neurosyphilis and LNB share similar characteristics....

    Authors: R Dersch, T Hottenrott, M Senel, V Lehmensiek, H Tumani, S Rauer and O Stich

    Citation: Fluids and Barriers of the CNS 2015 12:12

    Content type: Short paper

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  16. L-Glutamate (L-Glu) is the major excitatory neurotransmitter in the CNS, and its level in cerebrospinal fluid (CSF) is reported to be increased in neuroexcitatory diseases such as epilepsy. Since L-Glu concent...

    Authors: Shin-ichi Akanuma, Tatsuhiko Sakurai, Masanori Tachikawa, Yoshiyuki Kubo and Ken-ichi Hosoya

    Citation: Fluids and Barriers of the CNS 2015 12:11

    Content type: Research

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  17. With growing electronic cigarette usage in both the smoking and nonsmoking population, rigorous studies are needed to investigate the effects of nicotine on biological systems to determine long-term health con...

    Authors: Kaushik K Shah, Purushotham Reddy Boreddy and Thomas J Abbruscato

    Citation: Fluids and Barriers of the CNS 2015 12:10

    Content type: Research

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  18. The objective was to identify changes in quantitative MRI measures in patients with idiopathic normal pressure hydrocephalus (iNPH) occurring in common after oral acetazolamide (ACZ) and external lumbar draina...

    Authors: Milos Ivkovic, Martin Reiss-Zimmermann, Heather Katzen, Matthias Preuss, Ilhami Kovanlikaya, Linda Heier, Noam Alperin, Karl T Hoffmann and Norman Relkin

    Citation: Fluids and Barriers of the CNS 2015 12:9

    Content type: Research

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  19. The cerebrospinal fluid (CSF) circulatory system is involved in neuroimmune regulation, cerebral detoxification, and delivery of various endogenous and exogenous substances. In conjunction with the choroid ple...

    Authors: Jean-François Ghersi-Egea, Anaïd Babikian, Sandrine Blondel and Nathalie Strazielle

    Citation: Fluids and Barriers of the CNS 2015 12:8

    Content type: Research

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  20. Because in vitro blood–brain barrier (BBB) models are important tools for studying brain diseases and drug development, we recently established a new line of conditionally immortalized human brain microvascular e...

    Authors: Tomomi Furihata, Shinya Kawamatsu, Ryo Ito, Kosuke Saito, Shota Suzuki, Satoshi Kishida, Yoshiro Saito, Atsuko Kamiichi and Kan Chiba

    Citation: Fluids and Barriers of the CNS 2015 12:7

    Content type: Research

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  21. Activation of microglia/macrophages following cerebral ischemia may be beneficial or detrimental for the survival of brain cells, an ambiguity in effects that has been explained by findings that ischemia can i...

    Authors: Rawan Barakat and Zoran Redzic

    Citation: Fluids and Barriers of the CNS 2015 12:6

    Content type: Research

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  22. Blockade of vascular endothelial growth factor (VEGF) to promote vascular normalization and inhibit angiogenesis has been proposed for the treatment of brain metastases; however, vascular normalization has not...

    Authors: Gregory L Pishko, Leslie L Muldoon, Michael A Pagel, Daniel L Schwartz and Edward A Neuwelt

    Citation: Fluids and Barriers of the CNS 2015 12:5

    Content type: Research

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  23. Undisturbed functioning of the blood–brain barrier (BBB) crucially depends on paracellular signaling between its associated cells; particularly endothelial cells, pericytes and astrocytes. Hypoxic and ischemic...

    Authors: Sabrina Engelhardt, Sheng-Fu Huang, Shalmali Patkar, Max Gassmann and Omolara O Ogunshola

    Citation: Fluids and Barriers of the CNS 2015 12:4

    Content type: Research

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  24. Beta-endorphin (β-END) is an opioid neuropeptide which has an important role in the development of hypotheses concerning the non-synaptic or paracrine communication of brain messages. This kind of communicatio...

    Authors: Jan G Veening and Henk P Barendregt

    Citation: Fluids and Barriers of the CNS 2015 12:3

    Content type: Review

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  25. Normal pressure hydrocephalus (NPH) is most common in the elderly and has a high co-morbidity with Alzheimer’s disease (AD) and cerebrovascular disease (CVD). To understand the relationship between NPH, AD and...

    Authors: Gerald D Silverberg, Miles C Miller, Crissey L Pascale, Ilias N Caralopoulos, Yuksel Agca, Cansu Agca and Edward G Stopa

    Citation: Fluids and Barriers of the CNS 2015 12:2

    Content type: Research

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  26. In June 2014 Dr. Joseph D. Fenstermacher celebrated his 80th birthday, which was honored by the symposium held in New London, NH, USA. This review discusses Fenstermacher’s contribution to the field of fluids ...

    Authors: Adam Chodobski, Jean-François Ghersi-Egea, Charles Nicholson, Tavarekere N Nagaraja and Joanna Szmydynger-Chodobska

    Citation: Fluids and Barriers of the CNS 2015 12:1

    Content type: Review

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  27. We have recently shown that mice with experimental autoimmune encephalomyelitis (EAE) have increased sleep fragmentation (SF) and reduced sleep efficiency, and that the extent of SF correlates with the severit...

    Authors: Junyun He, Hung Hsuchou, Yi He, Abba J Kastin, Pramod K Mishra, Jidong Fang and Weihong Pan

    Citation: Fluids and Barriers of the CNS 2014 11:27

    Content type: Research

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  28. Cefadroxil, a cephalosporin antibiotic, is a substrate for several membrane transporters including peptide transporter 2 (PEPT2), organic anion transporters (OATs), multidrug resistance-associated proteins (MR...

    Authors: Xiaomei Chen, Irena Loryan, Maryam Payan, Richard F Keep, David E Smith and Margareta Hammarlund-Udenaes

    Citation: Fluids and Barriers of the CNS 2014 11:25

    Content type: Research

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  29. Incidental white matter hyperintensities (WMHs) are common findings on T2-weighted magnetic resonance images of the aged brain and have been associated with cognitive decline. While a variety of pathogenic mechan...

    Authors: Valerie C Anderson, James T Obayashi, Jeffrey A Kaye, Joseph F Quinn, Phillip Berryhill, Louis P Riccelli, Dean Peterson and William D Rooney

    Citation: Fluids and Barriers of the CNS 2014 11:24

    Content type: Research

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  30. A tool for standardized and repeated neuropsychological assessments in patients with idiopathic normal pressure hydrocephalus (INPH) is needed. The objective of this study was to develop a computerized neurops...

    Authors: Anders Behrens, Anders Eklund, Eva Elgh, Cynthia Smith, Michael A Williams and Jan Malm

    Citation: Fluids and Barriers of the CNS 2014 11:22

    Content type: Research

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  31. Limiting expansion of the ischemic core lesion by reinstating blood flow and protecting the penumbral cells is a priority in acute stroke treatment. However, at present, methods are not available for effective...

    Authors: Tavarekere N Nagaraja, Kelly A Keenan, Madhava P Aryal, James R Ewing, Saarang Gopinath, Varun S Nadig, Sukruth Shashikumar and Robert A Knight

    Citation: Fluids and Barriers of the CNS 2014 11:21

    Content type: Research

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  32. Idiopathic normal pressure hydrocephalus (iNPH) is one of few types of dementia that can be treated with shunt surgery and cerebrospinal fluid (CSF) diversion. It is frequently present with cerebral vasculopat...

    Authors: Per Kristian Eide and Are Hugo Pripp

    Citation: Fluids and Barriers of the CNS 2014 11:19

    Content type: Short paper

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  33. This article reviews current knowledge of the mechanisms underlying the initial hemorrhage and secondary blood–brain barrier (BBB) dysfunction in primary spontaneous intracerebral hemorrhage (ICH) in adults. M...

    Authors: Richard F Keep, Ningna Zhou, Jianming Xiang, Anuska V Andjelkovic, Ya Hua and Guohua Xi

    Citation: Fluids and Barriers of the CNS 2014 11:18

    Content type: Review

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  34. Brinker et al. extensively reviewed recent findings about CSF circulation in a recent article: “A new look at cerebrospinal circulation”, but did not analyze some important available data in sufficient detail. Fo...

    Authors: Darko Orešković and Marijan Klarica

    Citation: Fluids and Barriers of the CNS 2014 11:16

    Content type: Commentary

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  35. Glutaric acid (GA) is a dicarboxylic acid that accumulates in millimolar concentrations in glutaric acidemia I (GA-I), an inherited neurometabolic childhood disease characterized by extensive neurodegeneration...

    Authors: Eugenia Isasi, Luis Barbeito and Silvia Olivera-Bravo

    Citation: Fluids and Barriers of the CNS 2014 11:15

    Content type: Research

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  36. Highly abundant proteins in biological fluids such as serum or cerebrospinal fluid (CSF) can hinder the detection of proteins in lower abundance, e.g., potential biomarkers. Commercial products are available for ...

    Authors: Ramona Günther, Eberhard Krause, Michael Schümann, Jérome Ausseil, Jean-Michel Heard, Ingolf E Blasig and Reiner F Haseloff

    Citation: Fluids and Barriers of the CNS 2014 11:14

    Content type: Short paper

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  37. This editorial announces a new affiliation between Fluids and Barriers of the CNS (FBCNS) and the International Brain Barriers Society (IBBS) with mutual benefits to the journal and to society members. This is a ...

    Authors: Lester R Drewes, Hazel C Jones and Richard F Keep

    Citation: Fluids and Barriers of the CNS 2014 11:13

    Content type: Editorial

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  38. Many aspects of CSF dynamics are poorly understood due to the difficulties involved in quantification and visualization. In particular, there is debate surrounding the route of CSF drainage. Our aim was to qua...

    Authors: Lucy A Murtha, Qing Yang, Mark W Parsons, Christopher R Levi, Daniel J Beard, Neil J Spratt and Damian D McLeod

    Citation: Fluids and Barriers of the CNS 2014 11:12

    Content type: Research

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  39. The lack of absorption of CSF at the vertex in chronic hydrocephalus has been ascribed to an elevation in the arachnoid granulation outflow resistance (Rout). The CSF infusion studies measuring Rout are dependent...

    Authors: Grant A Bateman and Sabbir H Siddique

    Citation: Fluids and Barriers of the CNS 2014 11:11

    Content type: Research

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  40. According to the traditional understanding of cerebrospinal fluid (CSF) physiology, the majority of CSF is produced by the choroid plexus, circulates through the ventricles, the cisterns, and the subarachnoid ...

    Authors: Thomas Brinker, Edward Stopa, John Morrison and Petra Klinge

    Citation: Fluids and Barriers of the CNS 2014 11:10

    Content type: Review

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  41. Idiopathic normal pressure hydrocephalus (iNPH) is a treatable cause of dementia, gait disturbance, and urinary incontinence in elderly patients with ventriculomegaly. Its unique morphological feature, called ...

    Authors: Namiko Nishida, Nanae Nagata, Hiroki Toda, Naoto Jingami, Kengo Uemura, Akihiko Ozaki, Mitsuhito Mase, Yoshihiro Urade, Sadayuki Matsumoto, Koichi Iwasaki and Masatsune Ishikawa

    Citation: Fluids and Barriers of the CNS 2014 11:9

    Content type: Research

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  42. Cerebrovascular complications involving endothelial dysfunction at the blood-brain barrier (BBB) are central to the pathogenesis of diabetes-related CNS disorders. However, clinical and experimental studies ha...

    Authors: Ravi K Sajja, Shikha Prasad and Luca Cucullo

    Citation: Fluids and Barriers of the CNS 2014 11:8

    Content type: Research

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