Skip to main content

Advertisement

Articles

Page 7 of 19

  1. The chemokine CXCL13 has been discussed as a diagnostic parameter with high specificity for Lyme neuroborreliosis (LNB) and as a marker of disease activity. Neurosyphilis and LNB share similar characteristics....

    Authors: R Dersch, T Hottenrott, M Senel, V Lehmensiek, H Tumani, S Rauer and O Stich

    Citation: Fluids and Barriers of the CNS 2015 12:12

    Content type: Short paper

    Published on:

  2. L-Glutamate (L-Glu) is the major excitatory neurotransmitter in the CNS, and its level in cerebrospinal fluid (CSF) is reported to be increased in neuroexcitatory diseases such as epilepsy. Since L-Glu concent...

    Authors: Shin-ichi Akanuma, Tatsuhiko Sakurai, Masanori Tachikawa, Yoshiyuki Kubo and Ken-ichi Hosoya

    Citation: Fluids and Barriers of the CNS 2015 12:11

    Content type: Research

    Published on:

  3. With growing electronic cigarette usage in both the smoking and nonsmoking population, rigorous studies are needed to investigate the effects of nicotine on biological systems to determine long-term health con...

    Authors: Kaushik K Shah, Purushotham Reddy Boreddy and Thomas J Abbruscato

    Citation: Fluids and Barriers of the CNS 2015 12:10

    Content type: Research

    Published on:

  4. The objective was to identify changes in quantitative MRI measures in patients with idiopathic normal pressure hydrocephalus (iNPH) occurring in common after oral acetazolamide (ACZ) and external lumbar draina...

    Authors: Milos Ivkovic, Martin Reiss-Zimmermann, Heather Katzen, Matthias Preuss, Ilhami Kovanlikaya, Linda Heier, Noam Alperin, Karl T Hoffmann and Norman Relkin

    Citation: Fluids and Barriers of the CNS 2015 12:9

    Content type: Research

    Published on:

  5. The cerebrospinal fluid (CSF) circulatory system is involved in neuroimmune regulation, cerebral detoxification, and delivery of various endogenous and exogenous substances. In conjunction with the choroid ple...

    Authors: Jean-François Ghersi-Egea, Anaïd Babikian, Sandrine Blondel and Nathalie Strazielle

    Citation: Fluids and Barriers of the CNS 2015 12:8

    Content type: Research

    Published on:

  6. Because in vitro blood–brain barrier (BBB) models are important tools for studying brain diseases and drug development, we recently established a new line of conditionally immortalized human brain microvascular e...

    Authors: Tomomi Furihata, Shinya Kawamatsu, Ryo Ito, Kosuke Saito, Shota Suzuki, Satoshi Kishida, Yoshiro Saito, Atsuko Kamiichi and Kan Chiba

    Citation: Fluids and Barriers of the CNS 2015 12:7

    Content type: Research

    Published on:

  7. Activation of microglia/macrophages following cerebral ischemia may be beneficial or detrimental for the survival of brain cells, an ambiguity in effects that has been explained by findings that ischemia can i...

    Authors: Rawan Barakat and Zoran Redzic

    Citation: Fluids and Barriers of the CNS 2015 12:6

    Content type: Research

    Published on:

  8. Blockade of vascular endothelial growth factor (VEGF) to promote vascular normalization and inhibit angiogenesis has been proposed for the treatment of brain metastases; however, vascular normalization has not...

    Authors: Gregory L Pishko, Leslie L Muldoon, Michael A Pagel, Daniel L Schwartz and Edward A Neuwelt

    Citation: Fluids and Barriers of the CNS 2015 12:5

    Content type: Research

    Published on:

  9. Undisturbed functioning of the blood–brain barrier (BBB) crucially depends on paracellular signaling between its associated cells; particularly endothelial cells, pericytes and astrocytes. Hypoxic and ischemic...

    Authors: Sabrina Engelhardt, Sheng-Fu Huang, Shalmali Patkar, Max Gassmann and Omolara O Ogunshola

    Citation: Fluids and Barriers of the CNS 2015 12:4

    Content type: Research

    Published on:

  10. Beta-endorphin (β-END) is an opioid neuropeptide which has an important role in the development of hypotheses concerning the non-synaptic or paracrine communication of brain messages. This kind of communicatio...

    Authors: Jan G Veening and Henk P Barendregt

    Citation: Fluids and Barriers of the CNS 2015 12:3

    Content type: Review

    Published on:

  11. Normal pressure hydrocephalus (NPH) is most common in the elderly and has a high co-morbidity with Alzheimer’s disease (AD) and cerebrovascular disease (CVD). To understand the relationship between NPH, AD and...

    Authors: Gerald D Silverberg, Miles C Miller, Crissey L Pascale, Ilias N Caralopoulos, Yuksel Agca, Cansu Agca and Edward G Stopa

    Citation: Fluids and Barriers of the CNS 2015 12:2

    Content type: Research

    Published on:

  12. In June 2014 Dr. Joseph D. Fenstermacher celebrated his 80th birthday, which was honored by the symposium held in New London, NH, USA. This review discusses Fenstermacher’s contribution to the field of fluids ...

    Authors: Adam Chodobski, Jean-François Ghersi-Egea, Charles Nicholson, Tavarekere N Nagaraja and Joanna Szmydynger-Chodobska

    Citation: Fluids and Barriers of the CNS 2015 12:1

    Content type: Review

    Published on:

  13. We have recently shown that mice with experimental autoimmune encephalomyelitis (EAE) have increased sleep fragmentation (SF) and reduced sleep efficiency, and that the extent of SF correlates with the severit...

    Authors: Junyun He, Hung Hsuchou, Yi He, Abba J Kastin, Pramod K Mishra, Jidong Fang and Weihong Pan

    Citation: Fluids and Barriers of the CNS 2014 11:27

    Content type: Research

    Published on:

  14. Cefadroxil, a cephalosporin antibiotic, is a substrate for several membrane transporters including peptide transporter 2 (PEPT2), organic anion transporters (OATs), multidrug resistance-associated proteins (MR...

    Authors: Xiaomei Chen, Irena Loryan, Maryam Payan, Richard F Keep, David E Smith and Margareta Hammarlund-Udenaes

    Citation: Fluids and Barriers of the CNS 2014 11:25

    Content type: Research

    Published on:

  15. Incidental white matter hyperintensities (WMHs) are common findings on T2-weighted magnetic resonance images of the aged brain and have been associated with cognitive decline. While a variety of pathogenic mechan...

    Authors: Valerie C Anderson, James T Obayashi, Jeffrey A Kaye, Joseph F Quinn, Phillip Berryhill, Louis P Riccelli, Dean Peterson and William D Rooney

    Citation: Fluids and Barriers of the CNS 2014 11:24

    Content type: Research

    Published on:

  16. A tool for standardized and repeated neuropsychological assessments in patients with idiopathic normal pressure hydrocephalus (INPH) is needed. The objective of this study was to develop a computerized neurops...

    Authors: Anders Behrens, Anders Eklund, Eva Elgh, Cynthia Smith, Michael A Williams and Jan Malm

    Citation: Fluids and Barriers of the CNS 2014 11:22

    Content type: Research

    Published on:

  17. Limiting expansion of the ischemic core lesion by reinstating blood flow and protecting the penumbral cells is a priority in acute stroke treatment. However, at present, methods are not available for effective...

    Authors: Tavarekere N Nagaraja, Kelly A Keenan, Madhava P Aryal, James R Ewing, Saarang Gopinath, Varun S Nadig, Sukruth Shashikumar and Robert A Knight

    Citation: Fluids and Barriers of the CNS 2014 11:21

    Content type: Research

    Published on:

  18. Idiopathic normal pressure hydrocephalus (iNPH) is one of few types of dementia that can be treated with shunt surgery and cerebrospinal fluid (CSF) diversion. It is frequently present with cerebral vasculopat...

    Authors: Per Kristian Eide and Are Hugo Pripp

    Citation: Fluids and Barriers of the CNS 2014 11:19

    Content type: Short paper

    Published on:

  19. This article reviews current knowledge of the mechanisms underlying the initial hemorrhage and secondary blood–brain barrier (BBB) dysfunction in primary spontaneous intracerebral hemorrhage (ICH) in adults. M...

    Authors: Richard F Keep, Ningna Zhou, Jianming Xiang, Anuska V Andjelkovic, Ya Hua and Guohua Xi

    Citation: Fluids and Barriers of the CNS 2014 11:18

    Content type: Review

    Published on:

  20. Brinker et al. extensively reviewed recent findings about CSF circulation in a recent article: “A new look at cerebrospinal circulation”, but did not analyze some important available data in sufficient detail. Fo...

    Authors: Darko Orešković and Marijan Klarica

    Citation: Fluids and Barriers of the CNS 2014 11:16

    Content type: Commentary

    Published on:

  21. Glutaric acid (GA) is a dicarboxylic acid that accumulates in millimolar concentrations in glutaric acidemia I (GA-I), an inherited neurometabolic childhood disease characterized by extensive neurodegeneration...

    Authors: Eugenia Isasi, Luis Barbeito and Silvia Olivera-Bravo

    Citation: Fluids and Barriers of the CNS 2014 11:15

    Content type: Research

    Published on:

  22. Highly abundant proteins in biological fluids such as serum or cerebrospinal fluid (CSF) can hinder the detection of proteins in lower abundance, e.g., potential biomarkers. Commercial products are available for ...

    Authors: Ramona Günther, Eberhard Krause, Michael Schümann, Jérome Ausseil, Jean-Michel Heard, Ingolf E Blasig and Reiner F Haseloff

    Citation: Fluids and Barriers of the CNS 2014 11:14

    Content type: Short paper

    Published on:

  23. This editorial announces a new affiliation between Fluids and Barriers of the CNS (FBCNS) and the International Brain Barriers Society (IBBS) with mutual benefits to the journal and to society members. This is a ...

    Authors: Lester R Drewes, Hazel C Jones and Richard F Keep

    Citation: Fluids and Barriers of the CNS 2014 11:13

    Content type: Editorial

    Published on:

  24. Many aspects of CSF dynamics are poorly understood due to the difficulties involved in quantification and visualization. In particular, there is debate surrounding the route of CSF drainage. Our aim was to qua...

    Authors: Lucy A Murtha, Qing Yang, Mark W Parsons, Christopher R Levi, Daniel J Beard, Neil J Spratt and Damian D McLeod

    Citation: Fluids and Barriers of the CNS 2014 11:12

    Content type: Research

    Published on:

  25. The lack of absorption of CSF at the vertex in chronic hydrocephalus has been ascribed to an elevation in the arachnoid granulation outflow resistance (Rout). The CSF infusion studies measuring Rout are dependent...

    Authors: Grant A Bateman and Sabbir H Siddique

    Citation: Fluids and Barriers of the CNS 2014 11:11

    Content type: Research

    Published on:

  26. According to the traditional understanding of cerebrospinal fluid (CSF) physiology, the majority of CSF is produced by the choroid plexus, circulates through the ventricles, the cisterns, and the subarachnoid ...

    Authors: Thomas Brinker, Edward Stopa, John Morrison and Petra Klinge

    Citation: Fluids and Barriers of the CNS 2014 11:10

    Content type: Review

    Published on:

  27. Idiopathic normal pressure hydrocephalus (iNPH) is a treatable cause of dementia, gait disturbance, and urinary incontinence in elderly patients with ventriculomegaly. Its unique morphological feature, called ...

    Authors: Namiko Nishida, Nanae Nagata, Hiroki Toda, Naoto Jingami, Kengo Uemura, Akihiko Ozaki, Mitsuhito Mase, Yoshihiro Urade, Sadayuki Matsumoto, Koichi Iwasaki and Masatsune Ishikawa

    Citation: Fluids and Barriers of the CNS 2014 11:9

    Content type: Research

    Published on:

  28. Cerebrovascular complications involving endothelial dysfunction at the blood-brain barrier (BBB) are central to the pathogenesis of diabetes-related CNS disorders. However, clinical and experimental studies ha...

    Authors: Ravi K Sajja, Shikha Prasad and Luca Cucullo

    Citation: Fluids and Barriers of the CNS 2014 11:8

    Content type: Research

    Published on:

  29. The chemokine CCL2 is a critical mediator of neuroinflammation in diseases such as multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). CCL2 drives mononuclear cell in...

    Authors: Bandana Shrestha, Shujun Ge and Joel S Pachter

    Citation: Fluids and Barriers of the CNS 2014 11:6

    Content type: Short paper

    Published on:

  30. Cerebrospinal fluid absorption (CSF) at the cribriform plate is mediated by direct extracranial connections to the lymphatic system. Given the accessibility of these pharmacologically responsive vessels we hyp...

    Authors: Harold Kim, Sara A Moore and Miles G Johnston

    Citation: Fluids and Barriers of the CNS 2014 11:4

    Content type: Short paper

    Published on:

  31. Primary infection with or reactivation of varicella zoster virus (VZV) can cause neurologic complications, which typically result in an intrathecal production of VZV-specific antibodies. Intrathecal antibodies...

    Authors: Carolin Otto, Jörg Hofmann, Carsten Finke, Mathias Zimmermann and Klemens Ruprecht

    Citation: Fluids and Barriers of the CNS 2014 11:3

    Content type: Short paper

    Published on:

  32. The neuroepithelia of the choroid plexus (CP) in the brain and the ciliary body (CB) of the eye have common embryological origins and share similar micro-structure and functions. The CP epithelium (CPE) and th...

    Authors: Sarah F Janssen, Theo GMF Gorgels, Jacoline B ten Brink, Nomdo M Jansonius and Arthur AB Bergen

    Citation: Fluids and Barriers of the CNS 2014 11:2

    Content type: Research

    Published on:

  33. Magnetic resonance imaging (MRI) cardiac gated phase contrast (PC) cine techniques have non-invasively shown the effect of the cardiac pulse on cerebrospinal fluid (CSF) movement. Echo planar imaging (EPI) has...

    Authors: Shinya Yamada, Mitsue Miyazaki, Yuichi Yamashita, Cheng Ouyang, Masao Yui, Masao Nakahashi, Seiko Shimizu, Ikuo Aoki, Yukuo Morohoshi and James Gordon McComb

    Citation: Fluids and Barriers of the CNS 2013 10:36

    Content type: Research

    Published on:

  34. Mouse models are commonly used to study central nervous system disorders, in which cerebrospinal fluid (CSF) drainage may be disturbed. However, mouse CSF drainage into lymphatics has not been thoroughly chara...

    Authors: Emily Mathieu, Neeru Gupta, R Loch Macdonald, Jinglu Ai and Yeni H Yücel

    Citation: Fluids and Barriers of the CNS 2013 10:35

    Content type: Short paper

    Published on:

  35. In hydrocephalus an imbalance between production and absorption of cerebrospinal fluid (CSF) results in fluid accumulation, compression and stretching of the brain parenchyma. In addition, changes in CSF compo...

    Authors: Irum Naureen, Khawaja AIrfan Waheed, Ahsen W Rathore, Suresh Victor, Conor Mallucci, John R Goodden, Shahid N Chohan and Jaleel A Miyan

    Citation: Fluids and Barriers of the CNS 2013 10:34

    Content type: Research

    Published on:

  36. Reliable human in vitro blood–brain barrier (BBB) models suitable for high-throughput screening are urgently needed in early drug discovery and development for assessing the ability of promising bioactive compoun...

    Authors: Daniela E Eigenmann, Gongda Xue, Kwang S Kim, Ashlee V Moses, Matthias Hamburger and Mouhssin Oufir

    Citation: Fluids and Barriers of the CNS 2013 10:33

    Content type: Research

    Published on:

  37. Fibroblast growth factor (FGF)-19, an endocrine FGF protein mainly produced by the ileum, stimulates metabolic activity and alleviates obesity. FGF19 modulates metabolism after either intravenous or intracereb...

    Authors: Hung Hsuchou, Weihong Pan and Abba J Kastin

    Citation: Fluids and Barriers of the CNS 2013 10:32

    Content type: Research

    Published on:

  38. Elevated uric acid (UA) is commonly associated with gout and it is also a known cardiovascular disease risk factor. In contrast to such deleterious effects, UA possesses neuroprotective properties in the brain...

    Authors: Naoko H Tomioka, Makiko Nakamura, Masaru Doshi, Yoshiharu Deguchi, Kimiyoshi Ichida, Takayuki Morisaki and Makoto Hosoyamada

    Citation: Fluids and Barriers of the CNS 2013 10:31

    Content type: Research

    Published on:

  39. Chemokines and cytokines in cerebrospinal fluid (CSF) and serum have been extensively studied in adults with neuroborreliosis (NB), whereas there are limited data about the pediatric population. In adults, T h...

    Authors: Zuzana Liba, Jana Kayserova and Vladimir Komarek

    Citation: Fluids and Barriers of the CNS 2013 10:30

    Content type: Short paper

    Published on:

  40. Organic anion transporting polypeptide (Oatp) transporters at the blood–brain barrier (BBB) and the blood-retinal barrier (BRB), which consists of retinal capillary endothelial cells and retinal pigment epithe...

    Authors: Shin-ichi Akanuma, Shiro Hirose, Masanori Tachikawa and Ken-ichi Hosoya

    Citation: Fluids and Barriers of the CNS 2013 10:29

    Content type: Research

    Published on:

  41. The human cerebral microvascular endothelial cell line, hCMEC/D3, has been used extensively to model the blood–brain barrier (BBB) in vitro. Recently, we reported that cytokine-treatment induced loss of brain end...

    Authors: Miguel Alejandro Lopez-Ramirez, David Kingsley Male, Chunfang Wang, Basil Sharrack, Dongsheng Wu and Ignacio Andres Romero

    Citation: Fluids and Barriers of the CNS 2013 10:27

    Content type: Short paper

    Published on: