Fig. 11

Effect of the previous extent of BBB disruption on secondary BBB insults. Note that a delayed opening of the BBB after an earlier disruption translates into venous S100B levels that are inversely proportional to the extent of the earlier episode. In other words, a supramaximal increase in BBB release of S1000B appears to deplete the brain sources, allowing only a minimal release of S100B by a subsequent episode. See sections “Results” and “Discussion”