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Table 1 Advantages and disadvantages of microdialysis and microperfusion

From: Microdialysis and microperfusion electrodes in neurologic disease monitoring

  Microdialysis Microperfusion
Advantages Strong literature foundation
Able to target specific molecular weights
Single pump configuration
Less well characterized
Largely avoids biofouling
Collects biomarkers of all sizes
Simple probe construction
Simple sterilization process
Disadvantages Membrane biofouling
Complicated probe construction
Lack of commercial membrane sizes
Membrane expense
Membrane sterilization challenges
Tissue damage at high flow rates
Secondary pull pump required