Ion channel diversity, channel expression and function in the choroid plexuses

Table 1 Ion channel expression in choroid plexus epithelial cells.

	Molecular Identity	Functional evidence	References
K ⁺ channels	Not determined	Ca²⁺-activated K⁺ (Amphibia; WC;SC)	[56-58]
	Kv1.1, Kv1.3, Kv1.6	Outward rectifying conductance (WC)	[65, 69]
	Kir 7.1	Inward-rectifying current (WC)	[65, 66]
	Kir3.4	None (WC)	[68]
	TASK1	Not determined	[75]
Anion channels	Unknown	Inward-rectifying conductance (WC)	[79, 85]
	Unknown	Volume-sensitive conductance (WC)	[80]
Na ⁺ channels	ENaC	None (WC)	[90]
Ca ²⁺ channels	Unknown	Receptor-activated Ca²⁺ influx (fura2)	[27, 92]
Receptor-operated channels	P2X	Not Determined	[94, 95]
TRP channels	TRPV4	Stretch-activated, non-selective cation channel in Necturus (SC).	[59, 98, 99]
	TRPM3	Non-selective conductance (WC)	[101, 103]
Aquaporin-1	AQP1	cGMP-activated, non-selective cation channel activated (WC)	[104]

WC = recorded by whole cell methods; SC = single channel recording; fura2 measurement of intracellular Ca²⁺ activity; None = significant currents have not been observed in electrophysiological experiments; Not determined = the appropriate molecular identification or electrophysiological experiment has yet to be performed; unknown = the molecular identity of the channel protein is not known.

ISSN: 2045-8118