Skip to main content

Efficacy and safety of propiverine in cpomparison to oxybutynin in children with neurogenic detrusor overactivity: an observational study

Background

Assessment of efficacy and safety of propiverine (prop.; Mictonetten™) and oxybutynin (oxy.) in children with neurogenic detrusor overactivity (NDO) aged 1 – 18 years.

Materials and methods

In a comparative cohort study 255 children with NDO (199 myelomeningocele (MMC), 46 spinal cord injury), were treated with anticholinergics for 2.5 years on average at 14 centers and were evaluated retrospectively. 127/255 children were allocated to prop., 128/255 to oxy.; median age at diagnosis and treatment initiation were 2.08 and 7.18 (prop.) vs. 3.37 and 7.98 (oxy) years, respectively.

Results

Primary efficacy outcome, max. detrusor pressure at micturition, was on average reduced to a significantly larger extent in the prop. than in the oxy. group. Correspondingly, clinically relevant reductions of detrusor pressure (below 40 cm H20 or reduction by > 50%) resulted significantly more often in the prop. than in the oxy. group (74% vs. 50%). Urodynamic results are in agreement with clinical findings (tab. 1).

Table 1 Efficacy

Both propiverine and oxybutynin demonstrated a resolution or downgrading of vesico-uretero-renal reflux (tab. 2).

Table 2 Reflux

Propiverine was better tolerated than oxybutynin (9.40 vs. 17.46% adverse events), in those children suffering from MMC significantly better.

Conclusion

Comparative studies of efficacy and tolerability of anticholinergics in NDO of children were missing so far. This cohort study demonstrates a more effective reduction of the max. detrusor pressure at micturition with prop. in comparison to oxy. Prop. was better tolerated than oxy. Urodynamic effects are correlated with improvement of reflux, indicating possibly more favourable long-term outcomes of the upper urinary tract

Author information

Affiliations

Authors

Corresponding author

Correspondence to J Nounla.

Rights and permissions

Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution License ( https://creativecommons.org/licenses/by/2.0 ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Reprints and Permissions

About this article

Cite this article

Nounla, J., Rolle, U., Madersbacher, H. et al. Efficacy and safety of propiverine in cpomparison to oxybutynin in children with neurogenic detrusor overactivity: an observational study. Fluids Barriers CNS 2, S27 (2005). https://doi.org/10.1186/1743-8454-2-S1-S27

Download citation

Keywords

  • Spinal Cord
  • Cohort Study
  • Urinary Tract
  • Spinal Cord Injury
  • Clinical Finding