Articles
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Citation: Cerebrospinal Fluid Research 2010 7(Suppl 1):S2
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Role of hemagglutinin esterase protein in neurological manifestation of COVID-19
Citation: Fluids and Barriers of the CNS 2021 18:39 -
Familial idiopathic normal pressure hydrocephalus
Citation: Fluids and Barriers of the CNS 2015 12(Suppl 1):O43 -
More advanced Alzheimer's disease may be associated with a decrease in cerebrospinal fluid pressure
In a recent article, elevated cerebrospinal fluid pressure (CSFP) consistent with very early normal pressure hydrocephalus (NPH), was found in a small subset of Alzheimer's disease (AD) patients (possible AD-N...
Citation: Cerebrospinal Fluid Research 2009 6:14 -
Li JK: Neural Tube Defects – From Origin to Treatment Edited by: Diego F Wyszynski. Oxford University Press, New York; 2006.
Citation: Cerebrospinal Fluid Research 2006 3:6 -
Alterations in choroid plexus gene expression in Alzheimer’s disease provide inferences for CSF composition and dynamics
Citation: Cerebrospinal Fluid Research 2010 7(Suppl 1):S48 -
Erratum to: The Wisconsin Hydrocephalus Survey: shunt-dependent hydrocephalus management style among members of the American Society of Pediatric Neurosurgeons
Citation: Fluids and Barriers of the CNS 2017 14:21 -
Correction to: Correlation of CSF flow using phase-contrast MRI with ventriculomegaly and CSF opening pressure in mucopolysaccharidoses
After publication of the article [1], it has been brought to our attention that the full funding acknowledgement is missing from the original article.
Citation: Fluids and Barriers of the CNS 2017 14:28 -
Correction to: A26 Cerebrospinal fluid outflow resistance is increased following small-moderate ischaemic stroke
After publication of this supplement [1], it was brought to our attention that in the results the line “(0.3 ± 0.04 mmHg/μl/min, and 0.54 ± 0.04 mmHg/μl/min, respectively)” should actually read “(0.54 ± 0.04 m...
Citation: Fluids and Barriers of the CNS 2019 16:22 -
Correction to: An isogenic neurovascular unit model comprised of human induced pluripotent stem cell-derived brain microvascular endothelial cells, pericytes, astrocytes, and neurons
Following publication of the original article [1], the author has reported that in Figure 1 (b and c) the y-axis TEER (© x cm2) should be replaced with TEER (Ω x cm2).
Citation: Fluids and Barriers of the CNS 2019 16:31 -
Characteristic abnormalities in cerebrospinal fluid biochemistry in children with cerebral malaria compared to viral encephalitis
In developing countries where Plasmodium falciparum malaria is endemic, viral encephalitis and cerebral malaria are found in the same population, and parasitemia with Plasmodium falciparum is common in asymptomat...
Citation: Cerebrospinal Fluid Research 2006 3:8 -
Cerebrospinal fluid pulse pressure amplitude during lumbar infusion in idiopathic normal pressure hydrocephalus can predict response to shunting
We have previously seen that idiopathic normal pressure hydrocephalus (iNPH) patients having elevated intracranial pressure (ICP) pulse amplitude consistently respond to shunt surgery. In this study we explore...
Citation: Cerebrospinal Fluid Research 2010 7:5 -
Aquaporin-4 expression in the cerebrospinal fluid in congenital human hydrocephalus
Aquaporin-4 (AQP4) is a water channel mainly located in the ventricular ependymal cells (brain-CSF barrier), the sub-ependymal glia, glia limitans and in end-feet of astrocytes in at the blood–brain barrier (B...
Citation: Fluids and Barriers of the CNS 2013 10:18 -
Effect of resting pressure on the estimate of cerebrospinal fluid outflow conductance
A lumbar infusion test is commonly used as a predictive test for patients with normal pressure hydrocephalus and for evaluation of cerebrospinal fluid (CSF) shunt function. Different infusion protocols can be ...
Citation: Fluids and Barriers of the CNS 2011 8:15 -
Effects of cerebrovascular disease on amyloid precursor protein metabolites in cerebrospinal fluid
Alzheimer's disease (AD) and cerebrovascular disease (CVD) including chronic small vessel disease of the brain (SVD) are the most frequent causes of dementia. AD is associated with metabolism of amyloid precur...
Citation: Cerebrospinal Fluid Research 2010 7:10 -
Expression of TRPM8 in the distal cerebrospinal fluid-contacting neurons in the brain mesencephalon of rats
It has been shown that distal cerebrospinal fluid-contacting neurons (dCSF-CNs) exist near the ventral midline of the midbrain aqueduct and also in the grey matter of the inferior third ventricle and the fourt...
Citation: Cerebrospinal Fluid Research 2009 6:3 -
The value of the cerebrospinal fluid tap test for predicting shunt effectiveness in idiopathic normal pressure hydrocephalus
The cerebrospinal fluid (CSF) tap test (TT) has been regarded as an important test for the prediction of shunt effectiveness in patients with suspected idiopathic normal pressure hydrocephalus (iNPH). Although...
Citation: Fluids and Barriers of the CNS 2012 9:1 -
Lifestyle in adults aged 35 years who were born with open spina bifida: prospective cohort study
From 1963 to 1971, 117 babies with open spina bifida were treated non-selectively from birth. In 2002 we reviewed all the survivors by postal questionnaire and telephone call. The aims were to find out how man...
Citation: Cerebrospinal Fluid Research 2004 1:4 -
Detection of viral antigen, IgM and IgG antibodies in cerebrospinal fluid of Chikungunya patients with neurological complications
During Chikungunya virus (CHIKV) epidemic in Nagpur, India, we identified some suspected Chikungunya patients with neurological complications. Early and cost-effective diagnosis of these patients remains probl...
Citation: Cerebrospinal Fluid Research 2010 7:12 -
Cerebrospinal fluid leakage after radioisotope cisternography is not influenced by needle size at lumbar puncture in patients with intracranial hypotension
Radioisotope (RI) cisternography is considered to be the most important examination for the final diagnosis of intracranial hypotension, typically indicating cerebrospinal fluid (CSF) leakage as RI parathecal ...
Citation: Cerebrospinal Fluid Research 2009 6:5 -
Cerebrospinal fluid matrix metalloproteinase-9 increases during treatment of recurrent malignant gliomas
Matrix metalloproteinases (MMPs) are enzymes that promote tumor invasion and angiogenesis by enzymatically remodeling the extracellular matrix. MMP-2 and MMP-9 are the most abundant forms of MMPs in malignant ...
Citation: Cerebrospinal Fluid Research 2008 5:1 -
Th1 and Th17 but no Th2-related cytokine spectrum in the cerebrospinal fluid of children with Borrelia-related facial nerve palsy
Chemokines and cytokines in cerebrospinal fluid (CSF) and serum have been extensively studied in adults with neuroborreliosis (NB), whereas there are limited data about the pediatric population. In adults, T h...
Citation: Fluids and Barriers of the CNS 2013 10:30 -
Temporal course of cerebrospinal fluid dynamics and amyloid accumulation in the aging rat brain from three to thirty months
Amyloid accumulation in the brain parenchyma is a hallmark of Alzheimer's disease (AD) and is seen in normal aging. Alterations in cerebrospinal fluid (CSF) dynamics are also associated with normal aging and A...
Citation: Fluids and Barriers of the CNS 2012 9:3 -
Delamination technique together with longitudinal incisions for treatment of Chiari I/syringomyelia complex: a prospective clinical study
Treatment modalities in Chiari malformation type 1(CMI) accompanied by syringomyelia have not yet been standardized. Pathologies such as a small posterior fossa and thickened dura mater have been discussed pre...
Citation: Cerebrospinal Fluid Research 2009 6:7 -
Sustained choroid plexus function in human elderly and Alzheimer’s disease patients
We and other investigators have postulated deterioration of essential choroid plexus (CP) functions in some elderly and especially Alzheimer’s disease patients based on apparent anatomical, histological and pa...
Citation: Fluids and Barriers of the CNS 2013 10:28 -
Fibroblast growth factor 19 entry into brain
Fibroblast growth factor (FGF)-19, an endocrine FGF protein mainly produced by the ileum, stimulates metabolic activity and alleviates obesity. FGF19 modulates metabolism after either intravenous or intracereb...
Citation: Fluids and Barriers of the CNS 2013 10:32 -
Fibrinogen is not elevated in the cerebrospinal fluid of patients with multiple sclerosis
Elevated plasma fibrinogen levels are a well known finding in acute infectious diseases, acute stroke and myocardial infarction. However its role in the cerebrospinal fluid (CSF) of acute and chronic central (...
Citation: Fluids and Barriers of the CNS 2011 8:25 -
Removal of albumin and immunoglobulins from canine cerebrospinal fluid using depletion kits: a feasibility study
Highly abundant proteins in biological fluids such as serum or cerebrospinal fluid (CSF) can hinder the detection of proteins in lower abundance, e.g., potential biomarkers. Commercial products are available for ...
Citation: Fluids and Barriers of the CNS 2014 11:14 -
Risk factors for pressure sores in adult patients with myelomeningocele – a questionnaire-based study
Myelomeningocele (MMC) is a part of a complex neural tube defect and a disorder of the cerebrospinal fluid system. Pressure sores are a frequent complication for patients with MMC. Little is known about the ri...
Citation: Cerebrospinal Fluid Research 2006 3:14 -
Evidence for reduced lymphatic CSF absorption in the H-Tx rat hydrocephalus model
There is mounting evidence that spinal fluid absorption takes place not only at the arachnoid villi, but also at several extracranial sites, which might serve as a reserve mechanism for, or be primarily involv...
Citation: Cerebrospinal Fluid Research 2008 5:15 -
Turnover rate of cerebrospinal fluid in female sheep: changes related to different light-dark cycles
Sheep are seasonal breeders. The key factor governing seasonal changes in the reproductive activity of the ewe is increased negative feedback of estradiol at the level of the hypothalamus under long-day condit...
Citation: Cerebrospinal Fluid Research 2009 6:9 -
Prostaglandin E2metabolism in rat brain: Role of the blood-brain interfaces
Prostaglandin E2 (PGE2) is involved in the regulation of synaptic activity and plasticity, and in brain maturation. It is also an important mediator of the central response to inflammatory challenges. The aim of ...
Citation: Cerebrospinal Fluid Research 2008 5:5 -
A new look at cerebrospinal fluid movement
Brinker et al. extensively reviewed recent findings about CSF circulation in a recent article: “A new look at cerebrospinal circulation”, but did not analyze some important available data in sufficient detail. Fo...
Citation: Fluids and Barriers of the CNS 2014 11:16 -
Bacterial melanin crosses the blood–brain barrier in rat experimental model
Bacterial melanin has been proven to stimulate regeneration after CNS lesions. The purpose of this study was to test, whether bacterial melanin can enter the brain via the blood–brain barrier (BBB).
Citation: Fluids and Barriers of the CNS 2014 11:20 -
Increased CSF osmolarity reversibly induces hydrocephalus in the normal rat brain
Hydrocephalus is a central nervous system (CNS) disorder characterized by the abnormal accumulation of cerebrospinal fluid (CSF) in cerebral ventricles, resulting in their dilatation and associated brain tissu...
Citation: Fluids and Barriers of the CNS 2012 9:13 -
An experimental in-vivo canine model for adult shunt infection
Detailed human studies of the mechanisms and development of shunt infection in real time are not possible, and we have developed a canine hydrocephalus model to overcome this. The intention of this pilot study...
Citation: Cerebrospinal Fluid Research 2008 5:17 -
Transfer of rhodamine-123 into the brain and cerebrospinal fluid of fetal, neonatal and adult rats
Adenosine triphosphate binding cassette transporters such as P-glycoprotein (PGP) play an important role in drug pharmacokinetics by actively effluxing their substrates at barrier interfaces, including the blo...
Citation: Fluids and Barriers of the CNS 2021 18:6 -
Neonatal high pressure hydrocephalus is associated with elevation of pro-inflammatory cytokines IL-18 and IFNγ in cerebrospinal fluid
In human neonatal high pressure hydrocephalus (HPHC), diffuse white matter injury and gliosis predispose to poor neuro-developmental outcome. The underlying mechanism for diffuse white matter damage in neonata...
Citation: Cerebrospinal Fluid Research 2008 5:21 -
Brain endothelial LRP1 maintains blood–brain barrier integrity
The entry of blood-borne molecules into the brain is restricted by the blood–brain barrier (BBB). Various physical, transport and immune properties tightly regulate molecule movement between the blood and the ...
Citation: Fluids and Barriers of the CNS 2021 18:27 -
Influence of respiration on cerebrospinal fluid movement using magnetic resonance spin labeling
Magnetic resonance imaging (MRI) cardiac gated phase contrast (PC) cine techniques have non-invasively shown the effect of the cardiac pulse on cerebrospinal fluid (CSF) movement. Echo planar imaging (EPI) has...
Citation: Fluids and Barriers of the CNS 2013 10:36 -
Possible role of the cavernous sinus veins in cerebrospinal fluid absorption
The purpose of this investigation was to enhance our understanding of cerebrospinal fluid (CSF) absorption pathways. To achieve this, Microfil (a coloured silastic material) was infused into the subarachnoid s...
Citation: Cerebrospinal Fluid Research 2007 4:3 -
Casey Memorial Lectureship :Adult consequences of spina bifida
Citation: Cerebrospinal Fluid Research 2005 2(Suppl 1):S44 -
Commentary on human pluripotent stem cell-based blood–brain barrier models
In 2012, we provided the first published evidence that human pluripotent stem cells could be differentiated to cells exhibiting markers and phenotypes characteristic of the blood–brain barrier (BBB). In the en...
Citation: Fluids and Barriers of the CNS 2020 17:64 -
Cerebrospinal fluid markers before and after shunting in patients with secondary and idiopathic normal pressure hydrocephalus
The aim of this study was to explore biochemical changes in the cerebrospinal fluid (CSF) induced by shunt surgery and the relationship between these changes and clinical improvement.
Citation: Cerebrospinal Fluid Research 2008 5:9 -
Mannan-binding lectin in cerebrospinal fluid: a leptomeningeal protein
Mannan-binding lectin (MBL), a protein of the innate immune response is attracting increasing clinical interest, in particularly in relation to its deficiency. Due to its involvement in brain diseases, identif...
Citation: Fluids and Barriers of the CNS 2012 9:17 -
Initial experience with the Codman Certas adjustable valve in the management of patients with hydrocephalus
A new adjustable valve, the Codman CertasTM valve for treatment of hydrocephalus was introduced into clinical practice in January 2011. It has 8 different settings with an opening pressure varying from 36 to over...
Citation: Fluids and Barriers of the CNS 2012 9:21 -
Cerebrospinal fluid analysis in 108 patients with progressive multifocal leukoencephalopathy
Progressive multifocal leukoencephalopathy (PML) is caused by an opportunistic infection with JC polyoma virus (JCPyV) and mainly affects immunocompromised patients. It leads to pronounced demyelination of the...
Citation: Fluids and Barriers of the CNS 2020 17:65 -
Evaluation of the IS6110 PCR assay for the rapid diagnosis of tuberculous meningitis
Tuberculous meningitis (TBM) is one of the common clinical manifestations of extra-pulmonary tuberculosis. It is difficult to diagnose due to a lack of rapid, sensitive, and specific tests. Newer methods, whic...
Citation: Cerebrospinal Fluid Research 2007 4:10 -
Extrapyramidal signs in normal pressure hydrocephalus: an objective assessment
Beyond the classic Normal Pressure Hydrocephalus (NPH) triad of gait disturbance, incontinence, and dementia are characteristic signs of motor dysfunction in NPH patients. We used highly sensitive and objectiv...
Citation: Cerebrospinal Fluid Research 2007 4:7 -
The fraction of varicella zoster virus-specific antibodies among all intrathecally-produced antibodies discriminates between patients with varicella zoster virus reactivation and multiple sclerosis
Primary infection with or reactivation of varicella zoster virus (VZV) can cause neurologic complications, which typically result in an intrathecal production of VZV-specific antibodies. Intrathecal antibodies...
Citation: Fluids and Barriers of the CNS 2014 11:3