Cognitive decline, Aβ pathology, and blood–brain barrier function in aged 5xFAD mice

Table 7 Effect Size Estimates for In vivo Fluorescence Intensities

Effect	Estimate^a	χ² (df)	p
Age	− 0.696 ± 0.481	2.093 (1)	0.148
Age × Extravascular Compartment	0.052 ± 0.011	24.216 (1)	< 0.001
Age × Extravascular Compartment × Genotype	− 0.009 ± 0.011	0.718 (1)	0.397
Age × Extravascular Compartment × Genotype × Time	0.031 ± 0.010	9.143 (1)	0.002
Age × Genotype	0.102 ± 0.480	0.045 (1)	0.832
Age × Genotype × Time	− 0.024 ± 0.011	5.294 (1)	0.021
Age × Genotype × Tracer Size	− 0.066 ± 0.012	31.295 (1)	< 0.001
Age × Time	− 0.011 ± 0.011	1.026 (1)	0.311
Age × Tracer Size	0.018 ± 0.014	1.688 (1)	0.194
Age × Tracer Size × Time	− 0.024 ± 0.010	5.575 (1)	0.018
Extravascular Compartment	− 0.522 ± 0.011	2446.141 (1)	< 0.001
Extravascular Compartment × Genotype	− 0.033 ± 0.011	9.762 (1)	0.002
Extravascular Compartment × Genotype × Time	− 0.002 ± 0.010	0.028 (1)	0.867
Extravascular Compartment × Time	0.018 ± 0.010	3.186 (1)	0.074
Extravascular Compartment × Time	0.011 ± 0.010	1.212 (1)	0.271
Extravascular Compartment × Tracer Size × Time	0.025 ± 0.010	6.222 (1)	0.013
Extravascular Compartment × Tracer Size	0.063 ± 0.010	38.594 (1)	< 0.001
Genotype	0.325 ± 0.480	0.458 (1)	0.499
Genotype × Time	− 0.001 ± 0.011	0.018 (1)	0.894
Genotype × Tracer Size	0.024 ± 0.013	3.369 (1)	0.066
Time	0.023 ± 0.011	4.831 (1)	0.028
Tracer Size	− 0.157 ± 0.013	138.653 (1)	< 0.001
Tracer Size × Time	− 0.057 ± 0.010	31.735 (1)	< 0.001

Estimates are reported with corresponding p values, chi-squared values, and degrees of freedom
^aCalculated on a log link. Data is presented as mean values ± standard error

ISSN: 2045-8118