Cognitive decline, Aβ pathology, and blood–brain barrier function in aged 5xFAD mice

Table 3 Pairwise comparison of modeled escape latencies by age, genotype, rd1 allele status and learning rates

Modeled escape latencies by genotype
Phase	Age (m)	rd1 status	WT Mice	5xFAD Mice	p
Cued	9.5	wt/wt	17.53 ± 2.39	54.20 ± 19.44	0.061
Cued	9.5	*rd1/wt*	18.18 ± 3.00	44.18 ± 6.77	0.002
Cued	15.5	wt/wt	27.58 ± 5.51	55.66 ± 7.02	0.056
Cued	15.5	*rd1/wt*	19.81 ± 4.04	61.20 ± 11.72	0.002
Spatial	9.5	wt/wt	14.60 ± 1.99	35.73 ± 11.22	0.117
Spatial	9.5	rd1/wt	22.19 ± 3.77	27.97 ± 3.24	1.000
Spatial	15.5	wt/wt	28.04 ± 9.14	71.08 ± 10.97	0.117
Spatial	15.5	rd1/wt	29.51 ± 11.52	75.04 ± 16.54	0.396

Modeled escape latencies by age
Phase	Genotype	rd1 status	Age (9.5 m)	Age (15.5 m)	p
Cued	WT	wt/wt	17.53 ± 2.39	27.58 ± 5.51	0.651
Cued	WT	rd1/wt	18.18 ± 3.00	19.81 ± 4.04	1.000
Cued	5xFAD	wt/wt	54.20 ± 19.44	55.66 ± 7.02	1.000
Cued	5xFAD	rd1/wt	44.18 ± 6.77	61.20 ± 11.72	1.000
Spatial	WT	wt/wt	14.60 ± 1.99	28.04 ± 9.14	0.455
Spatial	WT	rd1/wt	22.19 ± 3.77	29.51 ± 11.52	1.000
Spatial	5xFAD	wt/wt	35.73 ± 11.22	71.08 ± 10.97	0.455
Spatial	5xFAD	*rd1/wt*	27.97 ± 3.24	75.04 ± 16.54	0.002

Modeled escape latencies by rd1 status
Phase	Genotype	Age (m)	wt / wt mice	rd1 / wt mice	p
Cued	WT	9.5	17.53 ± 2.39	18.18 ± 3.00	1.000
Cued	5xFAD	9.5	54.20 ± 19.44	44.18 ± 6.77	1.000
Cued	WT	15.5	27.58 ± 5.51	19.81 ± 4.04	1.000
Cued	5xFAD	15.5	55.66 ± 7.02	61.20 ± 11.72	1.000
Spatial	WT	9.5	14.60 ± 1.99	22.19 ± 3.77	0.455
Spatial	5xFAD	9.5	35.73 ± 11.22	27.97 ± 3.24	1.000
Spatial	WT	15.5	28.04 ± 9.14	29.51 ± 11.52	1.000
Spatial	5xFAD	15.5	71.08 ± 10.97	75.04 ± 16.54	1.000

Learning rates (slopes on model (log) link; s/day)
Phase	Age	WT	5xFAD	p
Cued	9.5 mo	− 0.315 ± 0.032	− 0.267 ± 0.032	0.024
Cued	15.5 mo	− 0.315 ± 0.032	− 0.267 ± 0.032	0.024
Spatial	9.5 mo	− 0.125 ± 0.015	− 0.077 ± 0.013	0.024
Spatial	15.5 mo	− 0.125 ± 0.015	− 0.077 ± 0.013	0.024

Modeled escape latencies for each group with their corresponding p values (adjusted by Benjimini-Yakuteli false discovery correction). Data is presented as mean values ± standard error. Relevant effect sizes with p < 0.05 are discussed in the results section and shown in bold text here

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