Cognitive decline, Aβ pathology, and blood–brain barrier function in aged 5xFAD mice

Table 2 Effect Size Estimates for Escape Latency in MWM test

Effect	Estimate^a	χ² (df)	p	R²
Age	0.219 ± 0.076	87.251 (1)	< 0.001	0.070
Genotype (5xFAD)	0.270 ± 0.081	17.141 (1)	< 0.001	0.127
rd1 allele	0.008 ± 0.075	0.119 (1)	0.730	0.009
Test day	− 0.196 ± 0.016	213.881 (1)	< 0.001	0.080
Test phase (Cued)	− 0.070 ± 0.074	1.094 (1)	0.296	0.078
Age × Rd1 mutation	0.009 ± 0.078	0.146 (1)	0.702	0.004
Genotype × Age	0.034 ± 0.074	2.184 (1)	0.139	0.011
Genotype × Rd1 mutation	0.028 ± 0.075	1.494 (1)	0.222	0.004
Test Day × Genotype	0.024 ± 0.010	6.912 (1)	0.009	< 0.001
Test Phase × Age	− 0.108 ± 0.032	22.783 (1)	< 0.001	0.009
Test Phase × Genotype	0.138 ± 0.045	12.419 (1)	< 0.001	0.006
Test Phase × Rd1 mutation	0.043 ± 0.029	3.595 (1)	0.058	0.003
Test Phase × Test Day	− 0.095 ± 0.016	51.594 (1)	< 0.001	0.017

Effect size estimates for escape latencies with corresponding p values (adjusted by Benjimini-Yakuteli false discovery correction), chi-squared (χ²) values, R² values, and degrees of freedom (df)
^aCalculated on log link. Data is presented as mean values ± standard error. Relevant effect sizes with p < 0.05 are discussed in the results section and shown in bold text

ISSN: 2045-8118