Fig. 9
From: Cognitive decline, Aβ pathology, and blood–brain barrier function in aged 5xFAD mice
Distribution of fluorescent-labeled dextrans in 5xFAD and WT Mice. A–D Representative MIP images from age-matched 5xFAD and WT mice for each dextran. E Intravascular sum intensity of FITC-70 kDa dextran MIP images over 70 min of in vivo imaging. F Extravascular sum intensity for FITC-70 kDa dextran MIP images. G Intravascular sum intensity of 3 kDa dextran MIP images. H Extravascular sum intensity of 3 kDa dextran. I Vessel diameters were measured from in vivo MIP images with FITC-70 kDa dextran and TR-3 kDa dextran labeled vessels. Legend: 9.5-month-old WT mice (blue hollow column), 9.5-month-old 5xFAD mice (red hollow column), 15.5-month-old WT mice (blue filled column), and 15.5-month-old 5xFAD mice (red filled column). Sample sizes for TR-3 kDa dextran-labeled vessels: 9.5-month-old WT mice (n = 9), 9.5-month-old 5xFAD mice (n = 11), 15.5-month-old WT mice (n = 12), 15.5-month-old 5xFAD mice (n = 11). Sample sizes for FITC-70 kDa dextran-labeled vessels: 9.5-month-old WT mice (n = 8), 9.5-month-old 5xFAD mice (n = 11), 15.5-month-old WT mice (n = 11), 15.5-month-old 5xFAD mice (n = 11). Error bars indicate standard errors of the mean (SEM) for each measurement