Fig. 8
From: Cognitive decline, Aβ pathology, and blood–brain barrier function in aged 5xFAD mice
In vivo Two-Photon Microscopy Imaging of 5xFAD and WT mice. A Schematic graphic showing an overview of the in vivo imaging setup. B Image showing a mouse head with an acutely installed cranial window. C Image of an anesthetized mouse secured on the microscopy board for in vivo microscopy. D MIP image of cortical vessels infused with FITC-70 kDa dextran (green). E MIP of cortical vessels infused with TR-3 kDa dextran (red). F Segmented image obtained from the Zen Intellesis module that shows intravascular (orange) and extravascular (cyan) regions