Fig. 7
From: Cognitive decline, Aβ pathology, and blood–brain barrier function in aged 5xFAD mice
Plasma and Brain Aβ levels in 5xFAD Mice. A Median plasma Aβ40 levels (ng/dL) were significantly higher for 15.5-month-old 5xFAD mice (red filled column) than 9.5-month-old 5xFAD mice (red hollow column). B Median plasma Aβ42 levels (ng/dL) were similar for 9.5-month-old 5xFAD mice (red hollow column) and 15.5-month-old 5xFAD mice (red filled column). Error bars in A and B show the interquartile range. Dashed lines indicated lower limits of quantitation. C Mean brain Aβ40 levels (ng/mg brain weight) were significantly higher for 16-month-old 5xFAD mice (red filled column) than 9.5-month-old 5xFAD mice (red hollow column). D Mean brain Aβ42 levels (ng/mg brain weight) in 9.5-month-old 5xFAD mice (red hollow column) and 15.5-month-old 5xFAD mice (red filled column). No significant differences were noted between the two groups. Red hollow circles represent individual data points. The dotted lines in A and B show the lower limit of quantitation (LLOQ) for Aβ. Error bars in A and B show the interquartile range, and errors in C and D show the standard error of the mean (SEM)