Fig. 6

Probe Trial Metrics in MWM test. A Percent time in the target quadrant (Q) for 9.5-month-old 5xFAD mice (red hollow columns), 9.5-month-old WT mice (blue hollow columns), 15.5-month-old 5xFAD mice (red filled columns), and 15.5-month-old WT mice (blue filled columns) during the probe trial duration (60 s). Time in the target quadrant decreased with age. No differences in Q values were noted between 5xFAD and age-matched WT mice. B Q values during the first 15 s of the probe trial. Q values in the first 15 s of the trial showed higher resolution when compared with Q values at the end of the trial (60 s). p values estimated on model log scales. *p = 0.05, ^#p = 0.029, ***p = 0.003. C Percentage of trials with zero time in target quadrant for all groups during the probe trial duration (60 s). D Percentage of trials with zero time in target quadrant for all groups in the first 15 s of the trial. E Normalized distance to platform (P, m/s) during probe trials. P values were similar for all groups in all probe trials. F Normalized distance to platform during the first 15 s probe trial. P values for 5xFAD mice were higher than P values for age-matched WT mice, but no differences were noted between age-matched 5xFAD and WT mice. p values estimated on model log scales. *p = 0.039, **p = 0.003, ***p < 0.001, ^#p = 0.001