Fig. 4

Search Strategy Selection of 5xFAD and WT mice. Search strategy preferences for A 9.5-month-old WT mice, B 9.5-month-old 5xFAD mice, C 15.5-month-old WT mice, and D 15.5-month-old 5xFAD mice. Data is presented as cumulative trials (% frequencies). Color legend for each strategy is presented at the top. Slopes for inter-strategy interfaces are indicated as mean ± standard errors of the mean (SEM) adjacent to each plot. For any given strategy, inter-strategy slopes were highest for 9.5-month-old WT mice, followed by 9.5-month-old 5xFAD mice, 15.5-month-old WT mice, and 15.5-month-old 5xFAD mice. E Histograms represent modeled escape latencies across search strategies mice adopt in the cued learning phase. F Histograms represent modeled escape latencies across mouse search strategies in the spatial acquisition phase. All strategies have similar escape latencies in 9.5-month-old mice. In contrast, shorter escape latencies were associated with structured strategies in 15.5-month-old mice. Rd1 mutation did not have an impact on search strategy preferences