Fig. 2
From: Cognitive decline, Aβ pathology, and blood–brain barrier function in aged 5xFAD mice
Failed trials in MWM testing and Accelerated Failure Time Modeling. A Percentage of failed trials by 9.5-month-old WTrd1/wt mice (dark blue circles), 9.5-month-old WTwt/wt mice (light blue circles), 9.5-month-old 5xFADrd1/wt mice (magenta circles), and 9.5-month-oldwt//wt mice (red circles). B Percentage of failed trials by 15.5-month-old WTrd1/wt mice (dark blue circles), 15.5-month-old WTwt/wt mice (light blue circles), 15.5-month-old 5xFADrd1/wt mice (magenta circles), and 15.5-month-oldwt//wt mice (red circles). C Modeled escape latencies for 9.5-month-old WTrd1/wt mice (dark blue line), 9.5-month-old WTwt/wt mice (light blue line), 9.5-month-old 5xFADrd1/wt mice (magenta line), and 9.5-month-old wt//wt mice (red line). D) Modeled escape latencies for 15.5-month-old WTrd1/wt mice (dark blue line), 15.5-month-old WTwt/wt mice (light blue line), 15.5-month-old 5xFADrd1/wt mice (magenta line), and 15.5-month-old wt//wt mice (red line). Modeled data is presented as model (solid line) ± 95% prediction intervals (shades). Modeled latencies increased with age and genotype and resulted in an extrapolated estimate for latencies in failed trials