Fig. 1

Learning and Spatial Memory Impairments in Aged 5xFAD and WT mice. A Schematic diagram for MWM cued learning phase, spatial acquisition phase, and MWM probe trials. B Pictures of mice searching the platform during the cued learning phase, spatial acquisition phase, and probe trial. Insert shows a mouse on the platform marked with a pole at the end of a trial. C Censored mean escape latency (s) for 9.5-month-old WT^rd1/wt mice (dark blue circles), 9.5-month-old WT^wt/wt mice (light blue circles), 9.5-month-old 5xFAD^rd1/wt mice (magenta circles), and 9.5-month-old ^wt//wt mice (red circles). D) Censored mean escape latency (s) for 15.5-month-old WT^rd1/wt mice (dark blue circles), 15.5-month-old WT^wt/wt mice (light blue circles), 15.5-month-old 5xFAD^rd1/wt mice (magenta circles), and 15.5-month-old ^wt//wt mice (red circles)