Fig. 2
From: Transient but not chronic hyperglycemia accelerates ocular glymphatic transport
Ocular glymphatic CSF influx along the optic nerve remains unchanged in diabetic mice. (A) Experimental design of CSF tracer distribution in the optic nerve after intracisternal tracer injection. (B) Representative macroscopic images of CSF tracer distribution along optic nerves of four-month diabetic or control mice. (C) Distribution of CM-injected tracer depicting glymphatic CSF influx along the entire optic nerves (distance ascending from anterior to posterior) Left: two-months, right: four-month time point after onset of STZ diabetes (n = 6–9). (D) Total CM tracer signal in the optic nerve, (E) peak signal intensity and (F) peak signal distance travelled. Distance ascending from eyeball. n = 6–9, ns = P > 0.05 between indicated groups by two-way ANOVA with Tukey’s correction. All graphs show mean ± SD