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Fig. 2 | Fluids and Barriers of the CNS

Fig. 2

From: The proteome of the blood–brain barrier in rat and mouse: highly specific identification of proteins on the luminal surface of brain microvessels by in vivo glycocapture

Fig. 2

In vivo glycocapture enriches for BBB proteins with high specificity in both rat and mouse. A Number of proteins identified in rats perfused with oxidation solution (OXY) or a buffer control (CTL) after the glycocapture workflow. B Top 50 proteins ranked by spectral counts that were identified in OXY rat samples. All proteins are listed by their corresponding HGNC gene symbol. C Number of proteins identified in a pilot mouse study perfused with oxidation solution (OXY) or a buffer control (CTL). D Top 50 proteins ranked by spectral counts identified in all OXY perfused mice. E Comparison of proteins identified by in vivo glycocapture in rat and in mouse (top) and comparison of proteins identified by in vivo glycocapture in rat with proteins identified by cell surface capture of the rat endothelial cell line, SV-ARBEC (bottom). F Classification of all proteins identified by in vivo glycocapture in either rat or mouse by Panther protein class

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Fluids and Barriers of the CNS

ISSN: 2045-8118