Fig. 1

Laminin α5 expression is ablated in endothelial and mural cells in α5-TPKO mice. A Representative images of Laminin-α5 (green) and Podocalyxin (red) staining in the cortex of 4 ∼ 6-month-old control and α5-TPKO mice (both sexes). Scale bar: 100 μm. B-D Quantification of Laminin-α5 fluorescent intensity in the cortex (B), hippocampus (C), and striatum (D). **p = 0.0079, Mann-Whitney U test. n = 5 mice. Data were shown as mean ± SD