Analysis of the contributing role of drug transport across biological barriers in the development and treatment of chemotherapy-induced peripheral neuropathy

Table 1 Overview of pharmacology and PN-centered toxicology of the selected drugs

Category	Compound	Pharmacology		Localization of a pharmacological target	Toxicology (PN)
Category	Compound	Class	Pharmacological target	Localization of a pharmacological target	Positive or negative	Target site
CIPN-positive or negative	Paclitaxel	Taxane	Tubulin	Intracellular	Positive	DRG, axon, and distal nerve termina [48]
	Vincristine	Vinca alkaloid	Tubulin	Intracellular	Positive	DRG, axon [49]
	Methotrexate	Antimetabolite	Dihydrofolate reductase Thymidylate synthase Bifunctional purine biosynthesis protein	Intracellular	Negative	N.A
	Nilotinib	Tyrosine kinase inhibitor	Tyrosine-protein kinase ABL-1^§ Mast/stem cell growth factor receptor	Intracellular^§	Negative	N.A
PN-positive or negative	Isoniazid	Antitubercular agent	Long-chain enoyl-acyl carrier protein reductase (InhA) Pyridoxal kinase^a	Intracellular	Positive	Nerve terminals [50]
	Acrylamide	N.A	N.A		Positive	Nerve terminals [51]
	Varenicline	Smoking cessation aid	α4β2 neuronal nicotinic acetylcholine receptor	Extracellular	Negative	N.A
	Oxycodone	Opioid analgesic	Opioid receptors	Extracellular	Negative	N.A
	Paroxetine	Selective serotonin-reuptake inhibitor	Serotonin reuptake transporter	Extracellular	Negative	N.A
	Monomethyl fumarate	Immunomodulatory drug	Nuclear factor erythroid 2-related factor 2	Intracellular	Negative	N.A
	Diazepam	Benzodiazepine	GABA receptor	Extracellular	Negative	N.A

ISSN: 2045-8118