Fig. 6
Scatter plots of unbound intracellular-to-extracellular concentration ratio (Kp,uu,cell) of the indicated drugs at the specified tissues. This parameter describes the extent of unbound drug transport across the cellular barriers in the DRG, SN, and Br parenchyma. A–K Measurements for the different drugs, with their CIPN and PN status indicated. Black dashed line, Kp,uu,cell = 1, indicates predominant passive diffusion or mutually compensated influx and efflux; Kp,uu,cell < 1 indicates limited intracellular entry; Kp,uu,cell > 1 indicates predominant accumulation inside the cells. Data are presented as the mean ± SD estimated using the error propagation method [51] . *p < 0.05, **p < 0.01, ***p < 0.001, or ****p < 0.0001 (ordinary one-way ANOVA with Tukey’s multiple comparison test). NB: note the differences in scale