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Fig. 5 | Fluids and Barriers of the CNS

Fig. 5

From: Analysis of the contributing role of drug transport across biological barriers in the development and treatment of chemotherapy-induced peripheral neuropathy

Fig. 5

Measurement of the unbound volume of distribution (Vu) of the indicated drugs in the specified tissues. This parameter describes both the cellular uptake and binding in the DRG, SN, and Br. A Experimental overview. B–L Scatter dot plots of Vu of the different drugs, with their CIPN and NP propensity indicated. Data are presented as the mean ± SD, n = 3–8 biological replicates (1–5 technical replicates per each biological replicate). *p < 0.05, **p < 0.01, ***p < 0.001, or ****p < 0.0001 (ordinary one-way ANOVA with Tukey’s multiple comparison test). NB: note the differences in scale

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Fluids and Barriers of the CNS

ISSN: 2045-8118