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Table 2 IPTW survival analysis estimating the HR and sHR of dementia, AD, and vascular dementia among patients with iNPH

From: Cerebrospinal fluid shunt surgery reduces the risk of developing dementia and Alzheimer’s disease in patients with idiopathic normal pressure hydrocephalus: a nationwide population-based propensity-weighted cohort study

Outcomes

Number of patients

Event

Person years

Incidence rate†

HR (95% CI)

sHR (95% CI)

Dementia

 Non-shunt surgery

1677.4

294.3

7152.4

41.2

1

1

 Shunt surgery

375.0

49.1

1432.1

34.3

0.83 (0.61, 1.12)

0.74 (0.55, 0.99)*

Alzheimer's disease

 Non-shunt surgery

1677.4

60.0

7807.6

7.7

1

1

 Shunt surgery

375.0

2.0

1556.8

1.3

0.17 (0.04, 0.69)*

0.15 (0.04, 0.61)*

Vascular dementia

 Non-shunt surgery

1677.4

20.9

7921.3

2.6

1

1

 Shunt surgery

375.0

4.9

1550.5

3.2

1.18 (0.44, 3.16)

1.07 (0.40, 2.86)

  1. IPTW, inverse probability of treatment weighting. iNPH, idiopathic normal-pressure hydrocephalus. †, per 1000 person-years. HR, hazard ratio obtained from Cox proportional hazards regression analysis. sHR, subdistribution hazard ratio obtained from Fine–Gray subdistribution hazard competing risk regression analysis. *, p < 0.05