Table 2 Proteins of potential interest

Malignancy

 Catalase (increases)

CNS-ALL

(1) Occurs in aerobically respiring cells (indicating hypoxic glycolysis)

(2) Promotes growth of leukemic cells

 Melanoma-derived growth regulatory protein (increases)

Glioma

Infrequently expressed in glioma. Expression correlate with lower progression rates

 Gamma-enolase (increases)

Brain tumors

Known to increase in various tumors

 Kallikrein-6 (increases)

Metastasizing/infiltration

Degrades extracellular matrix, facilitating ease of infiltration

Adverse events

 Amyloid-like protein 2 (decrease)

Plasminogen (decrease)

Histidine-rich glycoprotein (decrease)

Thromboemobolism

Amyloid-like protein 2 exert inhibitory effects on coagulations factors

Plasminogen and Histidine-rich glycoprotein deficiencies are prothombotic due to hypofibrinolysis

 Apolipoprotein E (increase)

Calsyntenin-1 (increase)

Glypican-1 (increase)

Disintegrin and metalloproteinase domain-containing protein 10 (increase)

Spectrin beta chain brain 2 (increase)

Prosaposin receptor GPR37 (increase)

Sodium/potassium-transporting ATPase subunit alpha-3 (increase)

Triosephosphate isomerase (decrease)

Progesteron-induced blocking factor 1 (decrease)

Neurotoxicity—involved in pathogenesis of neurodegenerative diseases or neuromuscular dysfinction

Alzheimer: Apolipoprotein E, Calsyntenin-1, Glypican-1, Disintegran metalloproteinase domain-containing protein 10

Parkinsonism: Ceruloplasmin, Sodium/potassium-transporting ATPase subunit alpha-3 and Prosaposin receptor GPR37 (juvenile Parkinson)

Neuromuscular dysfunction: Spectrin beta chain brain 2, Sodium/potassium-transporting ATPase subunit alpha-3

 Neuromodulin (increase)

Gamma-enolase (increase)

Prosaposin receptor GPR37 (increase)

Prostaglanding-H2 D-isomerase (increase)

Immunoglobulin superfamily member 8 (increase)

Kallikrein-6 (increase)

Neuroprotective properties (as measure of neurotoxicity)