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Fig. 7 | Fluids and Barriers of the CNS

Fig. 7

From: CSF hyperdynamics in rats mimicking the obesity and androgen excess characteristic of patients with idiopathic intracranial hypertension

Fig. 7

CSF flow determination in lean and testosterone treated obese Zucker rats. A Representative images of lean (top) and testosterone-treated obese (obese + TT, bottom) rats after (t = 30 s, left panels and t = 5 min, right panels) injection of IRDye 800CW carboxylate dye (superimposed pseudo-color). The dotted lines represent the lambda line, and image areas represent the area of dye quantification. B The dye intensity normalized to that obtained in the first image and plotted as a function of time, n = 5 of each group. C Quantification of the dye intensity as a function of time (the flow rate) determined from linear regression in B over the 5 min time window, n = 5 of each group. D Correlation of the CSF flow rate as a function of bodyweight, n = 5. Statistical significance evaluated with Student’s unpaired t-test or simple linear regression and results shown as mean ± SEM. ***p < 0.001

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Fluids and Barriers of the CNS

ISSN: 2045-8118