Fig. 6
Intracranial pressure of testosterone-treated obese Zucker rats. A representative intracranial pressure (ICP) traces from lean and testosterone-treated obese (Obese + TT) Zucker rats with the final 15 min recordings quantified in B, n = 5 of each. C Correlation analysis of ICP as a function of bodyweight in the tested Zucker rats. D Representative ICP trace with “raw” (blue line) and “smoothed” (red line) signals, the latter used to calculate the mean wave amplitude (MWA), represented in E (n = 5 of each). F Correlation analysis of MWA as a function of the ICP, n = 10, nR2 = 0.01, p = 0.80. Histological preparations of lean (G) and testosterone-treated obese (H) rat eyes for quantification of the retinal nerve fiber layer (RNFL) thickness (indicated with black bars, see inset images) quantified in I (n = 6 obese + TT and n = 3 lean Zucker rats). Statistical significance evaluated with Student’s unpaired t-test or simple linear regression and results shown as mean ± SEM, ns = not significant