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Fig. 3 | Fluids and Barriers of the CNS

Fig. 3

From: Oxygen glucose deprivation-pretreated astrocyte-derived exosomes attenuates intracerebral hemorrhage (ICH)-induced BBB disruption through miR-27a-3p /ARHGAP25/Wnt/β-catenin axis

Fig. 3

ADEVs mitigated ICH-induced BBB injury A. Schematic illustration presented that EVs from OGD-stimulated astrocytes was injected into mice from tail vein. B. Representative images showing EB extravasation 3 days after ICH induction. C. Quantitative analysis of EB extravasation. D. Representative western blot image of occludin, claudin‐5 and ZO-1 in peri-hematoma region of mice brain were measured by western blotting. E. Immunofluorescence staining for ZO-1/CD31 in the peri-hematoma region. Scale bar: 20 μm. **p < 0.01 versus indicated group; *p < 0.05 versus indicated group. All data were expressed as mean ± SEM of at least 3 independent experiments

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Fluids and Barriers of the CNS

ISSN: 2045-8118