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Fig. 1 | Fluids and Barriers of the CNS

Fig. 1

From: Oxygen glucose deprivation-pretreated astrocyte-derived exosomes attenuates intracerebral hemorrhage (ICH)-induced BBB disruption through miR-27a-3p /ARHGAP25/Wnt/β-catenin axis

Fig. 1

Astrocyte protected against hemin-induced BBB disruption through secreting exosomes A. TEER of monolayer bEnd.3 cells. B. Immunoblot images showing the expression of occludin, claudin-5 and ZO-1 in bEnd.3 cell monolayers. C. Morphological characterization of ADEVs observed under a TEM. D. The concentration and size distribution of ADEVs analyzed by NTA. E. Western blot analysis of EV surface maker proteins TSG101, CD81, CD63, and CD9. F. Fluorescence microscope was used to observe the uptake of PKH67-labeled ADEVs (green) by bEnd. 3 cells. Scale bar: 20 μm. **p < 0.01 versus indicated group; *p < 0.05 versus indicated group. All data were expressed as mean ± SEM of at least 3 independent experiments

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Fluids and Barriers of the CNS

ISSN: 2045-8118