Fig. 7
From: Large molecules from the cerebrospinal fluid enter the optic nerve but not the retina of mice
Different models of fluid transport around the optic nerve head. Conventional models (left) propose that CSF drains along the optic nerve sub-arachnoid space to lymphatics in the sclera and connective tissue surrounding the optic nerve. Retinal interstital fluid drains into the choroid via the RPE. The ocular glymphatic hypothesis (center) proposes that CSF circulates through the retina via the central retinal vessels. Based on data presented here, we propose a revised model (right), where CSF does not enter the retina but retinal fluid can drain into the optic nerve head