Fig. 6

Small CSF tracers predominantly circulate within the leptomeninges of the spinal cord and parenchyma. A, B Cross sectional histology showing small CSF tracer distribution (brown) in the spinal cord parenchyma, spine leptomeninges, and spine dura 10 min after 1.9-nm gold nanoparticle (AuNP) injection into the right lateral ventricle in P7 rodents. The anterior median fissure (AMF), ventral horn (VH), subarachnoid angle (SA), dorsal root ganglion (DRG), dorsal root (DR), pia mater (PM), subarachnoid space (SAS), dura mater (DM), root attachment zone (RAZ), and arachnoid mater (AM) are indicated. A scalebar = 1 mm, A inset scalebar = 25 µm, B scalebar = 25 µm. C High magnification histology showing 1.9-nm AuNP distribution in the dorsal root ganglion. Scalebar = 50 µm. All data are representative of 3 rodents