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Fig. 4 | Fluids and Barriers of the CNS

Fig. 4

From: Application of a new MDCKII-MDR1 cell model to measure the extent of drug distribution in vitro at equilibrium for prediction of in vivo unbound brain-to-plasma drug distribution

Fig. 4

Correlation between log-transformed in vitro determined Kp,brain and in vivo derived Kp,brain for selected reference compounds (n = 12), excluding uptake substrates (metoclopramide, doxepin, diphenhydramine, and fluoxetine). A depicts Uni-L, while B represents Bi-L. The in vitro data represents the mean ± SD of three passages conducted on three individual filters (n = 3, total N = 9), while the in vivo data represents three minipigs (n = 1, total N = 3). ‘n’ denotes test occasions, and ‘total N’ denotes the total number of replicates. C presents a comparison between the two applied in vitro methods. Low recovery compounds are shown in distinct symbols, altanserin as a square, and propranolol as a triangle

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Fluids and Barriers of the CNS

ISSN: 2045-8118