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Fig. 2 | Fluids and Barriers of the CNS

Fig. 2

From: Application of a new MDCKII-MDR1 cell model to measure the extent of drug distribution in vitro at equilibrium for prediction of in vivo unbound brain-to-plasma drug distribution

Fig. 2

Comparison of log-transformed 700 μM BSA free fractions (fu, 700 μM BSA) and Göttingen minipig 100% plasma (fu,p). The solid lines represent the line of unity and twofold difference, while the dotted line shows the line of best fit from linear regression analysis. Mean data are presented (n = 16, triplicate determinations on a single test occasion for all compounds, except for Altanserin and Way-100635, which were tested on two occasions). The data and standard deviations (SD) are shown as mean and variation between all 6 replicates)

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Fluids and Barriers of the CNS

ISSN: 2045-8118