Fig. 8
From: Protective effects of pyrroloquinoline quinone in brain folate deficiency
Effect of folate deficiency and PQQ treatment on the gene expression of the folate transporters RFC (Slc19a1) and PCFT (Slc46a1) in whole brains of wildtype mice assigned to control (2 mg/kg folate) or FD (0 mg/kg folate) diets. A RFC gene expression was significantly increased in control and FD mouse brains following the 10-day PQQ treatment (20 mg/kg/day) compared to saline vehicle. B PCFT gene expression was significantly increased in control and FD mouse brains following the 10-day PQQ treatment (20 mg/kg/day) compared to saline vehicle. Results are presented as mean relative mRNA expression compared to the saline vehicle ± SEM normalized to the housekeeping gene cyclophilin B from N = 5–6 mouse brains. One-way ANOVA with Bonferroni’s post-hoc test. Asterisks represent significant differences (*P < 0.05, **P < 0.01, ***P < 0.001)