Preventive effect of intermittent cerebrospinal fluid drainage for secondary chronic hydrocephalus after aneurysmal subarachnoid hemorrhage

Table 3 The odds ratio of the development of sNPH after SAH

	sNPH (-)	sNPH (+)	A–OR^† (95% CI)	P value	M–OR^§ (95% CI)	P value
Total number	108	96
Female	80	55	0.35 (0.20–0.60)	0.001	0.42 (0.20–0.87)	0.049
Age (60 y.o. or older)	56	64	1.86 (1.15–2.99)	0.033	1.86 (1.15–2.99)	0.076
Intermittent CSF drainage	46	22	0.39 (0.23–0.66)	0.003	0.25 (0.11–0.57)	0.005
Endovascular coiling	58	43	0.70 (0.44–1.12)	0.210	2.45 (1.12–5.35)	0.059
Aneurysm location
MCA	29	10	reference		reference
ACA	29	39	5.24 (2.44–11.24)	< 0.001	9.66 (3.4–27.4)	< 0.001
IC-PCoA	24	21	2.45 (1.11–5.42)	0.063	4.18 (1.43–12.21)	0.028
ICA	10	7	2.30 (0.81–6.53)	0.188	3.6 (0.83–15.61)	0.151
posterior circulation	16	19	4.59 (1.94–10.86)	0.004	5.26 (1.39–19.92)	0.040
WFNS scale
Grade I	46	15	reference		reference
Grade II	38	17	1.43 (0.72–2.86)	0.392	1.32 (0.56–3.11)	0.590
Grade III	7	6	2.44 (0.85–6.96)	0.162	2.18 (0.65–7.32)	0.290
Grade IV	7	23	9.22 (3.87–21.99)	< 0.001	8.46 (3.01–23.75)	< 0.001
Grade V	10	35	10.51 (4.87–22.69)	< 0.001	4.84 (1.78–13.14)	0.009
Fisher CT rating scale
Group 1 or 2	11	4	reference		reference
Group 3	89	74	2.11 (0.77–5.81)	0.224	0.65 (0.20–2.12)	0.549
Group 4	8	18	6.10 (1.82–20.44)	0.014	0.84 (0.19–3.76)	0.844
Acute hydrocephalus	11	47	9.53 (5.0–18.17)	< 0.001	5.40 (2.37–12.28)	< 0.001
Cerebral vasospasm	11	17	1.66 (0.83–3.33)	0.229	1.28 (0.47–3.48)	0.681
Cilostazol usage	35	31	1.03 (0.63–1.70)	0.915	0.54 (0.23–1.24)	0.222
Statin usage	38	31	0.91 (0.55–1.49)	0.747	0.45 (0.20–1.00)	0.099

A-OR^†; The age-adjusted odds ratio in logistic regression analysis
M-OR^§; Multivariate odds ratio for sNPH after adjustment for age, gender, CSF drainage method, treatment method, aneurysm location, WFNS scale, Fisher CT rating scale, acute hydrocephalus, cerebral vasospasm, cilostazol usage, and statin usage

ISSN: 2045-8118