Fig. 7From: Pathogenic mechanisms and therapeutic implications of extracellular matrix remodelling in cerebral vasospasmThe interaction mechanisms between ECM and VSMC. VSMCs can synthesize and secrete ECM components, as well as enzymes such as metalloproteinases, to regulate ECM; ECM can, in turn, control VSMCs through its physical properties (such as stiffness and structure) and biochemical factors (such as growth factors released after ECM degradation)Back to article page