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Fig. 3 | Fluids and Barriers of the CNS

Fig. 3

From: Pathogenic mechanisms and therapeutic implications of extracellular matrix remodelling in cerebral vasospasm

Fig. 3

Possible mechanisms of extracellular matrix–integrin–cell interactions inducing vasoconstriction. A Integrin binding to fibronectin activates nuclear factor-kappa B (NF-κB). B NF-κB activates IL-8. C IL-8 activates G protein-coupled receptors, leading to the activation of phospholipase C and downstream inositol 1,4,5-trisphosphate, leading to the release of Ca2+ from intracellular stores. D The vascular smooth muscle undergoes contraction

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Fluids and Barriers of the CNS

ISSN: 2045-8118